Wu Tingyao

Bohareng ba 2020, lihlopha tsa lipatlisiso tsa Univesithi ea Delta ea Saense le Theknoloji le Univesithi ea Ain Shams naheng ea Egepeta li ile tsa ikopanya le ho hatisa litlaleho ho "Morero oa Lithethefatsi, Nts'etsopele le Therapy" le "Oxidative Medicine le Cellular Longevity" ho paka hore.Khanodermalucidum(e boetse e bitsoa Lingzhi kapa Reishi mushroom) e ka fokotsa haholo kotsi ea sebete le liphio e bakoang ke cisplatin ka liphello tse tharo tsa anti-oxidation, anti-inflammation le anti-apoptosis.

Ho latela "Karolo ea 1Ganoderma lucidume sireletsa sebete khahlanong le cisplatin hepatotoxicity” ea sehlooho se fetileng, mongoli o tla hlahisa hore na ke bokaeGanoderma lucidum's phello ea ho sireletsa liphio e ka hanela nephrotoxicity e bakoang ke cisplatin sehloohong sena ka tšepo ea hore boitsebiso le bopaki bo thehiloeng ho saense bo tla tlisa kholiseho e eketsehileng ho metsoalle e batlang ho fokotsa litla-morao tsa chemotherapy.

Karolo ea 2Ganoderma lucidum e sireletsa liphio vs. Cisplatin nephrotoxicity

Joalo ka tlhahlobo ea liphoofolo "Ganoderma lucidume sireletsa sebete khahlanong le Cisplatin hepatotoxicity ", likhoto tse phetseng hantle li arotsoe ka lihlopha tsa 6 bakeng sa teko ea matsatsi a 10 "Ganoderma lucidume sireletsa liphio khahlano le Cisplatin nephrotoxicity”:

◆ Sehlopha sa Taolo (Tsoelang Pele): sehlopha se sa fumaneng phekolo leha e le efe;
◆Ganoderma lucidumSehlopha (GL): sehlopha se sa keneng ka cisplatin empa se jaGanoderma lucidumletsatsi le letsatsi;
◆Cisplatin Group (CP): sehlopha se kentsoeng feela ka cisplatin empa se sa jeGanoderma lucidum;
◆ Sehlopha sa Letsatsi le Letsatsi (Letsatsi le leng le le leng): sehlopha se entoa ka cisplatin le ho jaMofuta oa "Ganoderma Lucidum".letsatsi le letsatsi;
◆ Sehlopha se seng le se seng sa Letsatsi (EOD): sehlopha se kenngoa ka cisplatin 'me se jaMofuta oa "Ganoderma Lucidum".letsatsi le leng le le leng;
◆Intraperitoneal Group (ip): sehlopha se kentsoeng cisplatin 'me se fumana ente ea intraperitoneal eaGanoderma lucidum.

Bohle ba amohetseng cisplatin ba ile ba kenngoa ka intraperitoneally ka 12 mg / kg ea Cisplatin letsatsing la boraro la teko ea ho baka kotsi e matla ea liphio;ba fumaneng ente ea intraperitoneal eaGanoderma lucidumli ile tsa entoa hang ka letsatsi la bobeli le la botšelela la teko.Bakeng sa lihlopha tse jangKhanoderma lucidum, ebang ba ne ba e ja letsatsi le leng le le leng kapa letsatsi le leng le le leng, e ne e baloa ho tloha letsatsing la pele la teko.

Ka mantsoe a mang, moralong ona oa liteko, lihlopha tsohle li amohela cisplatin leGanoderma lucidumba fuwaGanoderma lucidumpele ho ente ea cisplatin.Sena se fapane hanyane le teko ea liphoofolo ka "Ganoderma lucidume sireletsa sebete khahlanong le Cisplatin hepatotoxicity” eo cisplatin e ileng ea fanoa ka eona letsatsing la pele la teko (Cisplatin leGanoderma lucidumli sebelisoa hammoho ho tloha qalong, kapa cisplatin e ile ea fanoa pele ebe hamoraoGanoderma lucidum).

TheGanoderma lucidumthepa e sebelisoang tekong ena e tšoana le eaGanoderma lucidumthepa e sebelisitsoeng tekong ea liphoofolo ka “Ganoderma lucidume sireletsa sebete khahlanong le Cisplatin hepatotoxicity”.Kaofela li na le triterpenes, sterols, polysaccharides, polyphenols le flavonoids.Tekanyo eaGanoderma lucidumho fanoa, ebang ke ka molomo kapa ka ente, ke 500 mg/kg ka letsatsi.

(1) Ganoderma lucidum e fokotsa kotsi ea lisele tsa liphio

Kamora teko ea matsatsi a 10, mali a ile a huloa ho bona creatinine le mali urea nitrogen content ea likhoto sehlopheng ka seng.Liphello li fumane hore cisplatin e ekelitse li-index tsena tse peli haholo, e leng se bolelang hore lisele tsa liphio li ne li lemetse haholo;haebaGanoderma lucidume sebelisoa ka nako e le 'ngoe, ho eketseha ha matšoao ana a mabeli ho tla fokotseha haholo, haholo-holo ho jaGanoderma lucidumletsatsi le leng le le leng le hlahisa ts'ireletso e hlakileng haholoanyane (Feie.

1).

Setšoantšo sa 1Liphello tsa Cisplatin leKhanodermalucidum ho Index ea Kotsi ea Liphio

Liphello tse tšoanang li ne li boetse li bonahala likarolong tse silafetseng tsa lisele tsa liphio tsa likhoto sehlopheng ka seng (setšoantšo sa 2).Ha cisplatin e baka tšubuhlellano ea renal, renal tubule dilatation, le necrosis, tšolloe, kapa degeneration ea vacuolar ea lisele tsa renal tubular epithelial ka likhoto (ho na le metsu e fapaneng e bonts'ang kotsi setšoantšong sa karolo e silafalitsoeng), lisele tsa liphio tsa likhoto tsa Sehlopha sa Letsatsi le Letsatsi ( Letsatsi le letsatsi) o ile a tsoa kotsi e nyane haholo (ha ho na motsu o emelang likotsi setšoantšong sa karolo e nang le litšila).

Kaha cisplatin e bokellana ka bongata liseleng tsa epithelial tsa renal tubules, kotsi ea li-tubules tsa renal ka tlhaho e fetoha sepheo sa mantlha sa ho shebella.E ka bonoa ka ho hlaka ho tloha tekanyong e lekantsoeng ea kotsi ea renal tubular horeGanoderma lucidume ka fokotsa haholo kotsi ea renal tubular e bakoang ke cisplatin.Ka ho khetheha, ho jaGanoderma lucidumletsatsi le leng le le leng le hlahisa phello ea bohlokoa ka ho fetisisa ea tšireletso.

T e bua ka li-tubules tsa renal ha G e bua ka glomeruli ka lipalo tsa likarolo tsa lisele;motsu o supa tšubuhlellano ea renal, ho atoloha ha li-tubular, necrosis, ho tsoa, ​​kapa ho senyeha ha vacuolar ea lisele tsa renal tubule epithelial ka lebaka la kotsi ea lisele tsa renal.

feie.2 Liphello tsa Cisplatin leGanoderma lucidumka lisele tsa liphio

(2)Ganoderma lucidume ntlafatsa matla a anti-oxidative le anti-inflammatory a lisele tsa liphio

Tšenyo ea cisplatin ho lisele tsa liphio e ameha ho lemalang ha oxidative le kotsi ea ho ruruha.Ho tsoa ho index ea oxidation (H₂O₂), antioxidant index (SOD), le index ea ho ruruha (HMGB-1) e lekantsoeng ka har'a lisele tsa liphio tsa likhoto sehlopheng ka seng, ho ka tsejoa hore kotsi ea oxidative le kotsi ea ho ruruha e bakoang ke cisplatin e ka fokotsoa ke tšebeliso e kopanetsoeng.Ganoderma lucidum(Feie.

3).

feie.3 Liphello tsa cisplatin leGanoderma lucidumka li-index tsa oxidation le ho ruruha ha lisele tsa liphio

(3)Ganoderma lucidume ntlafatsa matla a anti-apoptotic a lisele tsa liphio

Ho sa tsotelehe hore na cisplatin e baka lefu la lisele tsa liphio ka lebaka la kotsi ea oxidative kapa kotsi ea ho ruruha, mokhoa oa lefu oa lisele tsa liphio ke "apoptosis."

Ha e le hantle, apoptosis ke mokhoa o tloaelehileng oa 'mele oa ho felisa botsofali kapa lisele tse sa tloaelehang e le ho boloka boleng ba bophelo.Ka hona, lisele tse tloaelehileng le litho tsa 'mele li ka lemoha lisele tsa apoptotic ka nako leha e le efe.Leha ho le joalo, ha palo e kholo ea lisele e kena apoptosis ka lebaka la mabaka a ka ntle, ts'ebetso e tloaelehileng ea lisele le litho tsa 'mele e tla ameha.

Setšoantšo sa 4 se bontša boemo ba apoptosis ba lithane tsa liphio tsa rat sehlopheng ka seng.Ha 'mala o silafatsang o le lefifi, ho na le palo e kholo ea apoptosis.Ho hlakile hore cisplatin e ka baka palo e kholo ea renal cell apoptosis, empa lisele tsa renal tse sirelelitsoeng ke Ganoderma lucidum li na le khanyetso e ntle ho apoptosis e bakoang ke cisplatin.Ha palo ea lisele tse shoeleng tsa liphio e fokotseha, tekanyo ea kotsi ea liphio e fokotseha, 'me mosebetsi oa liphio ha o amehe hakaalo.

Setšoantšo sa 4 Liphello tsa cisplatin leGanoderma lucidumka apoptosis ea lisele tsa renal

Ke feela ka ho sireletsa sebete le liphio ho ka bang le tšepo ea ho hlōla kankere.

Chemotherapy ke mokhoa o atileng haholo le o hlokahalang oa ho alafa mofetše, empa tšobotsi ea “maqeba a mabeli” ea chemotherapy e bolaeang lisele tsa mofetše le ho senya lisele tse tloaelehileng ha e mamellehe ho bakuli bohle.

Mohlomong takatso e matla e ka mamella ho nyekeloa ke pelo, ho hlatsa, letšollo, molomo o omeletseng, liso tsa molomo le lintho tse ling tse sa thabiseng, empa sebete le liphio tse senyang lithethefatsi li ke ke tsa sireletsoa ke takatso e matla.

Hang ha ho se na sebete le liphio tse sebetsang hantle, ho sa tsotellehe hore na ho felisoa ha lisele tsa mofetše ka botlalo hakae, ha ho na thuso.

Lingoliloeng, "Lingzhi e ka ntlafatsa lefu la sebete le bakoang ke lithethefatsi" le "Lingzhi e ka ntlafatsa nephrotoxicity e bakoang ke lithethefatsi", ka liteko tsa liphoofolo, e ile ea boela ea araba mabaka a hore na ke hobane'ng ha bakuli ba mofetše ba fumanang kalafo ea adjuvant chemotherapy le Lingzhi ba sa hlōloe habonolo ke chefo ea lithethefatsi tsa chemotherapy. .

Ho na le tšepo ea hore bopaki bona ba saense bo ka kholisa bakuli ba bangata hore ba ka jaGanoderma lucidumpele, nakong le ka mor'a phekolo ea lik'hemik'hale, 'me ba lokela ho e ja letsatsi le leng le le leng.Haeba li ja tse lekanengGanoderma lucidumletsatsi le leng le le leng, chefo ea chemotherapy ho sebete le liphio e ka rarolloa haholo keGanoderma lucidumkgetlo la pele.

[Mohloli oa Lintlha]

1. Yasmen F Mahran, le ba bang.Ganoderma lucidumE thibela Cisplatin-Induced Nephrotoxicity ka Thibelo ea Epidermal Growth Factor Receptor Signaling le Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, le ba bang.Khatello ea Kotsi ea Hepatic e Bakiloeng ke Cisplatin ho Likhoto Ka Alarmin High-Mobility Group Box-1 Pathway byGanoderma lucidum: Thuto ea Khopolo le ea Teko.Meriana e Hlahisa Ther.2020;14: 2335–2353 .

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao o ntse a tlaleha ka letsoho la peleGanoderma lucidumtlhahisoleseding

ho tloha ka 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli, 'me thepa ke ea GANOHERB ★ Mesebetsi e ka holimo e ke ke ea hlahisoa, ea qotsoa kapa ea sebelisoa ka litsela tse ling ntle le tumello ea GanoHerb ★ Haeba mesebetsi e lumelletsoe ho sebelisoa, e lokela ho sebelisoa ka har'a sebaka sa tumello le ho bontša mohloli: GanoHerb ★ Tlōlo ea polelo e ka holimo, GanoHerb e tla phehella boikarabelo ba eona ba molao bo amanang le eona ★ Mongolo oa pele oa sehlooho sena o ngotsoe ka Sechaena ke Wu Tingyao 'me oa fetoleloa ka Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.

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