Wu Tingyao

Bartamihii-2020, kooxaha cilmi-baarista ee Jaamacadda Delta ee Sayniska & Teknolojiyada iyo Jaamacadda Ain Shams ee Masar ayaa ku biiray daabacaadda warbixinnada "Naqshadeynta Daroogada, Horumarinta iyo Daaweynta" iyo "Daawaynta Oxidative iyo Muddada Dheeraanta Cellular" oo caddaynaya taasGanodermalucidum(sidoo kale loo yaqaan Lingzhi ama likaha Reishi) waxay si weyn u yarayn kartaa dhaawaca beerka iyo kelyaha ee ay keento cisplatin iyada oo loo marayo saamaynta saddex-geesoodka ah ee anti-oxidation, anti-inflammation iyo anti-apoptosis.

Lasoco “Qaybta 1aadGanoderma lucidumwuxuu ilaaliyaa beerka vs. cisplatin hepatotoxicity" ee maqaalkii hore, qoraagu wuxuu soo bandhigi doonaa intaGanoderma lucidumSaamaynta kelyaha-ilaalinta waxay u adkeysan kartaa nephrotoxicity ee ay keento cisplatin maqaalkan iyada oo rajaynaysa in xogta iyo caddaynta ku salaysan sayniska ay keeni doonto kalsooni dheeraad ah saaxiibada doonaya inay yareeyaan dhibaatooyinka soo raaca ee daaweynta kemotherabi.

Qaybta 2Ganoderma lucidum waxay ilaalisaa kelyaha vs. Cisplatin nephrotoxicity

Sida tijaabada xayawaanka ee "Ganoderma lucidumwuxuu ilaaliyaa beerka vs. Cisplatin hepatotoxicity", jiirka caafimaadka qaba ayaa loo qaybiyaa 6 kooxood oo tijaabo ah 10-maalmoodGanoderma lucidumwaxay ilaalisaa kelyaha vs. Cisplatin nephrotoxicity":

Kooxda Xakamaynta (Cont): kooxda aan helin wax daaweyn ah;
◆Ganoderma lucidumKooxda (GL): kooxda aan lagu duro cisplatin laakiin wax cunaGanoderma lucidummaalin walba;
Kooxda Cisplatin (CP): kooxda kaliya ee lagu duro cisplatin laakiin aan cuninGanoderma lucidum;
◆Kooxda maalin walba (Maalin walba): kooxda lagu duro cisplatin oo wax cuna.Ganoderma Lucidummaalin walba;
Kooxda Maalin Kasta Oo Kale (EOD): kooxda lagu duro cisplatin oo wax cuna.Ganoderma Lucidummaalin kasta oo kale;
◆Kooxda intraperitoneal (ip): kooxda lagu duro cisplatin oo la siiyo duritaanka intraperitonealGanoderma lucidum.

Dhammaan kuwa helay cisplatin waxaa lagu duray intraperitoneal 12 mg / kg Cisplatin maalintii saddexaad ee tijaabada si loo kiciyo dhaawac kelyo ah oo daran;kuwa helay duritaanka intraperitoneal eeGanoderma lucidumayaa lagu duray hal mar maalintii labaad iyo lixaad ee tijaabada.Kooxihii cunayGanoderma lucidum, haddii ay cuneen maalin kasta ama maalin kasta, waxaa laga xisaabiyay maalintii ugu horreysay ee tijaabada.

Si kale haddii loo dhigo, qaabkan tijaabada ah, dhammaan kooxaha helaya cisplatin iyoGanoderma lucidumla siiyayGanoderma lucidumka hor duritaanka cisplatin.Tani way ka yara duwan tahay tijaabada xayawaankaGanoderma lucidumwaxa ay ilaalisaa beerka vs.Ganoderma lucidumWaa la wada isticmaalay bilowgii, ama cisplatin ayaa la siiyay marka hore ka dibnaGanoderma lucidum).

TheGanoderma lucidumwalxaha loo isticmaalo tijaabadan waxay la mid yihiin kuwaGanoderma lucidumwalxaha loo isticmaalo tijaabada xayawaanka "Ganoderma lucidumwuxuu ilaaliyaa beerka vs. Cisplatin hepatotoxicity”.Dhammaantood waxay ka kooban yihiin triterpenes, sterols, polysaccharides, polyphenols iyo flavonoids.QiyaastaGanoderma lucidumlagu siiyo, hadday afka tahay ama haddii lagu duro, waa 500 mg/kg maalintii.

(1) Ganoderma lucidum waxay yaraynaysaa dhaawaca unugyada kelyaha

Tijaabadii 10-maalmood ka dib, dhiig ayaa la soo saaray si loo ogaado creatinine iyo urea nitrogen content ee ku jira koox kasta.Natiijooyinku waxay ogaadeen in cisplatin ay si aad ah u kordhisay labadan tilmaame, taas oo macnaheedu yahay in unugyada kelyaha ay si xun u dhaawacmeen;haddiiGanoderma lucidumIsla mar ahaantaana la isticmaalo, kororka labadan tilmaame aad ayuu u yarayn doonaa, gaar ahaan cunistaGanoderma lucidummaalin kasta waxay soo saartaa saamayn difaac oo cad (Sawirka.

1).

Sawirka 1Saamaynta Cisplatin iyoGanodermalucidum on Tusmada Dhaawaca Kelyaha

Natiijooyinka isku midka ah ayaa sidoo kale ka muuqday qaybaha wasakhaysan ee unugyada kelyaha ee jiirka ee koox kasta (Jaantus. 2).Marka cisplatin uu keeno ciriiriga kelyaha, faafinta tuubada kelyaha, iyo necrosis, daadinta, ama burburka vacuolar ee unugyada epithelial tubular ee kelyaha ee jiirka (waxaa jira fallaadho kala duwan oo tilmaamaya dhaawaca shaxanka qaybta wasakhaysan), unugyada kelyaha ee jiirka Kooxda Maalinlaha ah ( Maalin walba) waxa soo gaadhay dhaawaca ugu yar (ma jirto falaar ka turjumaysa dhaawacyo shaxanka qaybta wasakhaysan).

Maadaama cisplatin ay ku ururto unugyada epithelial ee tuubooyinka kelyaha tiro badan, dhaawaca tuubooyinka kelyaha ayaa si dabiici ah u noqda bartilmaameedka ugu weyn.Waxaa si cad looga arki karaa heerka la qiyaasey ee dhaawaca tubbada kelyaha eeGanoderma lucidumwaxay si weyn u yarayn kartaa dhaawaca tubbada kelyaha ee uu keeno cisplatin.Gaar ahaan, cunistaGanoderma lucidummaalin kasta waxay soo saartaa saamaynta ugu muhiimsan ee ilaalinta.

T waxa loola jeedaa tuubooyinka kelyaha halka G uu tilmaamayo glomeruli ee tirooyinka qaybaha unugyada;Falaadhtu waxay tilmaamaysaa ciriiriga kelyaha, fiditaanka tuubada, necrosis, daadinta, ama xumaanshaha vacuolar ee unugyada epithelial kelyaha sababtoo ah dhaawaca unugyada kelyaha.

Sawirka.2 Saamaynta Cisplatin iyoGanoderma lucidumon unugyada kelyaha

(2)Ganoderma lucidumwaxay kordhisaa awoodda anti-oxidative iyo anti-bararka unugyada kelyaha

Dhaawaca cisplatin ee unugyada kelyaha ayaa ku lug leh dhaawaca oksaydhiyaha iyo dhaawaca bararka.Laga soo bilaabo index oxidation (H₂O₂), index antioxidant (SOD), iyo index bararka (HMGB-1) oo lagu qiyaaso unugyada kelyaha ee jiirka ee koox kasta, waxaa la ogaan karaa in dhaawaca oksaydhka iyo dhaawaca bararka ee uu keeno cisplatin uu yarayn karo isticmaalka wadajirka ah.Ganoderma lucidum(Sawirka.

3).

Sawirka.3 Saamaynta cisplatin iyoGanoderma lucidumon oxidation iyo index bararka unugyada kelyaha

(3)Ganoderma lucidumwaxay xoojisaa awoodda ka hortagga apoptotic ee unugyada kelyaha

Iyadoo aan loo eegin in cisplatin uu keeno dhimashada unugyada kelyaha iyada oo loo marayo dhaawac oksaydh ah ama dhaawac barar ah, qaabka dhimashada unugyada kelyaha waa "apoptosis."

Dhab ahaantii, apoptosis waa habka caadiga ah ee jirka si uu u baabi'iyo gabowga ama unugyada aan caadiga ahayn si loo ilaaliyo tayada nolosha.Sidaa darteed, unugyada caadiga ah iyo xubnaha ayaa ogaan kara unugyada apoptotic wakhti kasta.Si kastaba ha noqotee, marka tiro badan oo unugyo ah ay ku dhacaan apoptosis sababo dibadda ah, hawlgalka caadiga ah ee unugyada iyo xubnaha ayaa saameyn doona.

Jaantuska 4 ayaa muujinaya heerka apoptosis ee unugyada kelyaha jiirka ee koox kasta.Mar kasta oo midabka midabkiisu sii madoobaado, ayaa tirada apoptosis weynaysaa.Sida iska cad, cisplatin waxa uu keeni karaa tiro badan oo ah apoptosis unugyada kelyaha, laakiin unugyada kelyaha ee ay ilaaliso Ganoderma lucidum ayaa iska caabin fiican u leh apoptosis uu keeno cisplatin.Marka tirada unugyada kelyaha ee dhintay ay yaraadaan, heerka dhaawaca kelyuhu wuu yaraadaa, shaqada kelyuhuna way yaraataa.

Jaantuska 4 Saamaynta cisplatin iyoGanoderma lucidumunugyada kelyaha ee apoptosis

Kaliya ilaalinta beerka iyo kelyaha ayaa la heli karaa rajo ah in laga adkaado kansarka.

Chemotherapy waa habka ugu badan ee lagama maarmaanka u ah in lagu daweeyo kansarka, laakiin sifada "laba af leh" ee daaweynta kemotherabi ee dila unugyada kansarka iyo dhaawaca unugyada caadiga ah waa mid aan loo dulqaadan karin dhammaan bukaannada.

Waxaa laga yaabaa in niyadda xoogga leh ay u adkeysan karto lallabbo, matag, shuban, af qalalan, boogaha afka iyo raaxo la'aanta kale, laakiin beerka iyo kelyaha ee dheef-shiid kiimikaadka daawooyinka laguma ilaalin karo rabitaan xooggan.

Mar haddii aysan jirin beerka iyo kelyaha oo si fiican u shaqeeya, si kasta oo loo dabar gooyo unugyada kansarka, waa wax aan faa'iido lahayn.

Maqaallada, "Lingzhi waxaa laga yaabaa inuu hagaajiyo hepatotoxicity-daroogadu keento" iyo "Lingzhi waxaa laga yaabaa inuu hagaajiyo nephrotoxicity-daawoyinka", iyada oo loo marayo tijaabooyinka xayawaanka, mar kale ayaa ka jawaabay sababaha bukaannada kansarka ee qaata kimoterabiga adjuvant ee Lingzhi aan si fudud looga adkaan sunta daawooyinka kemotherabi .

Waxaa la rajeynayaa in cadeymahan cilmiyeed ay ku qancin karaan bukaanno badan inay cuni karaanGanoderma lucidumka hor, inta lagu jiro iyo ka dib daaweynta kemotherabi, waana inay cunaan maalin kasta.Haddii ay cunto ku filan cunaanGanoderma lucidummaalin kasta, sunta kemotherabi ee beerka iyo kelyaha ayaa inta badan lagu xalin karaaGanoderma lucidummarkii ugu horeysay.

[Isha Xogta]

1. Yasmen F Mahran, iyo al.Ganoderma lucidumWaxay ka hortagtaa nephrotoxicity-ku-abuuray Cisplatin iyada oo la joojinayo calaamadaynta soo-dhowaynta ee Cunsurka Kobaca Epidermal iyo Apoptosis- Dhexdhexaadin autophagy.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, iyo al.Xakamaynta dhaawaca Cagaarshow-Cisplatin-ku keeno Jiirka iyada oo loo marayo Alarmin High-Mobility Group Box-1 PathwayGanoderma lucidum: Daraasad aragti iyo tijaabo ah.Drug Des Devel Ther.2020;14: 2335-2353.

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao

Wu Tingyao ayaa si toos ah uga warbixinayayGanoderma lucidumxog

tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).

★ Maqaalkan waxa lagu daabacay ogolaansho gaar ah oo uu leeyahay qoraaga, lahaanshahana waxaa iska leh GANOHERB ★ Shaqooyinka kor ku xusan lama soo saari karo, lama saari karo, lamana isticmaali karo siyaabo kale iyada oo aan fasax laga helin GanoHerb ★ Haddii shaqooyinka loo oggolaaday in la isticmaalo, waa in loo istcimaalaa inta ay le'egtahay oggolaanshaha oo tilmaama isha: GanoHerb ★ Ku xad-gudbida bayaanka sare, GanoHerb waxay sii wadi doontaa mas'uuliyadeeda sharci ee la xidhiidha ★ Qoraalka asalka ah ee maqaalkan waxaa ku qoray Shiinaha Wu Tingyao waxaana u tarjumay Ingiriisi Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.

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