Wu Tingyao

Pakati pa2020, zvikwata zvekutsvagisa zveDelta University yeScience & Technology uye Ain Shams University kuEgypt vakabatana mukutsikisa mishumo mu "Drug Design, Development and Therapy" uye "Oxidative Medicine uye Cellular Longevity" zvichiratidza izvozvo.Ganodermalucidum(inonziwo Lingzhi kana Reishi mushroom) inogona kuderedza zvikuru kukuvara kwechiropa uye itsvo kunokonzerwa necisplatin kuburikidza nemigumisiro katatu ye-anti-oxidation, anti-inflammation uye anti-apoptosis.

Kutevera "Chikamu 1Ganoderma luciduminodzivirira chiropa vs. cisplatin hepatotoxicity” yechinyorwa chapfuura, munyori achasuma kuti inganiGanoderma lucidum's itsvo-protecting effect inogona kuramba nephrotoxicity inokonzerwa necisplatin muchinyorwa chino netarisiro yekuti data neumboo hunobva pasainzi zvinounza kusatya kushamwari dzinotsvaga kuderedza mhedzisiro yechemotherapy.

Chikamu 2Ganoderma lucidum inodzivirira itsvo vs. Cisplatin nephrotoxicity

Kufanana nekuedza kwemhuka pa "Ganoderma luciduminodzivirira chiropa vs. Cisplatin hepatotoxicity”, makonzo ane hutano akakamurwa kuita 6 mapoka ekuedza kwemazuva gumi pa”Ganoderma luciduminodzivirira itsvo vs. Cisplatin nephrotoxicity”:

◆ Control Group (Cont): boka risingawani kurapwa kupi nokupi;
◆Ganoderma lucidumBoka (GL): boka risina kubaiwa necisplatin asi rinodyaGanoderma lucidummazuva ese;
◆Cisplatin Group (CP): boka rinongobaiwa necisplatin asi risingadyi.Ganoderma lucidum;
◆ Zuva Nezuva Boka (Zuva Nezuva): boka rinobaiwa necisplatin uye rinodyaGanoderma Lucidummazuva ese;
◆ Rimwe Zuva Rimwe Zuva Boka (EOD): boka rinobaiwa ne cisplatin uye rinodyaGanoderma Lucidummamwe mazuva ose;
◆Intraperitoneal Group (ip): boka rinobaiwa cisplatin uye rinogamuchira intraperitoneal jekiseni reGanoderma lucidum.

Vose avo vakagamuchira cisplatin vakaiswa intraperitoneally ne 12 mg / kg yeCisplatin pazuva rechitatu rekuedza kuti vatange kukuvara kwakanyanya kwetsvo;avo vakagamuchira intraperitoneal jekiseni reGanoderma lucidumdzakabayiwa kamwe chete pazuva rechipiri nerechitanhatu rekuedza.Zvemapoka akadyaGanoderma lucidum, vangave vakaidya zuva rega rega kana mamwe mazuva ese, yakaverengerwa kubva pazuva rekutanga rekuyedza.

Mune mamwe mazwi, mune iyi yekuyedza dhizaini, mapoka ese anogamuchira cisplatin uyeGanoderma lucidumvakapiwaGanoderma lucidumpamberi pejekiseni re cisplatin.Izvi zvakasiyana zvishoma nekuedza mhuka pa“Ganoderma luciduminodzivirira chiropa vs. Cisplatin hepatotoxicity” umo cisplatin yakapihwa pazuva rekutanga rekuyedza (Cisplatin uyeGanoderma lucidumdzinoshandiswa pamwe chete kubva pakutanga, kana kuti cisplatin yakatanga kupiwa uye ipapoGanoderma lucidum).

TheGanoderma lucidumzvinhu zvakashandiswa mukuedza uku zvakafanana neGanoderma lucidumzvinhu zvakashandiswa mukuyedza mhuka pa“Ganoderma luciduminodzivirira chiropa vs. Cisplatin hepatotoxicity”.Iwo ese ane triterpenes, sterols, polysaccharides, polyphenols uye flavonoids.Chiyero cheGanoderma lucidumkupihwa, kungave nemuromo kana nejekiseni, i500 mg/kg pazuva.

(1) Ganoderma lucidum inoderedza kukuvara kweitsvo

Mushure mekuedza kwemazuva gumi, ropa rakadhonzwa kuti rione creatinine uye ropa urea nitrogen yemukati yemakonzo muboka rega rega.Mhedzisiro yakawana kuti cisplatin yakawedzera aya maviri indexes zvakanyanya, izvo zvinoreva kuti itsvo tishu yakakuvadzwa zvakanyanya;kanaGanoderma luciduminoshandiswa panguva imwe chete, kuwedzera kwezviratidzo zviviri izvi kuchaderedzwa zvakanyanya, kunyanya kudyaGanoderma lucidumzuva rega rega rinoburitsa mhedzisiro yekudzivirira iri pachena (Fig.

1).

Mufananidzo 1Migumisiro yeCisplatin uyeGanodermalucidum paKidney Injury Index

Mhedzisiro imwechete yakaratidzwawo muzvikamu zvakasvibiswa zvetsvo zviputi zvemakonzo muboka rimwe nerimwe (Fig. 2).Apo cisplatin inokonzera renal congestion, renal tubule dilatation, uye necrosis, kudurura, kana vacuolar degeneration ye renal tubular epithelial masero mumakonzo (kune miseve yakasiyana-siyana inoratidza kukuvara pane yakasvibiswa chikamu chimiro), itsvo tishu dzemakonzo eZuva Remazuva ose ( Zuva nezuva) akakuvara zvishoma (hapana museve unomiririra kukuvara pamufananidzo wechikamu chakasvibiswa).

Sezvo cisplatin ichiungana mumasero epithelial erenal tubules muhuwandu hukuru, kukuvara kwerenal tubules kunowanzova chinangwa chikuru chekucherechedza.Zvinogona kuoneka zvakajeka kubva quantified dhigirii renal tubular kukuvara kutiGanoderma luciduminogona kuderedza zvakanyanya renal tubular kukuvara kunokonzerwa ne cisplatin.Kunyanya, kudyaGanoderma lucidumzuva rega rega rinogadzira zvakanyanya kukosha kwekudzivirira.

T inoreva renal tubules apo G inoreva glomeruli pamifananidzo yezvikamu zvetishu;museve unonongedzera kune renal congestion, tubular dilatation, necrosis, kudurura, kana vacuolar degeneration yerenal tubule epithelial masero nekuda kwekukuvara kwetishu renal.

Fig.2 Migumisiro yeCisplatin uyeGanoderma lucidumpaitsvo tishu

(2)Ganoderma luciduminowedzera anti-oxidative uye anti-kuzvimba kugona kweitsvo tishu

Kukuvadzwa kwecisplatin kune itsvo tishu kunobatanidzwa mukukuvara kweoxidative uye kukuvara kwekuputika.Kubva pane oxidation index (H₂O₂), antioxidant index (SOD), uye kuzvimba index (HMGB-1) kuyerwa muitsvo matishu emakonzo muboka rimwe nerimwe, zvinogona kuzivikanwa kuti kukuvara kweoxidative uye kukuvara kwekuputika kunokonzerwa necisplatin kunogona kuderedzwa nekushandiswa kwakabatana.Ganoderma lucidum(Fig.

3).

Fig.3 Migumisiro ye cisplatin uyeGanoderma lucidumpane oxidation uye kuzvimba indexes yeitsvo tishu

(3)Ganoderma luciduminowedzera anti-apoptotic kugona kwemasero eitsvo

Pasinei nekuti cisplatin inokonzera itsvo sero kufa kuburikidza nekukuvara kweoxidative kana kukuvara kwekuzvimba, maitiro ekufa kwemasero eitsvo ndeye "apoptosis."

Muchokwadi, apoptosis ndiyo yakajairika nzira yemuviri yekubvisa kuchembera kana masero asina kujairika kuitira kuchengetedza hupenyu hwehupenyu.Naizvozvo, matishu akajairwa uye nhengo dzinogona kuona apoptotic masero chero nguva.Nekudaro, kana huwandu hukuru hwemasero hwapinda apoptosis nekuda kwezvinhu zvekunze, kushanda kwakajairwa kwematishu uye nhengo kuchakanganiswa.

Fig. 4 inoratidza apoptosis mamiriro emakonzo itsvo tishu muboka rega rega.Iyo yakasviba ruvara rwemavara, iyo yakakura nhamba yeapoptosis.Zviripachena, cisplatin inogona kukonzera nhamba yakakura yerenal cell apoptosis, asi masero erenal anodzivirirwa neGanoderma lucidum ane kuramba kwakanaka kune apoptosis kunokonzerwa necisplatin.Apo nhamba yemasero etsvo akafa inoderera, chiyero chekukuvara kwetsvo chinoderedzwa, uye kushanda kwetsvo hakunyanyi kukanganiswa.

Fig. 4 Migumisiro ye cisplatin uyeGanoderma lucidumpane renal cell apoptosis

Chete nekuchengetedza chiropa neitsvo panogona kuva netariro yekukunda kenza.

Chemotherapy ndiyo yakajairika uye inodiwa nzira yekurapa cancer, asi iyo "yakapetwa kaviri" hunhu hwechemotherapy inouraya maseru egomarara uye kukuvadza maseru akajairwa haitsungirike kune vese varwere.

Zvichida chido chakasimba chinogona kutsungirira kusvotwa, kurutsa, manyoka, muromo wakaoma, maronda emuromo uye zvimwe zvinoshungurudza, asi chiropa neitsvo zvinoshandisa zvinodhaka zvinodhaka hazvigoni kudzivirirwa nechido chakasimba.

Pane imwe nguva pasina chiropa neitsvo zvinoshanda zvakanaka, zvisinei kuti kubviswa kwemasero ekenza kwakadii, hazvina maturo.

Zvinyorwa zvinoti, "Lingzhi inogona kuvandudza hepatotoxicity" uye "Lingzhi inogona kuvandudza nephrotoxicity inokonzerwa nezvinodhaka", kuburikidza nekuedza kwemhuka, zvakare yakapindura zvikonzero nei varwere vekenza vanowana adjuvant chemotherapy neLingzhi vasingakundwe nyore nehupfu hwemishonga yechemotherapy. .

Zvinotarisirwa kuti humbowo hwesainzi uhwu hunogona kupwisa varwere vazhinji kuti vanogona kudyaGanoderma lucidumpamberi, panguva uye pashure chemotherapy, uye vanofanira kuidya mazuva ose.Kana vakadya zvakakwanaGanoderma lucidumzuva rega rega, kuchetura kwechemotherapy kuchiropa neitsvo kunogona kugadziriswa zvakanyanyaGanoderma lucidumpanguva yekutanga.

[Data Kwakabva]

1. Yasmen F Mahran, nevamwe.Ganoderma lucidumInodzivirira Cisplatin-Induced Nephrotoxicity kuburikidza neInhibition yeEpidermal Growth Factor Receptor Signaling uye Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, nevamwe.Kudzvinyirirwa kweCisplatin-Induced Hepatic Injury mumakonzo Kuburikidza neAlarmin High-Mobility Group Box-1 Pathway by.Ganoderma lucidum: Theoretical uye Kuedza Kudzidza.Zvinodhaka Devel Ther.2020;14:2335–2353.

END

Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo

kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB ★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb ★ Kana mabasa acho akatenderwa kushandiswa, iwo inofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb ★ Kutyorwa kwechirevo chiri pamusoro, GanoHerb ichaita mabasa ayo ane chekuita nemutemo ★ Zvinyorwa zvepakutanga zvechinyorwa ichi chakanyorwa muchiChinese naWu Tingyao uye chakashandurirwa muchiChirungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.

Pfuura paMillennia Health Culture

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