Wu Tingyao

N'etiti afọ 2020, ndị otu nyocha nke Mahadum Delta maka Sayensị & Teknụzụ na Mahadum Ain Shams dị na Egypt sonyeere na-ebipụta akụkọ na "Drug Design, Development and Therapy" na "Oxidative Medicine and Cellular Longevity" na-egosi nke ahụ.Ganodermalucidum(nke a na-akpọkwa Lingzhi ma ọ bụ ero Reishi) nwere ike belata mmerụ ahụ imeju na akụrụ nke cisplatin kpatara site na mmetụta atọ nke mgbochi oxidation, mgbochi mkpali na mgbochi apoptosis.

Na-esote “Nkebi nke 1Ganoderma lucidumna-echebe imeju vs. cisplatin hepatotoxicity" nke isiokwu gara aga, onye edemede ga-ewebata oleGanoderma lucidumMmetụta na-echebe akụrụ nwere ike iguzogide nephrotoxicity nke cisplatin kpatara n'isiokwu a na-atụ anya na data na ihe akaebe dabeere na sayensị ga-eme ka obi ike karịa ndị enyi na-achọ ibelata mmetụta nke chemotherapy.

Akụkụ 2Ganoderma lucidum na-echebe akụrụ vs. Cisplatin nephrotoxicity

Dị ka nnwale anụmanụ na "Ganoderma lucidumna-echebe imeju vs. Cisplatin hepatotoxicity”, a na-ekewa oke oke ahụike n'ime otu 6 maka nnwale ụbọchị iri na ”Ganoderma lucidumna-echebe akụrụ vs. Cisplatin nephrotoxicity":

◆ Otu njikwa (Ọnọdụ): otu na-adịghị enweta ọgwụgwọ ọ bụla;
◆Ganoderma lucidumOtu (GL): otu ndị a na-etinyeghị na cisplatin ma na-eri nriGanoderma lucidumkwa ụbọchị;
◆Cisplatin Group (CP): otu a na-agba naanị cisplatin ma anaghị eri nri.Ganoderma lucidum;
◆ Otu ụbọchị (kwa ụbọchị): otu a na-agba ya na cisplatin na-eri nri.Ganoderma Lucidumkwa ụbọchị;
◆Every Other Day Group (EOD): otu a na-agba ya na cisplatin na-eri nri.Ganoderma Lucidumụbọchị ọ bụla ọzọ;
◆Intraperitoneal Group (ip): otu a na-agbanye cisplatin ma na-anata intraperitoneal injections.Ganoderma lucidum.

Ndị niile natara cisplatin na-agbanye 12 mg / kg nke Cisplatin intraperitoneally n'ụbọchị nke atọ nke nnwale ahụ iji kpalite nnukwu mmerụ ahụ akụrụ;ndị natara intraperitoneal injections nkeGanoderma luciduma gbanyere ya otu ugboro n'ụbọchị nke abụọ na nke isii nke nnwale ahụ.Maka otu ndị na-eri nriGanoderma lucidum, ma ha riri ya kwa ụbọchị ma ọ bụ ụbọchị ọ bụla, a gbakọrọ ya site na ụbọchị mbụ nke nnwale ahụ.

N'ikwu ya n'ụzọ ọzọ, na nhazi nnwale a, otu niile na-anata cisplatin naGanoderma lucidume nyereGanoderma lucidumtupu injection cisplatin.Nke a dịtụ iche na nnwale anụmanụ na "Ganoderma lucidumna-echebe imeju vs. Cisplatin hepatotoxicity" nke e nyere cisplatin n'ụbọchị mbụ nke nnwale (Cisplatin naGanoderma luciduma na-ejikọta ọnụ site na mmalite, ma ọ bụ na-ebu ụzọ nye cisplatinGanoderma lucidum).

NkeGanoderma lucidumihe eji eme nnwale a bụ otu ihe ahụGanoderma lucidumihe eji eme nnwale anụmanụ na "Ganoderma lucidumna-echebe imeju vs. Cisplatin hepatotoxicity”.Ha niile nwere triterpenes, sterols, polysaccharides, polyphenols na flavonoids.The dose nkeGanoderma lucidumenyere, ma ọ bụ ọnụ ma ọ bụ ntụtụ, bụ 500 mg / kg kwa ụbọchị.

(1) Ganoderma lucidum na-ebelata mmerụ ahụ akụrụ

Mgbe nnwale nke ụbọchị iri gasịrị, a dọtara ọbara iji chọpụta ọdịnaya creatinine na ọbara urea nitrogen nke oke n'ime otu ọ bụla.Nsonaazụ achọpụtara na cisplatin mụbara ọnụọgụ abụọ ndị a nke ọma, nke pụtara na anụ ahụ akụrụ merụrụ ahụ nke ukwuu;ọ bụrụGanoderma luciduma na-eji n'otu oge ahụ, mmụba nke ihe ngosi abụọ a ga-ebelata nke ukwuu, karịsịa iri nriGanoderma lucidumkwa ụbọchị na-arụpụta mmetụta nchebe doro anya (Fig.

1).

Ihe osise 1Mmetụta nke Cisplatin naGanodermalucidum na Ndekọ mmerụ ahụ akụrụ

A na-egosipụtakwa otu nsonaazụ ahụ na ngalaba ntụpọ nke anụ ahụ akụrụ nke oke na otu ọ bụla (Fig 2).Mgbe cisplatin na-akpata mkpọchị akụrụ, renal tubule dilatation, na necrosis, ịwụfu, ma ọ bụ vacuolar degeneration nke renal tubular epithelial sel na oke (enwere akụ dị iche iche na-egosi mmerụ ahụ na ọnụ ọgụgụ akụkụ nke ntụpọ), akwara akụrụ nke oke nke otu ụbọchị. Kwa ụbọchị) nwere mmerụ kacha nta (ọ nweghị akụ na-anọchite anya mmerụ ahụ na ọnụ ọgụgụ ngalaba nwere ntụpọ).

Ebe ọ bụ na cisplatin na-agbakọba n'ime mkpụrụ ndụ epithelial nke tubules gbasara akụrụ n'ọtụtụ buru ibu, mmerụ ahụ nke tubules gbasara akụrụ na-aghọkarị ihe a na-ahụ anya.Enwere ike ịhụ ya nke ọma site na ọnụọgụ ọnụọgụ nke mmerụ ahụ tubularGanoderma lucidumnwere ike ibelata mmerụ ahụ gbasara tubular gbasara akụrụ nke cisplatin kpatara.Karịsịa, iri nriGanoderma lucidumkwa ụbọchị na-emepụta mmetụta nchebe kachasị mkpa.

T na-ezo aka na tubules gbasara akụrụ ebe G na-ezo aka na glomeruli na ọnụ ọgụgụ nke akụkụ anụ ahụ;Àkụ áká na-ezo aka na mkpochi nke akụrụ, tubular dilatation, necrosis, mwụfu, ma ọ bụ mmebi nke mkpụrụ ndụ epithelial gbasara akụrụ n'ihi mmerụ ahụ gbasara akụrụ.

fig.2 Mmetụta nke Cisplatin naGanoderma lucidumna akụrụ anụ ahụ

(2)Ganoderma lucidumna-akwalite ikike mgbochi oxidative na mgbochi mkpali nke anụ ahụ akụrụ

Mmebi nke cisplatin na anụ ahụ akụrụ na-etinye aka na mmerụ ahụ oxidative na mmerụ ahụ ọkụ.Site na oxidation index (H₂O₂), antioxidant index (SOD), na mbufụt index (HMGB-1) tụrụ na akụrụ anụ ahụ nke oke na nke ọ bụla otu, ọ nwere ike mara na oxidative mmerụ na mkpali mmerụ kpatara cisplatin nwere ike ibelata site na ijikọta ọnụ.Ganoderma lucidum(Fig.

3).

fig.3 Mmetụta nke cisplatin naGanoderma lucidumna oxidation na mbufụt indexes nke akụrụ anụ ahụ

(3)Ganoderma lucidumna-akwalite ikike mgbochi apoptotic nke mkpụrụ ndụ akụrụ

N'agbanyeghị ma cisplatin na-akpata ọnwụ akụrụ site na mmerụ ahụ oxidative ma ọ bụ mmerụ ahụ, ụdị ọnwụ nke mkpụrụ ndụ akụrụ bụ "apoptosis."

N'ezie, apoptosis bụ usoro nkịtị nke anụ ahụ iji kpochapụ ịka nká ma ọ bụ mkpụrụ ndụ na-adịghị mma iji nọgide na-adị mma.Ya mere, anụ ahụ na akụkụ ahụ nkịtị nwere ike ịchọpụta mkpụrụ ndụ apoptotic n'oge ọ bụla.Otú ọ dị, mgbe ọnụ ọgụgụ dị ukwuu nke mkpụrụ ndụ na-enweta apoptosis n'ihi ihe ndị dị n'èzí, a ga-emetụta ọrụ nkịtị nke anụ ahụ na akụkụ ahụ.

Fig. 4 na-egosi ọnọdụ apoptosis nke anụ ahụ akụrụ oke na otu ọ bụla.Ka ọchịchịrị na-agba agba, ka ọnụ ọgụgụ apoptosis na-abawanye.N'ụzọ doro anya, cisplatin nwere ike ime ka ọnụ ọgụgụ dị ukwuu nke renal cell apoptosis, ma mkpụrụ ndụ akụrụ nke Ganoderma lucidum na-echebe nwere ezigbo nguzogide apoptosis nke cisplatin kpatara.Mgbe ọnụọgụ mkpụrụ ndụ akụrụ nwụrụ anwụ na-ebelata, ogo nke mmerụ akụrụ na-ebelata, ọrụ akụrụ anaghịkwa emetụta ya.

Fig. 4 Mmetụta nke cisplatin naGanoderma lucidumna apoptosis renal cell

Naanị site na ichekwa imeju na akụrụ ka enwere ike inwe olile anya imeri kansa.

Chemotherapy bụ ụzọ a na-ahụkarị na nke dị mkpa iji gwọọ ọrịa kansa, mana njirimara "ọnụ abụọ" nke chemotherapy nke na-egbu mkpụrụ ndụ kansa ma na-emebi mkpụrụ ndụ nkịtị bụ ihe a na-apụghị ịnagide maka ndị ọrịa niile.

Ikekwe ọchịchọ siri ike nwere ike iguzogide ọgbụgbọ, ọgbụgbọ, afọ ọsịsa, ọnụ nkụ, ọnya ọnụ na ahụ erughị ala ndị ọzọ, mana imeju na akụrụ ndị na-eme ka ọgwụ na-emepụta ọgwụ agaghị enwe ike ichebe site na ọchịchọ siri ike.

Ozugbo imeju na akụrụ na-arụ ọrụ nke ọma, n'agbanyeghị otú mkpochapụ mkpụrụ ndụ cancer si dị, ọ baghị uru.

Isiokwu ndị a, "Lingzhi nwere ike imeziwanye hepatotoxicity nke ọgwụ na-akpata" yana "Lingzhi nwere ike melite nephrotoxicity nke ọgwụ na-akpata", site na nyocha anụmanụ, zara ọzọ ihe kpatara na ndị ọrịa cancer na-anata ọgwụgwọ kemoterapi na Lingzhi anaghị adị mfe imeri site na nsị nke ọgwụ chemotherapy. .

A na-atụ anya na ihe akaebe sayensị ndị a nwere ike ime ka ọtụtụ ndị ọrịa kwenye na ha nwere ike iri nriGanoderma lucidumtupu, n'oge na mgbe chemotherapy gasịrị, ha kwesịrị iri ya kwa ụbọchị.Ọ bụrụ na ha rie nke ọmaGanoderma lucidumkwa ụbọchị, enwere ike idozi nsi nke chemotherapy na imeju na akụrụGanoderma lucidumna nke mbụ.

[Ebe data]

1. Yasmen F Mahran, et al.Ganoderma lucidumNa-egbochi Nephrotoxicity Cisplatin na-ebute site na Mgbochi nke Epidermal Growth Factor Retator Signaling na Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, et al.Mgbochi nke mmerụ ịba ọcha n'anya Cisplatin kpatara na oke site na Alarmin High-Mobility Group Box-1 PathwayGanoderma lucidum: Ihe omumu ihe omumu na nnwale.Drug Des Devel Ther.2020;14: 2335–2353 .

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ mbụGanoderma lucidumozi

kemgbe 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede, na onye nwe ya bụ GANOHERB ★ Ọrụ ndị a dị n'elu enweghị ike ịmegharị, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke GanoHerb ★ Ọ bụrụ na e nyere ọrụ ndị ahụ ikike iji, ha ekwesịrị iji ya mee ihe n'ime oke ikike ma gosipụta isi mmalite: GanoHerb ★ Mmebi nke nkwupụta a dị n'elu, GanoHerb ga-agbaso ọrụ iwu metụtara ya ★ Wu Tingyao dere ederede mbụ nke isiokwu a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ, Nwada Wu Tingyao.

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