(Kiʻi hōʻaiʻē: Polofesa John Nicholls, Kauka Kaukaʻi o ke Keʻena ʻo Pathology, HKUMed; a me Polofesa Malik Peiris, Tam Wah-Ching Polofesa i Lapaʻau ʻEpekema a me ka Luna Hoʻokele o Virology, Kula o ka Public Health, HKUMed; a me Electron Microscope Unit, HKU. )

Ma mua o ka noʻonoʻo ʻana "inā paha mākou e hopohopo e pili ana i ka ʻano Omicron a ʻaʻole paha", e ʻike mua mākou i ka ʻano ʻano SARS-CoV-2 Omicron, i kū wale ʻia ma ʻApelika Hema i ka lā 9 Nowemapa 2021, i kāhi i ka honua ma ka hopena o ka lā aʻe. mahina a hana i nā huaʻōlelo e like me nā maʻi breakthrough, ke kolu o nā dosis a me nā mea hoʻoikaika i nā huli wela.

ʻOi aku ka paʻakikī o ka protein spike mutated no mākou e pale aku i nā maʻi maʻi.

ʻO ke kiʻi microscopic electron ma ka hoʻomaka ʻana o ka ʻatikala ka kiʻi "Omicron" mua o ka honua i hoʻokuʻu ʻia e Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKUMed) ma Dekemaba 8, 2021:

He ʻano lei aliʻi ka ʻili o ka ʻāpana virus, ʻo ia ka spike protein (S protein) i hoʻohana ʻia e ka maʻi e hoʻouka i ke kelepona.

Ke hilinaʻi nei ka maʻi i kēia mau protein spike e hoʻopaʻa i nā mea hoʻokipa ma ka ʻili o ke kelepona, e hoʻoulu ai i ka mīkini endocytosis o ka cell e wehe i ka puka i kahi ʻenemi weliweli a laila e hoʻopaʻa i nā cell e kōkua iā lākou e hana hou i nā mea maʻi virus hou i hiki iā lākou ke hoʻopili i nā cell hou.

No laila, ʻaʻole ʻo ka spike protein wale nō ke kī no ka maʻi maʻi e hoʻouka i nā cell akā ʻo ka pahuhopu hoʻi no ke kano e hoʻomaʻamaʻa i ka ʻōnaehana pale e "pololei" e ʻike a hopu i ka maʻi.ʻOi aku ka nui o ka hoʻololi ʻana, ʻoi aku ka maʻalahi o nā antibodies i hoʻokomo ʻia i ka maʻi e nalo iā lākou.

Mai ke kiʻi aʻe e hoʻohālikelike ana i nā hiʻohiʻona ʻekolu-dimensional o "Delta" a me "Omicron" spike protein i paʻi ʻia e ka hale hoʻokipa hanohano ʻo Bambino Gesu ma Roma ma Nowemapa 27, 2021, hiki iā ʻoe ke hoʻomaopopo i ke kumu i ʻoi aku ka maʻalahi o Omicron ma mua o Delta.

(Source/WHO official website)

ʻO nā kūlana i hōʻailona ʻia e ka waihoʻoluʻu, ʻo ia nā ʻāpana mutated i ʻokoʻa mai ka maʻi virus kumu.Wahi a ka loiloi, aia ma ka liʻiliʻi he 32 mau hoʻololi kī i loko o ka protein spike o "Omicron", ʻoi aku ma mua o "Delta", a ʻo nā ʻāpana ʻulaʻula loa i hoʻopaʻa ʻia i nā kūlana e launa pū me nā cell kanaka.

ʻO ia mau hoʻololi e maʻalahi i ka "Omicron" e hoʻouka i nā pūnaewele kanaka e hana hou, e laha i waena o ka poʻe a pale aku i ka pale ʻana i ka lāʻau lapaʻau i loaʻa, e alakaʻi ana i nā maʻi a i ʻole nā ​​​​maʻi hou.

Hoʻopili maʻalahi ʻo "Omicron" i ka bronchus akā ʻaʻole hiki ke komo i loko o ka māmā.

Wahi a nā hopena noiʻi i paʻi ʻia e HKUMed ma kāna pūnaewele paʻa ma ka lā 15 Dekemaba, ua hoʻopiʻi ka ʻano ʻo Omicron ma kahi o 70 mau manawa wikiwiki ma mua o Delta a me ke kumu mua o Covid-19 i loko o ka bronchus kanaka akā ʻoi aku ka maikaʻi o ka ʻiʻo o ka māmā kanaka.

(Figure Source/HKUMed official website)

Hiki i kēia ke wehewehe i ke kumu e laha koke ai ʻo "Omicron" aʻo nā hōʻailona mua o ka maʻi (ka ʻāʻī ʻāʻī, ka ihu ihu) hiki ke kuhihewa ʻia he anu maʻamau akā ʻoi aku ka haʻahaʻa o ka maʻi.

Mai noʻonoʻo ʻoe no ka mea ʻoi aku ka liʻiliʻi o ka "Omicron" i ka maʻi nui.ʻO wai ka mea ʻike i ka hopena hope e kali nei iā mākou?

ʻO ka mea hou aku, aia nā "Delta" a me "Influenza" e nānā mau ana iā mākou i ka manawa like!ʻO ke ala maikaʻi loa e pale aku ai iā lākou, ʻo ia ka hoʻāʻo e mālama i ko mākou palekana i kahi kiʻekiʻe kiʻekiʻe i kēlā me kēia lā.

No laila ʻaʻole pono mākou e hopohopo nui e pili ana iā "Omicron" akā pono mākou e makaʻala i ka mālama ʻana.

He aha ke ʻano inā loaʻa kahi kelepona i ka ʻano Omicron?

E nānā i kēia kiʻi microscopic electron i hāʻawi ʻia e HKUMed.

(Photo Credit/HKUMed & Electron Microscope Unit, HKU)

ʻO kēia ka micrograph electron o kahi cell Vero (monkey kidney) 24 mau hola ma hope o ka maʻi me ka ʻano Omicron o SARS-CoV-2.Hiki iā ʻoe ke ʻike i ka nui o nā maʻi virus e hana hou ana i loko o nā vesicles cell, a ua hoʻokuʻu ʻia nā ʻāpana virus i hana hou ʻia ma luna o ka ʻili o ke kelepona me ka mākaukau e hana i kā lākou hana.

He maʻi hou wale nō kēia i hoʻopuka hou ʻia e ka maʻi me ka hoʻohana ʻana i "hoʻokahi cell".He wikiwiki loa!ʻO ka mea pōmaikaʻi, he hoʻokolohua in vitro cell wale nō.Inā loaʻa ia i loko o vivo, ʻaʻole maopopo iā mākou ka nui o nā cell e ʻeha, a ʻo ka mea maʻi i kēia manawa he asymptomatic pinepine;ke manaʻo hewa kekahi a makemake e pale aku, ua lohi loa!

Ma hope o ka maʻi, aia kekahi mau maʻi i loko o ke kelepona aʻo kekahi ma waho o ke kelepona.E hana ka ʻōnaehana pale i nā maʻi ma nā ʻano like ʻole.

Hiki i nā antibody i ho'okomo 'ia e ka lā'au lapa'au ke hopu wale (neutralize) i ka ma'i ma waho o ke keena.Inā hiki ke hoʻopaʻa ʻia ka maʻi maʻi i ka wā e paheʻe ai i loko o ke kelepona, maʻalahi nā mea;inā hoʻopili ka maʻi i ka cell, pono nā cell immune e hūnā i ka interferon e pale i ka hoʻopiʻi viral i loko o nā pūnaewele a hoʻemi i ka nui a me ka wikiwiki o ka hoʻonui ʻana i ka maʻi viral a pono pū kekahi "killer T cell" a i ʻole "natural killer cell" e pepehi i nā maʻi maʻi.

ʻO nā maʻi ʻelua i hopu ʻia e nā antibodies a pepehi i nā cell maʻi e pono ai nā macrophages e ʻohi i nā ʻāpana.Ma mua o kēia, pono e kōkua nā macrophages a me nā cell dendritic i ka hoʻouna ʻana i nā hōʻailona i "helper T cell", nā luna kiʻekiʻe o ka ʻōnaehana pale, a laila hāʻawi i nā kauoha pololei e hana i nā cell cytotoxic T a me ka neutralizing antibodies.

Hiki i ka hoʻopaʻa ʻana ke hoʻoulu i nā antibodies, a hiki i nā lāʻau antiviral ke kāohi i ka hana hou ʻana o ka maʻi i loko o nā cell a hoʻolohi i ka laha ʻana o ka maʻi.Eia nō naʻe, no ka holoi ʻana i ka maʻi maʻi, pono ia i nā mea āpau o ka ʻōnaehana pale e hoʻoneʻe piha a hoʻoikaika ʻia.

No laila, ma hope o ka hoʻopaʻa ʻia ʻana, pehea e hoʻonui nui ai i nā cell immune, hoʻoikaika i ka pane immune, hoʻomaikaʻi i ka hana immune, hoʻoikaika i ka pale pale, a pale i ka ʻeha nui?

Mai ka noiʻi ʻana i ka makahiki 1990,ʻO Ganoderma lucidumua hōʻoia ʻia e hoʻolalelale i ka maturation o nā cell dendritic, hoʻoponopono i ka ʻokoʻa o nā cell T, hoʻoulu i ka hana ʻana o nā antibodies e nā cell B, hoʻoikaika i ka ʻokoʻa o nā monocytes-macrophages, a hoʻonui i ka hana o nā pūnae pepehi maoli, kōkua me ka hoʻonui ʻana o nā ʻano like ʻole. nā pūnaewele immune a me ka huna ʻana o nā cytokines like ʻole, a he hopena hoʻoponopono piha i ka ʻōnaehana pale.Ua hōʻuluʻulu ʻia kēia mau hopena ma ke kiʻikuhi ma lalo nei.

Ma ka hahai ʻana, e wehewehe mākou iā ʻoe i ka hohonu "no ke ahaʻO Ganoderma lucidumhiki ke kōkua iā mākou e hoʻoikaika i ka palekana e pono ai mākou e hakakā i nā maʻi maʻi "ma o kekahi mau pepa i paʻi ʻia ma nā nūpepa honua.Ma mua o kēlā, manaʻolana mākou ua hoʻomaka ʻoe e ʻaiʻO Ganoderma lucidumno ka mea, he mea nui ka pale ʻana i kēlā me kēia lā.Ma ka mālama ʻana i kahi ʻōnaehana pale maikaʻi i kēlā me kēia lā hiki iā mākou ke hōʻoia i ko mākou palekana i kēlā me kēia lā.

HOPE

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona.

★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e GanoHerb.

★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, pono e hoʻohana ʻia i loko o ke ʻano o ka mana a hōʻike i ke kumu: GanoHerb.

★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i nā kuleana pili kānāwai.

★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.

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