Wu Tingyao

Maphakathi no-2020, amathimba ocwaningo e-Delta University for Science & Technology kanye ne-Ain Shams University e-Egypt ahlanganyela ekushicileleni imibiko ku-“Drug Design, Development and Therapy” kanye “ne-Oxidative Medicine and Cellular Longevity” efakazela lokho.I-Ganodermalucidum(ebizwa nangokuthi i-Lingzhi noma i-Reishi mushroom) inganciphisa kakhulu ukulimala kwesibindi nezinso okubangelwa i-cisplatin ngemiphumela ephindwe kathathu ye-anti-oxidation, anti-inflammation kanye ne-anti-apoptosis.

Ukulandela “Ingxenye 1I-Ganoderma lucidumivikela isibindi ngokumelene ne-cisplatin hepatotoxicity” yesihloko esandulele, umbhali uzokwethula ukuthi yimaliniI-Ganoderma lucidumUmphumela wokuvikela izinso ungamelana ne-nephrotoxicity ebangelwa i-cisplatin kulesi sihloko ngethemba lokuthi idatha nobufakazi obusekelwe kusayensi kuzoletha ukuzethemba okwengeziwe kubangani abafuna ukwehlisa imiphumela emibi yokwelapha ngamakhemikhali.

Ingxenye 2I-Ganoderma lucidum ivikela izinso vs. Cisplatin nephrotoxicity

Njengokuhlolwa kwezilwane kokuthi “I-Ganoderma lucidumivikela isibindi ngokumelene ne-Cisplatin hepatotoxicity”, amagundane anempilo ahlukaniswe ngamaqembu angu-6 ngokuhlolwa kwezinsuku ezingu-10 "I-Ganoderma lucidumivikela izinso vs. Cisplatin nephrotoxicity”:

◆Iqembu Lokulawula (Qhubeko): iqembu elingakutholi ukwelashwa;
◆I-Ganoderma lucidumIqembu (GL): iqembu elingajovwe nge-cisplatin kodwa elidlayoI-Ganoderma lucidumnsuku zonke;
◆Cisplatin Group (CP): iqembu elijovwe nge-cisplatin kuphela kodwa elingadliI-Ganoderma lucidum;
◆Iqembu Lansuku zonke (Nsuku zonke): iqembu elijovwe nge-cisplatin futhi lidleI-Ganoderma Lucidumnsuku zonke;
◆Iqembu Lansuku zonke (EOD): iqembu elijovwe nge-cisplatin futhi lidleI-Ganoderma Lucidumzonke izinsuku;
◆ I-Intraperitoneal Group (ip): iqembu elijovwe i-cisplatin futhi elithola umjovo we-intraperitonealI-Ganoderma lucidum.

Bonke labo abathola i-cisplatin bajovwe nge-intraperitoneally nge-12 mg/kg ye-Cisplatin ngosuku lwesithathu lokuhlola ukuze kubangele ukulimala kwezinso okukhulu;labo abathole umjovo we-intraperitoneal weI-Ganoderma lucidumzajovwa kanye ngosuku lwesibili nolwesithupha lokuhlolwa.Okwamaqembu adlayoI-Ganoderma lucidum, kungakhathaliseki ukuthi bayidla nsuku zonke noma zonke izinsuku, yabalwa kusukela osukwini lokuqala lokuhlolwa.

Ngamanye amazwi, kulo mklamo wokuhlola, wonke amaqembu athola i-cisplatin kanyeI-Ganoderma lucidumbanikwaI-Ganoderma lucidumngaphambi komjovo we-cisplatin.Lokhu kuhluke kancane ekuhlolweni kwezilwane kokuthi “I-Ganoderma lucidumivikela isibindi ngokumelene ne-Cisplatin hepatotoxicity” lapho i-cisplatin yanikezwa khona ngosuku lokuqala lokuhlolwa (i-Cisplatin kanyeI-Ganoderma lucidumzisetshenziswa ndawonye kusukela ekuqaleni, noma i-cisplatin yanikezwa kuqala bese kamuvaI-Ganoderma lucidum).

II-Ganoderma lucidumimpahla esetshenziswe kulokhu kuhlolwa iyafana neI-Ganoderma lucidumimpahla esetshenziswe ocwaningweni lwezilwane "I-Ganoderma lucidumivikela isibindi ngokumelene ne-Cisplatin hepatotoxicity”.Wonke aqukethe ama-triterpenes, ama-sterol, ama-polysaccharides, ama-polyphenols nama-flavonoids.Umthamo weI-Ganoderma lucidumokunikezwayo, kungakhathaliseki ukuthi ngomlomo noma ngomjovo, ngu-500 mg/kg ngosuku.

(1) I-Ganoderma lucidum inciphisa ukulimala kwezicubu zezinso

Ngemuva kokuhlolwa kwezinsuku eziyi-10, kwadonswa igazi ukuze kutholwe okuqukethwe kwe-creatinine ne-urea nitrogen yegazi emagundaneni eqenjini ngalinye.Imiphumela yathola ukuthi i-cisplatin yandisa lezi zikhombo ezimbili kakhulu, okusho ukuthi izicubu zezinso zalimala kakhulu;umaI-Ganoderma lucidumisetshenziswa ngesikhathi esifanayo, ukwanda kwalezi zinkomba ezimbili kuzoncishiswa kakhulu, ikakhulukazi ukudlaI-Ganoderma lucidumnsuku zonke ikhiqiza umphumela wokuvikela osobala (Fig.

1).

Umdwebo 1Imiphumela ye-Cisplatin kanyeI-Ganodermalucidum ku-Kidney Injury Index

Imiphumela efanayo iphinde ibonakale ezingxenyeni ezingcolile zezicubu zezinso zamagundane eqenjini ngalinye (Fig. 2).Lapho i-cisplatin ibangela ukuminyana kwezinso, ukunwebeka kwe-renal tubule, kanye ne-necrosis, ukuchitheka, noma ukuwohloka kwe-vacuolar kwamangqamuzana e-renal tubular epithelial kumagundane (kunemicibisholo ehlukahlukene ebonisa ukulimala esithombeni sesigaba esinamabala), izicubu zezinso zamagundane eQembu Lansuku zonke ( Nsuku zonke) ithole ukulimala okuncane (awukho umcibisholo omelela ukulimala kumfanekiso wesigaba esinamabala).

Njengoba i-cisplatin inqwabelana kumaseli e-epithelial we-renal tubules ngobuningi, ukulimala kwamashubhu ezinso ngokwemvelo kuba inhloso enkulu yokubhekwa.Kungabonakala ngokucacile ngezinga elilinganiselwe lokulimala kwe-renal tubular lokhoI-Ganoderma luciduminganciphisa kakhulu ukulimala kwe-renal tubular okubangelwa i-cisplatin.Ikakhulukazi, ukudlaI-Ganoderma lucidumusuku ngalunye lukhiqiza umphumela wokuvikela obaluleke kakhulu.

U-T ubhekisela kumashubhu ezinso kuyilapho u-G ebhekisela ku-glomeruli ezibalweni zezingxenye zezicubu;umcibisholo ukhomba ukuminyana kwezinso, ukunwebeka kwe-tubular, i-necrosis, ukuchitheka, noma ukuwohloka kwe-vacuolar yamaseli e-renal tubule epithelial ngenxa yokulimala kwezicubu zezinso.

Fig.2 Imiphumela ye-Cisplatin kanyeI-Ganoderma lucidumesicutshini sezinso

(2)I-Ganoderma lucidumkuthuthukisa ikhono le-antioxidative kanye ne-anti-inflammatory yezicubu zezinso

Ukulimala kwe-cisplatin ezicutshini zezinso kuhileleke ekulimaleni kwe-oxidative nokulimala okuvuvukalayo.Kusukela kunkomba ye-oxidation (H₂O₂), i-antioxidant index (SOD), kanye ne-inflammation index (HMGB-1) elinganiswa ezicutshini zezinso zamagundane eqenjini ngalinye, kungaziwa ukuthi ukulimala kwe-oxidative nokulimala okuvuthayo okubangelwa i-cisplatin kungancishiswa ngokusetshenziswa okuhlangeneI-Ganoderma lucidum(Fig.

3).

Fig.3 Imiphumela ye-cisplatin kanyeI-Ganoderma lucidumkuma-oxidation kanye nezinkomba zokuvuvukala kwezicubu zezinso

(3)I-Ganoderma lucidumithuthukisa ikhono lokulwa ne-apoptotic lamaseli ezinso

Noma ngabe i-cisplatin idala ukufa kwamaseli ezinso ngokulimala kwe-oxidative noma ukulimala okuvuvukala, indlela yokufa yamaseli ezinso “yi-apoptosis.”

Eqinisweni, i-apoptosis iyindlela evamile yomzimba yokuqeda ukuguga noma amaseli angajwayelekile ukuze kugcinwe izinga lempilo.Ngakho-ke, izicubu nezitho ezivamile zingakwazi ukubona amangqamuzana e-apoptotic nganoma yisiphi isikhathi.Kodwa-ke, lapho inani elikhulu lamaseli lithola i-apoptosis ngenxa yezinto zangaphandle, ukusebenza okujwayelekile kwezicubu nezitho kuzothinteka.

Umdwebo 4 ubonisa isimo se-apoptosis sezicubu zezinso zegundane eqenjini ngalinye.Uma umbala obalayo uba mnyama, inani le-apoptosis likhulu.Ngokusobala, i-cisplatin ingadala inani elikhulu le-renal cell apoptosis, kodwa amaseli ezinso avikelwe yi-Ganoderma lucidum anokumelana okuhle ne-apoptosis okubangelwa i-cisplatin.Lapho inani lamangqamuzana ezinso ezifile liyancipha, izinga lokulimala kwezinso liyancishiswa, futhi ukusebenza kwezinso akuthinteki kangako.

Umfanekiso wesi-4 Imithelela ye-cisplatin neI-Ganoderma lucidumku-renal cell apoptosis

Kuphela ngokuvikela isibindi nezinso kungaba khona ithemba lokunqoba umdlavuza.

Ukwelapha ngamakhemikhali kuyindlela evamile nedingekayo yokwelapha umdlavuza, kodwa isici “esikabili” sokwelashwa ngamakhemikhali esibulala amangqamuzana omdlavuza futhi silimaza amangqamuzana avamile asibekezeleleki kuzo zonke iziguli.

Mhlawumbe isifiso esinamandla singamelana nesicanucanu, ukuhlanza, isifo sohudo, umlomo owomile, izilonda emlonyeni nokunye ukungaphatheki kahle, kodwa isibindi nezinso ezigaya izidakamizwa azikwazi ukuvikeleka ngesifiso esinamandla.

Uma singekho isibindi nezinso ezisebenza kahle, kungakhathaliseki ukuthi ukuqedwa ngokuphelele kwamangqamuzana omdlavuza, akusizi ngalutho.

Izihloko ezithi, “I-Lingzhi ingase ithuthukise i-hepatotoxicity ebangelwa izidakamizwa” futhi “i-Lingzhi ingase ithuthukise i-nephrotoxicity ebangelwa izidakamizwa”, ngokuhlolwa kwezilwane, zaphinda zaphendula izizathu zokuthi kungani iziguli ezinomdlavuza ezithola i-adjuvant chemotherapy nge-Lingzhi zinganqotshwa kalula ubuthi bemithi yokwelapha ngamakhemikhali. .

Kwethenjwa ukuthi lobu bufakazi besayensi bungakholisa iziguli eziningi ukuthi zingadlaI-Ganoderma lucidumngaphambi, ngesikhathi nangemva kokwelashwa ngamakhemikhali, futhi kufanele bakudle nsuku zonke.Uma bedla baneleI-Ganoderma lucidumnsuku zonke, ubuthi be-chemotherapy esibindini nasezinso bungaxazululwa kakhulu nguI-Ganoderma lucidumokokuqala.

[Umthombo Wedatha]

1. U-Yasmen F Mahran, et al.I-Ganoderma lucidumIvimbela I-Cisplatin-Induced Nephrotoxicity Ngokuvinjelwa Kwe-Epidermal Growth Factor Receptor Signaling kanye ne-Autophagy-Mediated Apoptosis.I-Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. UHanan M Hassan, et al.Ukucindezelwa Kokulimala Kwesibindi Okubangelwa I-Cisplatin Kumagundane Nge-Alarmin High-Mobility Group Box-1 Pathway byI-Ganoderma lucidum: Ucwaningo Lwethiyori Nokuhlola.Izidakamizwa Des Devel Ther.2020;14: 2335–2353.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi

kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi bungeka-GANOHERB ★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kokugunyazwa kwe-GanoHerb ★ Uma imisebenzi igunyaziwe ukuthi isetshenziswe, kufanele isetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ibonise umthombo: GanoHerb ★ Ukwephulwa kwesitatimende esingenhla, i-GanoHerb izoqhuba izibopho zayo ezingokomthetho ezihlobene ★ Umbhalo wokuqala wale ndatshana ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.

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