Izindaba zokusula kukangqongqoshe waseJapan uShinzo Abe zenza umhlaba waqaphela i-ulcerative colitis.Imbangela yalesi sifo isekuhlulekeni kokulawulwa kwamasosha omzimba, okubangela ukuhlasela okuphindaphindiwe kokuvuvukala.

I-Ganoderma lucidum, ohlale enikeza umbono wokuthi "ukuthuthukisa ukungatheleleki", empeleni uyinkosi "ekulawuleni ukuvuvukala".

I-ulcerative colitis iyodwa iyinkinga enkulu.Uma ukhetha inyama ephekiwe enezinga eliphezulu lokushisa noma inyama ebomvu ekudleni kwakho, maningi amathuba okuthi ikhuthaze ukuvuvukala kwamathumbu kanye nomdlavuza wekoloni.

Kodwa-ke, uma i-ganoderma triterpene ingasetshenziswa ukugcina amathumbu, ingakwazi ukuxazulula inkinga enkulu.Ngoba ngokocwaningo lwezilwane olwanyatheliswa nguSolwazi Daniel Sliva wase-Indiana University School of Medicine ku-“PLOS ONE” ngo-2012:

Ukuphathwa ngomlomo kwe-GLT, okukhishwe kwe-triterpene ye-Ganoderma lucidum fruiting body, kunganciphisa izinga lokuvuvukala nokulimala kwamathumbu, kunciphise ukwanda kwe-polyp kanye nezilonda zezicubu, futhi kuvimbele ukukhula komdlavuza nokukhula kwesimila lapho izici ezimbili ezingenhla eziyingozi zihlangana.

Ngaphezu kwalokho, ukuvikela kwangaphambili (ukuthatha i-300 mg/kg kathathu ngeviki) kusebenza kangcono kunokusebenzisa i-Ganoderma triterpene (ithatha i-500 mg/kg kathathu ngeviki) lapho isici esiyingozi sivela, futhi umthamo odingekayo nawo uphansi (Bheka ithebula elingezansi).

Vikela amangqamuzana amathumbu futhi ukhulule ukuvuvukala kuyisihluthulelo
 
Emthelela wesikhathi eside we-carcinogens yokudla kanye ne-ulcerative colitis, kunganiReishi amakhoweI-triterpene GLT inganikeza ukuvikeleka kwamathumbu? Ngokobufakazi obuhlaziywe kulolu cwaningo, izizathu zingahlukaniswa cishe zibe yizici ezintathu:
1. Yehlisa ubuthi be-carcinogens: lawula i-enzyme (cytochrome P450) eyenza i-heterocyclic amine PhIP emzimbeni, futhi ivimbele i-PhIP ukuthi icushwe yi-enzyme ibe into enomsebenzi we-carcinogenic.
2. Vikela amangqamuzana amathumbu: vimbela ukusebenza kwama-molecule amaprotheni ahilelekile ekuvuvukeni nasekukhuleni kwamangqamuzana emangqamuzaneni amathumbu (Umfanekiso 1) ukuze angasebenzi kalula yi-enteritis stimuli kanye ne-intestinal carcinogens.
3. Lawula impendulo yokuzivikela komzimba: ukunciphisa inani lama-macrophages angena ngaphakathi kwezicubu ze-colon (Umfanekiso 2), ukuze impendulo yokuvuvukala ingaqhubeki yanda ngenxa yokubamba iqhaza ngokweqile kwama-macrophages, ngaleyo ndlela kunciphise ukuvuvukala nokunciphisa ithuba lomdlavuza wamangqamuzana.

Umfanekiso 1: I-Ganoderma triterpenes ivimbela ukwanda kwamaseli okungavamile

Umfanekiso 2: I-Ganoderma triterpenes ivimbela impendulo yokuvuvukala kwama-macrophages

Umthamo onconyelwe umzimba womuntu

I-GLT esetshenziswe kulolu cwaningo ingxube ye-triterpene etholwe ngokukhipha imizimba ye-fruiting ye-Ganoderma lucidum ngendlela ethile.Izingxenye zayo eziyinhloko i-ganoderic acid A (3.8 mg/g), i-ganoderic acid H (1.74 mg/g) ne-ganoderic acid F (0.95 mg/g).
 
Abacwaningi baguqule umthamo osebenza kahle kakhulu esivivinyweni segundane wenza umthamo womuntu omdala onesisindo esingamakhilogremu angama-60 kuye kwangama-80.90-120 amagremu we-GLT ngeviki (isilinganiso samagremu angu-12.9 kuya ku-17.1 we-GLT ngosuku) angaba nemiphumela efanayo ekuhlolweni kwezilwane.
 
Njengoba isisindo sezilwane zokuhlola ezidla i-GLT sisakhula ngokujwayelekile, futhi abukho ubuthi obungavamile besibindi nezinso, i-blood lipid metabolism kanye ne-blood glucose metabolism.Ngakho-ke, kubantu abathanda inyama ebomvu kodwa futhi abane-ulcerative colitis, ukufaka i-Ganoderma lucidum triterpenes ukuvimbela nokwelapha umdlavuza we-colorectal kubonakala kufaneleka ukucatshangelwa.
 
Lingzhiilawula ukuzivikela komzimba futhi ifaneleka nokuvuvukala okungavamile
 
Ngenxa yezindaba zokusula kuka-Abe, ucwaningo lwangaphambilini lwe-Ganoderma lucidum lwavela, kuphela kwatholakala ukuthi i-Ganoderma lucidum polysaccharides kanye ne-triterpenes inomphumela ku-ulcerative colitis.
 
Eqinisweni, i-Ganoderma lucidum ingakwazi futhi ukukhulula Isifo sika-Crohn, olunye uhlobo lwesifo samathumbu esivuvukalayo esibangelwa ukuzivikela komzimba, nokuvuvukala kwamathumbu amancane okubangelwa ama-painkillers (bheka Izikhombo 2 kuya ku-4 ukuze uthole imininingwane).
 
Le miphumela iphinde ifakazele ukuthi i-Ganoderma lucidum inamandla okulawula ukuvuvukala nokuthuthukisa ukungatheleleki.
 
Izithako ezihlukene zeGanoderma lucidum zinemisebenzi ehlukene.Uma i-Ganoderma lucidum polysaccharides ne-Ganoderma lucidum triterpenes ingadliwa ngesikhathi esifanayo, umphumela uzoba ngcono.
 
Kodwa-ke, kungakhathaliseki ukuthi yisiphi isithako se-Ganoderma lucidum esidliwayo, noma ngabe uyidla wedwa noma uyethula emndenini wakho nakubangane, sicela uqiniseke ukuthi ukhetha imikhiqizo ye-Ganoderma lucidum yekhwalithi engaguquki, ngoba ukulawula izindinganiso zenkampani kuphela okuqinile kungaqinisekisa ukuphepha kanye nokuphepha. ukusebenza kahle kwemikhiqizo kusuka ezinhlobonhlobo kuya ekucutshungulweni.Ukulawulwa kwekhwalithi okujwayelekile kungenza imikhiqizo egcina umzimba womuntu unempilo.
 
Izithenjwa
1. USliva D, et al.I-Mushroom Ganoderma lucidum ivimbela i-colitis-associated carcinogenesis kumagundane.PLoS One.2012;7(10):e47873.
2. U-Liu C, nabanye.I-Anti-inflammatory Effects ye-Ganoderma lucidumTriterpenoid ku-Human Crohn's Disease Ehlotshaniswa Nokunciphisa Ukulawulwa kwe-NF-κB Signaling.I-Inflamm Bowel Dis.2015 Aug;21(8):1918-25.
3. U-Hanaoka R, et al.Ukukhishwa okuncibilika emanzini okusuka kusiko lwe-Ganoderma lucidum (Reishi) mycelia (Eqokwe njenge-MAK) kuthambisa i-murine colitis edalwe yi-trinitrobenzenesulphonicacid.Scan J Immunol.2011 Nov;74(5):454-62.

4. UNagai K, et al.Ama-polysaccharides atholakala ku-Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced ukulimala kwamathumbu amancane ngokufakwa kwe-GM-CSF kusuka kuma-macrophages.Iseli Immunol.2017 Okthoba;320:20-28.

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali we-“Ganoderma lucidum: Ingenious Beyond Description” (eshicilelwe ku-People's Medical Publishing House ngo-April 2017).

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