Iindaba zokurhoxa komphathiswa waseJapan uShinzo Abe zenza ihlabathi laqaphela isifo sokudumba kwesilonda esiswini.Isizathu esisisiseko sesi sifo silele ekungaphumeleli kokulawulwa kwe-immune system, okubangela ukuhlaselwa ngokuphindaphindiweyo kokuvuvukala.

I-Ganoderma lucidum, ehlala inika ingcamango "yokuphucula i-immunity", ngokwenene iyinkosi "ekulawuleni ukuvuvukala".

I-ulcerative colitis iyodwa yingxaki enkulu.Ukuba ukhetha inyama ephekiweyo enobushushu obuphezulu okanye inyama ebomvu ekutyeni kwakho, kunokwenzeka ukuba ikhuthaze ukudumba kwamathumbu kunye nomhlaza webala.

Nangona kunjalo, ukuba i-ganoderma triterpene ingasetyenziselwa ukugcina amathumbu, inokukwazi ukusombulula uninzi lweengxaki.Ngenxa yokuba ngokutsho kovavanyo lwezilwanyana olupapashwe nguNjingalwazi uDaniel Sliva wase-Indiana University School of Medicine kwi-"PLOS ONE" ngo-2012:

Ulawulo lomlomo lwe-GLT, isicatshulwa se-triterpene se-Ganoderma lucidum fruiting body, inokunciphisa iqondo lokudumba kwamathumbu kunye nomonakalo, ukunciphisa ukwanda kwe-polyp kunye nezilonda zezicubu, kunye nokuthintela umhlaza kunye nokukhula kwethumba xa kukho izinto ezimbini ezinobungozi ezingasentla.

Ngaphezu koko, ukhuseleko lwangaphambili (ukuthatha i-300 mg / kg kathathu ngeveki) lusebenza ngakumbi kunokulawula i-Ganoderma triterpene (ukuthatha i-500 mg / kg kathathu ngeveki) xa umngcipheko ubonakala, kwaye idosi efunekayo nayo iphantsi ( (Jonga. itafile engezantsi).

Khusela iiseli zamathumbu kwaye ukhulule ukuvuvukala ngundoqo
 
Kwimpembelelo yexesha elide le-carcinogens yokutya kunye ne-ulcerative colitis, kutheniReishi mushroomI-triterpene GLT inokubonelela ngokhuseleko lwamathumbu? Ngokobungqina obuhlalutyiweyo kolu phononongo, izizathu zinokwahlulwa ngokurhabaxa zibe yimiba emithathu:
1. Ukunciphisa ubuthi be-carcinogens: lawula i-enzyme (i-cytochrome P450) eyenza i-metabolizes i-heterocyclic amine PhIP emzimbeni, kwaye ithintele i-PhIP ukuba isebenze yi-enzyme ibe yinto enomsebenzi we-carcinogenic.
2. Khusela iiseli zamathumbu emathunjini: thintela ukusebenza kweeprotheyini zeprotheyini ezibandakanyekayo ekudumbeni kunye nokwanda kweeseli kwiiseli zamathumbu (Umfanekiso 1) ukwenzela ukuba zingasebenzi lula yi-enteritis stimuli kunye ne-intestinal carcinogens.
3. Ukulawula impendulo ye-immune: ukunciphisa inani le-macrophages engena kwi-colon tissue (Umfanekiso 2), ukwenzela ukuba impendulo yokuvuvukala ayiyi kuqhubeka ikhula ngenxa yokuthatha inxaxheba ngokugqithiseleyo kwe-macrophages, ngaloo ndlela inciphisa ukuvuvukala kunye nokunciphisa ithuba lomhlaza weseli.

Umzobo 1: I-Ganoderma triterpenes inqanda ukwanda kweeseli ezingaqhelekanga

Umzobo 2: I-Ganoderma triterpenes inqanda impendulo yokuvuvukala kwama-macrophages

Idosi ecetyiswayo kumzimba womntu

I-GLT esetyenziswe kolu phando ngumxube we-triterpene ofunyenwe ngokukhupha imizimba ye-fruiting ye-Ganoderma lucidum ngendlela ethile.Amacandelo ayo aphambili yi-ganoderic acid A (3.8 mg / g), i-ganoderic acid H (1.74 mg / g) kunye ne-ganoderic acid F (0.95 mg / g).
 
Abaphandi baguqule idosi ephezulu esebenzayo kuvavanyo lwegundane kwidosi kumntu omdala onobunzima be-60 ukuya kwi-80 kilogram.I-90-120 grams ye-GLT ngeveki (umyinge we-12.9 ukuya kwi-17.1 grams ye-GLT ngosuku) iya kuba nemiphumo efanayo kwizilingo zezilwanyana.
 
Ekubeni ubunzima bezilwanyana zokulinga ezisebenzisa i-GLT zisakhula ngokuqhelekileyo, kwaye akukho sibindi esingaqhelekanga kunye netyhefu yezintso, i-blood lipid metabolism kunye ne-blood glucose metabolism.Ke ngoko, kubantu abathanda inyama ebomvu kodwa abane-ulcerative colitis, ukongeza i-Ganoderma lucidum triterpenes ukuthintela kunye nokunyanga umhlaza we-colorectal kubonakala kufanelekile ukuqwalaselwa.
 
Lingzhiilawula i-immunity kwaye ifanelekile ukudumba okungaqhelekanga
 
Ngenxa yeendaba zokurhoxa kuka-Abe, uphando oludlulileyo lwe-Ganoderma lucidum lwaye lwavela, lwafumanisa ukuba i-Ganoderma lucidum polysaccharides kunye ne-triterpenes zinefuthe kwi-ulcerative colitis.
 
Enyanisweni, i-Ganoderma lucidum inokunciphisa i-Crohn's Disease, olunye uhlobo lwesifo sofuba esibangelwa yi-autoimmunity, kunye nokuvuvukala kwamathumbu amancinci okubangelwa yi-painkillers (jonga iiReferensi ze-2 ukuya kwi-4 ngeenkcukacha).
 
Ezi ziphumo zingqina ukuba i-Ganoderma lucidum inamandla okulawula ukudumba kunye nokuphucula ukhuselo lomzimba.
 
Izithako ezahlukeneyo zeGanoderma lucidum zinemisebenzi eyahlukeneyo.Ukuba i-Ganoderma lucidum polysaccharides kunye ne-Ganoderma lucidum triterpenes ingadliwa ngexesha elifanayo, umphumo uya kuba ngcono.
 
Nangona kunjalo, kungakhathaliseki ukuba yeyiphi na isithako seGanoderma lucidum esidliweyo, nokuba uyitya wedwa okanye uyazisa kusapho lwakho nabahlobo, nceda uqiniseke ukuba ukhetha iimveliso zeGanoderma lucidum ezinomgangatho ongaguqukiyo, kuba kuphela ukulawulwa kwemigangatho engqongqo yeshishini kunokuqinisekisa ukhuseleko kunye nokhuseleko. ukusebenza kakuhle kweemveliso ukusuka kwiintlobo ukuya kukulungiswa.Ukulawulwa komgangatho osemgangathweni kunokwenza iimveliso ezigcina umzimba womntu usempilweni.
 
Iimbekiselo
1. Sliva D, et al.I-Mushroom Ganoderma lucidum inqanda i-colitis-associated carcinogenesis kwiimpuku.PLoS One.2012;7(10):e47873.
2. ULiu C, kunye nabanye.Iimpembelelo ezichasayo ze-Ganoderma lucidumTriterpenoid kwi-Human Crohn's Disease eNxulunyaniswe ne-Downregulation ye-NF-κB Signaling.Ukudumba kweThumbu Dis.2015 Aug;21(8):1918-25.
3. UHanaoka R, et al.Isicatshulwa esinyibilikayo samanzi esivela kwinkcubeko ye-Ganoderma lucidum (Reishi) mycelia (Echongwe njenge-MAK) iphucula i-murine colitis eyenziwa yi-trinitrobenzenesulphonicacid.Scand J Immunol.2011 Nov;74(5):454-62.

4. uNagai K, et al.I-Polysaccharides evela kwi-Ganoderma lucidum fungus mycelia ameliorate indomethacin-eyenziwe ukulimala kwamathumbu amancinci ngokufakwa kwe-GM-CSF kwi-macrophages.Iseli Immunol.2017 Okt;320:20-28.

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela kwi-1999. Ungumbhali we "Ganoderma lucidum: I-Ingenious Beyond Description" (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali, kwaye ubunini bubo be-GANOHERB ★ Le misebenzi ingentla ayinakuphinda iphinde iphinde iphinde iphinde isetyenziswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb ★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb ★ Ukwaphulwa kwengxelo engentla, iGanoHerb iya kulandela uxanduva lwayo olusemthethweni.

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