Nkhani zakusiya ntchito kwa nduna ya ku Japan Shinzo Abe zidapangitsa dziko lapansi kuzindikira matenda am'mimba.Chiyambi cha matendawa chagona pakulephera kwa chitetezo chamthupi, kumayambitsa kuukira kobwerezabwereza kwa kutupa.

Ganoderma lucidum, yomwe nthawi zonse yakhala ikupereka lingaliro la "kuwonjezera chitetezo chokwanira", kwenikweni ndi mbuye pa "kuwongolera kutupa".

Ulcerative colitis yokha ndi vuto lalikulu.Ngati mumakonda nyama yophika kwambiri kapena yofiira pazakudya zanu, imatha kulimbikitsa kutupa kwamatumbo ndi khansa yapakhungu.

Komabe, ngati ganoderma triterpene ingagwiritsidwe ntchito kusunga matumbo, ikhoza kuthetsa mavuto ambiri.Chifukwa malinga ndi kuyesa kwa nyama kofalitsidwa ndi Pulofesa Daniel Sliva wa Indiana University School of Medicine mu "PLOS ONE" mu 2012:

Kuwongolera pakamwa kwa GLT, gawo la triterpene la Ganoderma lucidum fruiting body, limatha kuchepetsa kuchuluka kwa kutupa ndi kuwonongeka kwa m'mimba, kuchepetsa kuchuluka kwa ma polyp ndi zotupa za minofu, ndikuletsa khansa ndi kukula kwa chotupa pamene zinthu ziwiri zomwe zili pamwambazi zikuphatikizana.

Komanso, chitetezo chisanachitike (kutenga 300 mg / kg katatu pa sabata) ndichothandiza kwambiri kuposa kupereka Ganoderma triterpene (kutenga 500 mg / kg katatu pa sabata) pamene chiopsezo chikuwonekera, ndipo mlingo wofunikira umakhalanso wotsika (Onani tebulo ili m'munsimu).

Kuteteza maselo am'mimba ndikuchepetsa kutupa ndiye chinsinsi
 
Pakutha kwa nthawi yayitali kwa zakudya zopatsa thanzi komanso matenda am'mimba, chifukwa chiyaniReishi bowatriterpene GLT ikhoza kuteteza matumbo? Malinga ndi umboni womwe wafufuzidwa mu phunziroli, zifukwa zikhoza kugawidwa m'magulu atatu:
1. Chepetsani poizoni wa carcinogens: sungani enzyme (cytochrome P450) yomwe imayambitsa heterocyclic amine PhIP m'thupi, ndikuletsa PhIP kuti isagwiritsidwe ntchito ndi enzyme kukhala chinthu chokhala ndi carcinogenic.
2. Tetezani ma cell a m'mimba: kuletsa kuyambitsa kwa mamolekyu a mapuloteni omwe amakhudzidwa ndi kutupa ndi kufalikira kwa maselo m'maselo a m'mimba (Chithunzi 1) kuti zisawonongeke mosavuta ndi enteritis stimuli ndi matumbo carcinogens.
3. Yang'anirani chitetezo cha mthupi: kuchepetsa chiwerengero cha macrophages omwe amalowa m'matumbo a m'matumbo (Chithunzi 2), kotero kuti kuyankha kotupa sikupitirire kuwonjezeka chifukwa cha kutenga nawo mbali mopitirira muyeso wa macrophages, motero kuchepetsa kutupa ndi kuchepetsa mwayi wa khansa ya maselo.

Chithunzi 1: Ganoderma triterpenes imalepheretsa kuchuluka kwa maselo osadziwika bwino

Chithunzi 2: Ganoderma triterpenes imalepheretsa kuyankha kwa kutupa kwa macrophages

Mlingo wovomerezeka wa thupi la munthu

GLT yogwiritsidwa ntchito mu phunziroli ndi chisakanizo cha triterpene chomwe chimapezeka pochotsa matupi a fruiting a Ganoderma lucidum m'njira yapadera.Zigawo zake zazikulu ndi ganoderic acid A (3.8 mg/g), ganoderic acid H (1.74 mg/g) ndi ganoderic acid F (0.95 mg/g).
 
Ofufuzawa adatembenuza mlingo wopambana kwambiri pakuyesera mbewa kukhala mlingo wa munthu wamkulu wolemera ma kilogalamu 60 mpaka 80.90-120 magalamu a GLT pa sabata (avareji ya 12.9 mpaka 17.1 magalamu a GLT patsiku) angakhale ndi zotsatira zofanana pakuyesera nyama.
 
Popeza kulemera kwa nyama zoyeserera zomwe zimadya GLT kukukulirakulirabe, ndipo palibe chiwopsezo chachilendo cha chiwindi ndi impso, kagayidwe ka lipid m'magazi ndi kagayidwe ka shuga m'magazi.Chifukwa chake, kwa anthu omwe amakonda nyama yofiyira komanso omwe ali ndi ulcerative colitis, kuwonjezera Ganoderma lucidum triterpenes kupewa ndi kuchiza khansa yapakhungu kumawoneka koyenera kuganiziridwa.
 
Lingzhiimayang'anira chitetezo chamthupi komanso ndi yoyenera kutupa kwachilendo
 
Chifukwa cha nkhani yosiya ntchito ya Abe, kafukufuku wam'mbuyomu wa Ganoderma lucidum adapezeka, koma adapeza kuti Ganoderma lucidum polysaccharides ndi triterpenes amakhudza ulcerative colitis.
 
Ndipotu, Ganoderma lucidum imathanso kuthetsa Matenda a Crohn, mtundu wina wa matenda opweteka a m'mimba omwe amayamba chifukwa cha autoimmunity, ndi kutupa kwamatumbo ang'onoang'ono opangidwa ndi opha ululu (onani Maumboni 2 mpaka 4 kuti mudziwe zambiri).
 
Zotsatira izi zimatsimikiziranso kuti Ganoderma lucidum imatha kuwongolera kutupa ndikuwonjezera chitetezo chokwanira.
 
Zosakaniza zosiyanasiyana za Ganoderma lucidum zimakhala ndi ntchito zosiyanasiyana.Ngati Ganoderma lucidum polysaccharides ndi Ganoderma lucidum triterpenes akhoza kudyedwa nthawi imodzi, zotsatira zake zidzakhala bwino.
 
Komabe, zilibe kanthu kuti Ganoderma lucidum imadyedwa ndi chiyani, kaya mumadya nokha kapena mumauza achibale anu ndi anzanu, chonde onetsetsani kuti mwasankha zinthu za Ganoderma lucidum zamtundu wokhazikika, chifukwa kuwongolera miyezo yokhazikika pamakampani kumatha kutsimikizira chitetezo ndi chitetezo. mphamvu ya zinthu kuchokera ku zovuta kupita ku processing.Kuwongolera kokhazikika kumatha kupanga zinthu zomwe zimapangitsa kuti thupi la munthu likhale lathanzi.
 
Maumboni
1. Sliva D, et al.Bowa Ganoderma lucidum amaletsa colitis-associated carcinogenesis mu mbewa.PLoS One.2012;7(10):e47873.
2. Liu C, ndi ena.Zotsatira Zotsutsa-kutupa za Ganoderma lucidumTriterpenoid mu Matenda a Human Crohn Ogwirizana ndi Downregulation ya NF-κB Signaling.Kutupa M'mimba Dis.2015 Aug; 21(8):1918-25.
3. Hanaoka R, et al.Zomwe zimasungunuka m'madzi kuchokera ku chikhalidwe cha Ganoderma lucidum (Reishi) mycelia (Wosankhidwa ngati MAK) amathandizira murine colitis yoyambitsidwa ndi trinitrobenzenesulphonicacid.Scand J Immunol.2011 Nov; 74 (5): 454-62.

4. Nagai K, ndi al.Polysaccharides yochokera ku Ganoderma lucidum fungus mycelia ameliorate indomethacin-imayambitsa kuvulala kwamatumbo ang'onoang'ono kudzera mu kulowetsa GM-CSF kuchokera ku macrophages.Ma cell Immunol.2017 Oct; 320:20-28.

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza za chidziwitso choyamba cha Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa "Ganoderma lucidum: Ingenious Beyond Description" (yofalitsidwa mu The People's Medical Publishing House mu April 2017).

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