Wu Tingyao

Embindini we-2020, amaqela ophando eDyunivesithi yaseDelta yeSayensi kunye neTekhnoloji kunye neYunivesithi yase-Ain Shams e-Egypt ajoyine ukupapasha iingxelo "kuYilo lweDrug, uPhuhliso kunye noNyango" kunye "ne-Oxidative Medicine kunye ne-Cellular Longevity" ebonisa ukubaI-Ganodermalucidum(ebizwa ngokuba yi-Lingzhi okanye i-mushroom ye-Reishi) inokunciphisa kakhulu isibindi kunye nokulimala kwezintso okubangelwa yi-cisplatin ngokusebenzisa imiphumo emithathu ye-anti-oxidation, i-anti-inflammation kunye ne-anti-apoptosis.

Ukulandela “iCandelo loku-1I-Ganoderma lucidumikhusela isibindi vs. cisplatin hepatotoxicity” yenqaku elidlulileyo, umbhali uya kwazisa ukuba yimaliniI-Ganoderma lucidumIsiphumo sokukhusela izintso sinokuxhathisa i-nephrotoxicity ebangelwa yi-cisplatin kweli nqaku ngethemba lokuba idatha kunye nobungqina obusekwe kwisayensi buza kuzisa ukuzithemba ngakumbi kubahlobo abafuna ukunciphisa iziphumo ebezingalindelekanga zechemotherapy.

Icandelo lesi-2I-Ganoderma lucidum ikhusela intso vs. Cisplatin nephrotoxicity

Njengovavanyo lwezilwanyana kwi "I-Ganoderma lucidumikhusela isibindi vs. Cisplatin hepatotoxicity”, iimpuku ezisempilweni zahlulwe zibe ngamaqela ama-6 kuvavanyo lweentsuku ezili-10 “I-Ganoderma lucidumikhusela izintso vs. Cisplatin nephrotoxicity”:

◆ IQela loLawulo (Qhuba): iqela elingafumani naluphi na unyango;
◆I-Ganoderma lucidumIqela (GL): iqela elingatofwanga nge-cisplatin kodwa lityaI-Ganoderma lucidumyonke imihla;
◆ Iqela leCisplatin (CP): iqela elitofwe kuphela nge-cisplatin kodwa alityiI-Ganoderma lucidum;
◆Iqela lemihla ngemihla (Mihla): iqela elitofwa nge-cisplatin kwaye lityaGanoderma Lucidumyonke imihla;
◆ Yonke enye i-Day Group (EOD): iqela elitofwe nge-cisplatin kwaye lidleGanoderma Lucidumnaliphi na usuku;
◆ Iqela le-Intraperitoneal (ip): iqela elitofelwe i-cisplatin kwaye lifumana inaliti ye-intraperitonealI-Ganoderma lucidum.

Bonke abo bafumana i-cisplatin bajojowe nge-intraperitoneally nge-12 mg / kg ye-Cisplatin ngosuku lwesithathu lovavanyo lokuqalisa ukulimala kwezintso;abo bafumana inaliti ye-intraperitoneal yeI-Ganoderma lucidumzatofwa kanye ngosuku lwesibini nolwesithandathu lovavanyo.Kuba amaqela adlayoI-Ganoderma lucidum, nokuba bayidla yonke imihla okanye yonke enye imini, yabalwa ukususela kumhla wokuqala wovavanyo.

Ngamanye amazwi, kolu yilo lovavanyo, onke amaqela afumana i-cisplatin kunyeI-Ganoderma lucidumbanikwaI-Ganoderma lucidumNgaphambi kokuba kufakwe inaliti ye-cisplatin.Oku kwahluke kancinane kulingo lwezilwanyana “I-Ganoderma lucidumikhusela isibindi vs. Cisplatin hepatotoxicity” apho i-cisplatin yanikezelwa ngosuku lokuqala lovavanyo (iCisplatin kunyeI-Ganoderma lucidumzisetyenziswa kunye ukususela ekuqaleni, okanye i-cisplatin yanikwa kuqala kwaye emva kokoI-Ganoderma lucidum).

II-Ganoderma lucidumimathiriyeli esetyenziswe kolu vavanyo iyafana neI-Ganoderma lucidumizinto ezisetyenziswe kuvavanyo lwezilwanyana "I-Ganoderma lucidumikhusela isibindi ngokuchasene neCisplatin hepatotoxicity”.Zonke ziqulethe i-triterpenes, i-sterols, i-polysaccharides, i-polyphenols kunye ne-flavonoids.Umthamo weI-Ganoderma lucidumenikwayo, nokuba ngomlomo okanye ngesitofu, yi-500 mg/kg ngosuku.

(1) I-Ganoderma lucidum iyanciphisa ukulimala kwezintso

Emva kovavanyo lweentsuku ezili-10, igazi latsalwa ukubona i-creatinine kunye ne-blood urea nitrogen umxholo weempuku kwiqela ngalinye.Iziphumo zafumanisa ukuba i-cisplatin yandisa ezi zikhombisi zimbini ngokukhawuleza, oku kuthetha ukuba izicubu zezintso zalimala kakhulu;ukubaI-Ganoderma lucidumisetyenziswe ngexesha elifanayo, ukwanda kwezi zikhombisi zibini kuya kuncitshiswa kakhulu, ngakumbi ukutyaI-Ganoderma lucidumyonke imihla ivelisa umphumo ocacileyo wokukhusela (Fig.

1).

Umzobo 1Iziphumo zeCisplatin kunyeI-Ganodermalucidum kwi-Kidney Injury Index

Iziphumo ezifanayo nazo zibonakaliswe kumacandelo ahlambulukileyo ezicubu zezintso zamagundane kwiqela ngalinye (umzobo 2).Xa i-cisplatin ibangela ukuxinana kweentso, i-renal tubule dilatation, kunye ne-necrosis, i-shedding, okanye i-vacuolar degeneration yeeseli ze-renal tubular epithelial kwiigundane (kukho iintolo ezahlukahlukeneyo ezibonisa ukulimala kumfanekiso wecandelo elinebala), izicubu zezintso zeegundane zeQela lemihla ngemihla ( Mihla yonke) ufumene umonzakalo omncinci (akukho utolo olumele ukwenzakala kumfanekiso wecandelo elinebala).

Ekubeni i-cisplatin iqokelela kwiiseli ze-epithelial ze-renal tubules ngobuninzi obukhulu, ukwenzakala kwee-renal tubules ngokwemvelo kuba yinjongo ephambili yokujonga.Inokubonwa ngokucacileyo kwiqondo elilinganisiweyo lokulimala kwe-renal tubular leyoI-Ganoderma luciduminokunciphisa kakhulu ukulimala kwe-renal tubular okubangelwa yi-cisplatin.Ngokukodwa, ukutyaI-Ganoderma lucidumyonke imihla ivelisa eyona mpembelelo ibalulekileyo yokukhusela.

I-T ibhekisela kwii-tubules ze-renal ngelixa i-G ibhekisela kwi-glomeruli kumanani amacandelo e-tissue;utolo lubonisa ukuxinana kweentso, ukunwenwa kwe-tubular, i-necrosis, ukuchithwa, okanye ukuhla kwe-vacuolar yeeseli ze-renal tubule epithelial ngenxa yokulimala kwezicubu zezintso.

ikhiwane.2 Iziphumo zeCisplatin kunyeI-Ganoderma lucidumkwizicubu zezintso

(2)I-Ganoderma lucidumiphucula amandla okulwa ne-oxidative kunye nokuchasana nokudumba kwezintso

Umonakalo we-cisplatin kwizicubu zezintso ubandakanyeka kwingozi ye-oxidative kunye nokulimala okuvuthayo.Ukusuka kwisalathiso se-oxidation (H₂O₂), i-antioxidant index (SOD), kunye ne-inflammation index (HMGB-1) ilinganiswe kwizicubu zezintso zeegundane kwiqela ngalinye, kuyaziwa ukuba ukulimala kwe-oxidative kunye nokulimala okubangelwa yi-cisplatin kunokunciphisa ukusetyenziswa okuhlangeneyo.I-Ganoderma lucidum(Ikhiwane.

3).

ikhiwane.3 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidumkwi-oxidation kunye ne-inflammation indexes ye-kidney tissue

(3)I-Ganoderma lucidumkuphucula amandla e-anti-apoptotic kwiiseli zezintso

Nokuba i-cisplatin ibangela ukufa kweeseli zezintso ngomonzakalo we-oxidative okanye ukwenzakala, indlela yokufa yeeseli zezintso "yi-apoptosis."

Ngapha koko, i-apoptosis yindlela eqhelekileyo yomzimba yokuphelisa ukwaluphala okanye iiseli ezingaqhelekanga ukuze kugcinwe umgangatho wobomi.Ke ngoko, izicubu eziqhelekileyo kunye nezitho ziyakwazi ukubona iiseli ze-apoptotic nangaliphi na ixesha.Nangona kunjalo, xa inani elikhulu leeseli lifumana i-apoptosis ngenxa yezinto zangaphandle, ukusebenza okuqhelekileyo kwezicubu kunye namalungu kuya kuchaphazeleka.

Umzobo we-4 ubonisa isimo se-apoptosis yezicubu zezintso zegundane kwiqela ngalinye.Okukhona kumnyama umbala, kokukhona likhulu inani le-apoptosis.Ngokucacileyo, i-cisplatin inokubangela inani elikhulu le-renal cell apoptosis, kodwa iiseli zezintso ezikhuselwe yi-Ganoderma lucidum zinokuxhathisa okulungileyo kwi-apoptosis ebangelwa yi-cisplatin.Xa inani leeseli zezintso ezifileyo liyancipha, iqondo lokulimala kwezintso liyancitshiswa, kwaye umsebenzi wezintso awuchaphazeleki kancinci.

Umzobo we-4 Iziphumo ze-cisplatin kunyeI-Ganoderma lucidumkwi-renal cell apoptosis

Kuphela kukukhusela isibindi kunye nezintso apho kunokubakho ithemba lokoyisa umhlaza.

I-Chemotherapy yeyona ndlela ixhaphakileyo neyimfuneko yokunyanga umhlaza, kodwa uphawu “lokubini” lwechemotherapy olubulala iiseli zomhlaza kwaye lonakalise iiseli eziqhelekileyo alunyamezeleki kuzo zonke izigulana.

Mhlawumbi umyolelo owomeleleyo unokumelana nesicaphucaphu, ukuhlanza, urhudo, umlomo owomileyo, izilonda ezisemlonyeni nezinye izinto ezingathandekiyo, kodwa isibindi nezintso ezisebenzisa iziyobisi azinakukhuselwa ngokuthanda okunamandla.

Emva kokuba kungabikho sibindi kunye nezintso ezisebenza kakuhle, kungakhathaliseki ukuba ukupheliswa ngokupheleleyo kweeseli zomhlaza, akuncedi.

Amanqaku athi, "i-Lingzhi inokuphucula i-hepatotoxicity eyenziwe ngamachiza" kwaye "i-Lingzhi inokuphucula i-nephrotoxicity eyenziwe ngamachiza", ngovavanyo lwezilwanyana, yaphinda yaphendula izizathu zokuba kutheni izigulana ezinomhlaza ezifumana i-adjuvant chemotherapy kunye ne-Lingzhi zingoyiswa lula yityhefu yamachiza echemotherapy. .

Kuthenjwa ukuba obu bungqina benzululwazi bunokuqinisekisa izigulane ezininzi ukuba zinokutyaI-Ganoderma lucidumngaphambi, ngexesha nasemva kwechemotherapy, kwaye kufuneka bayitye yonke imihla.Ukuba batya ngokwaneleyoI-Ganoderma lucidumyonke imihla, ubutyhefu bechemotherapy kwisibindi kunye nezintso zinokusonjululwa ikakhuluI-Ganoderma lucidumokokuqala.

[Umthombo weDatha]

1. UYasmen F Mahran, et al.I-Ganoderma lucidumIkhusela i-Cisplatin-Induced Nephrotoxicity ngokusebenzisa i-Inhibition ye-Epidermal Growth Factor Receptor Signaling kunye ne-Autophagy-Mediated Apoptosis.Oxid Med Iseli Longev.2020. doi: 10.1155/2020/4932587.

2. UHanan M Hassan, et al.Ukucinezelwa kweCisplatin-Induced Hepatic Injury in Rats Ngokusebenzisa i-Alarmin High-Mobility Group Box-1 Pathway byI-Ganoderma lucidum: Uphononongo lwethiyori kunye novavanyo.Drug Des Devel Ther.2020;14: 2335–2353.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi

ukusukela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali, kwaye ubunini bubo be-GANOHERB ★ Le misebenzi ingentla ayinakuphinda iphinde iphinde iphinde iphinde isetyenziswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb ★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb ★ Ukwaphulwa kwengxelo engentla, iGanoHerb iya kulandela uxanduva lwayo olusemthethweni oluhambelanayo ★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.

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