Wu Tingyao

Chapakati pa 2020, magulu ofufuza a Delta University for Science & Technology ndi Ain Shams University ku Egypt adalumikizana ndikusindikiza malipoti mu "Drug Design, Development and Therapy" ndi "Oxidative Medicine ndi Cellular Longevity" kutsimikizira kuti.Ganodermalucidum(wotchedwanso Lingzhi kapena Reishi bowa) amatha kuchepetsa kwambiri kuvulala kwa chiwindi ndi impso chifukwa cha cisplatin kupyolera mu zotsatira zitatu za anti-oxidation, anti-inflammation ndi anti-apoptosis.

Kutsatira "Gawo 1Ganoderma lucidumimateteza chiwindi motsutsana ndi cisplatin hepatotoxicity” ya nkhani yapitayi, wolembayo afotokoza kuchuluka kwaGanoderma lucidumKuteteza impso kungathe kukana nephrotoxicity yomwe imayambitsidwa ndi cisplatin m'nkhaniyi ndikuyembekeza kuti deta ndi umboni wozikidwa pa sayansi zibweretsa chidaliro chochuluka kwa abwenzi omwe akufuna kuchepetsa zotsatira za mankhwala amphamvu.

Gawo 2Ganoderma lucidum amateteza impso vs. Cisplatin nephrotoxicity

Monga kuyesa kwa nyama pa "Ganoderma lucidumamateteza chiwindi motsutsana ndi Cisplatin hepatotoxicity ", makoswe athanzi amagawidwa m'magulu a 6 kuti ayese masiku a 10 "Ganoderma lucidumimateteza impso motsutsana ndi Cisplatin nephrotoxicity”:

◆ Gulu Lolamulira (Cont): gulu lomwe sililandira chithandizo chilichonse;
◆Ganoderma lucidumGulu (GL): gulu lomwe silinabayidwe ndi cisplatin koma limadyaGanoderma lucidumtsiku lililonse;
◆Cisplatin Group (CP): gulu lomwe limangobayidwa ndi cisplatin koma osadyaGanoderma lucidum;
◆ Gulu latsiku ndi tsiku (Tsiku ndi tsiku): gulu lomwe limabayidwa ndi cisplatin ndikudyaGanoderma Lucidumtsiku lililonse;
◆ Gulu la Tsiku Lililonse (EOD): gulu lomwe limabayidwa ndi cisplatin ndikudyaGanoderma Lucidumtsiku lina lililonse;
◆Intraperitoneal Group (ip): gulu lomwe limabayidwa jekeseni ya cisplatin ndipo limalandira jekeseni wa intraperitonealGanoderma lucidum.

Onse omwe analandira cisplatin anabayidwa intraperitoneally ndi 12 mg / kg ya Cisplatin pa tsiku lachitatu la kuyesa kuyambitsa kuvulala kwakukulu kwa impso;omwe adalandira jakisoni wa intraperitoneal waGanoderma lucidumanabayidwa kamodzi pa tsiku lachiwiri ndi lachisanu ndi chimodzi la kuyesa.Kwa magulu omwe adadyaGanoderma lucidum, kaya adadya tsiku lililonse kapena tsiku lililonse, adawerengedwa kuyambira tsiku loyamba la kuyesa.

Mwanjira ina, pamapangidwe oyesera awa, magulu onse amalandira cisplatin ndiGanoderma lucidumanapatsidwaGanoderma lucidumpamaso pa jekeseni wa cisplatin.Izi ndizosiyana pang'ono ndi kuyesa kwa nyama pa "Ganoderma lucidumimateteza chiwindi motsutsana ndi Cisplatin hepatotoxicity” momwe cisplatin idaperekedwa tsiku loyamba la kuyesa (Cisplatin ndiGanoderma lucidumamagwiritsidwa ntchito pamodzi kuyambira pachiyambi, kapena cisplatin anapatsidwa poyamba ndiyenoGanoderma lucidum).

TheGanoderma lucidumzinthu zomwe zimagwiritsidwa ntchito poyesera izi ndizofanana ndiGanoderma lucidumzinthu zomwe zimagwiritsidwa ntchito poyesera nyama pa "Ganoderma lucidumamateteza chiwindi motsutsana ndi Cisplatin hepatotoxicity”.Zonse zili ndi triterpenes, sterols, polysaccharides, polyphenols ndi flavonoids.Mlingo waGanoderma lucidumkuperekedwa, kaya ndi pakamwa kapena jekeseni, ndi 500 mg/kg patsiku.

(1) Ganoderma lucidum imachepetsa kuvulala kwa impso

Pambuyo pa kuyesa kwa masiku 10, magazi adatengedwa kuti azindikire creatinine ndi magazi a urea nayitrogeni wa makoswe pagulu lililonse.Zotsatirazo zinapeza kuti cisplatin inachulukitsa zizindikiro ziwirizi kwambiri, zomwe zikutanthauza kuti minofu ya impso inavulala kwambiri;ngatiGanoderma lucidumamagwiritsidwa ntchito nthawi yomweyo, kuwonjezeka kwa zizindikiro ziwirizi kudzachepetsedwa kwambiri, makamaka kudyaGanoderma lucidumtsiku lililonse limapanga zodzitchinjiriza zowonekera (mkuyu.

1).

Chithunzi 1Zotsatira za Cisplatin ndiGanodermalucidum pa Impso Injury Index

Zotsatira zomwezo zinawonetsedwanso m'zigawo zowonongeka za impso za makoswe mu gulu lirilonse (mkuyu 2).Pamene cisplatin imayambitsa kusokonezeka kwaimpso, kufalikira kwa aimpso, ndi necrosis, kukhetsa, kapena kuwonongeka kwa vacuolar kwa maselo amtundu wa aimpso a epithelial mu makoswe (pali mivi yosiyanasiyana yomwe ikuwonetsa kuvulala pagawo lopindika), minofu ya impso ya makoswe a Gulu Latsiku ndi Tsiku ( Tsiku ndi tsiku) adavulala pang'ono (palibe muvi woyimira kuvulala pagawo lopindika).

Popeza cisplatin imadziunjikira m'maselo a epithelial a aimpso tubules mochuluka, kuvulala kwa machubu aimpso mwachilengedwe kumakhala cholinga chachikulu chowonera.Zitha kuwoneka bwino kuchokera ku quantified degree ya aimpso tubular kuvulala komweGanoderma lucidumimatha kuchepetsa kwambiri kuwonongeka kwa aimpso chifukwa cha cisplatin.Makamaka, kudyaGanoderma lucidumtsiku lililonse limapanga chitetezo chofunikira kwambiri.

T amatanthauza machubu aimpso pamene G amatanthauza glomeruli pazithunzi za zigawo za minofu;Muviwu umaloza kutsekeka kwa aimpso, kufalikira kwa tubular, necrosis, kukhetsa, kapena kuwonongeka kwa vacuolar kwa ma cell a aimpso a epithelial chifukwa cha kuvulala kwaimpso.

chith.2 Zotsatira za Cisplatin ndiGanoderma lucidumpa minofu ya impso

(2)Ganoderma lucidumkumawonjezera odana ndi okosijeni ndi odana ndi yotupa mphamvu ya impso minofu

Kuwonongeka kwa cisplatin ku minofu ya impso kumakhudzidwa ndi kuvulala kwa okosijeni komanso kuvulala kotupa.Kuchokera ku index ya oxidation (H₂O₂), antioxidant index (SOD), ndi index yotupa (HMGB-1) yoyesedwa mu mitsempha ya impso ya makoswe mu gulu lirilonse, zikhoza kudziwika kuti kuvulala kwa okosijeni ndi kuvulala kotupa komwe kumachitika chifukwa cha cisplatin kungachepetsedwe pogwiritsa ntchito pamodziGanoderma lucidum(Chith.

3).

chith.3 Zotsatira za cisplatin ndiGanoderma lucidumpa makutidwe ndi okosijeni ndi kutupa indexes wa impso minofu

(3)Ganoderma lucidumkumawonjezera anti-apoptotic mphamvu ya impso maselo

Mosasamala kanthu kuti cisplatin imayambitsa kufa kwa maselo a impso chifukwa cha kuvulala kwa okosijeni kapena kuvulala kotupa, njira yakufa ya maselo a impso ndi "apoptosis."

M'malo mwake, apoptosis ndi njira yabwinobwino yochotsera ukalamba kapena maselo achilendo kuti akhalebe ndi moyo.Choncho, minofu yachibadwa ndi ziwalo zimatha kuzindikira maselo a apoptotic nthawi iliyonse.Komabe, ma cell ambiri akakumana ndi apoptosis chifukwa cha zinthu zakunja, ntchito yabwinobwino ya minofu ndi ziwalo zimakhudzidwa.

Chithunzi cha 4 chikuwonetsa mawonekedwe a apoptosis a minofu ya impso za makoswe pagulu lililonse.Mtundu wodetsa umakhala wakuda, kuchuluka kwa apoptosis kumakhala kokulirapo.Mwachiwonekere, cisplatin imatha kuyambitsa kuchuluka kwa aimpso cell apoptosis, koma ma cell a aimpso otetezedwa ndi Ganoderma lucidum amakana bwino apoptosis chifukwa cha cisplatin.Pamene chiwerengero cha maselo akufa a impso achepa, mlingo wa kuvulala kwa impso umachepa, ndipo ntchito ya impso sizimakhudzidwa.

Chithunzi cha 4 Zotsatira za cisplatin ndiGanoderma lucidumpa aimpso cell apoptosis

Pokhapokha poteteza chiwindi ndi impso m'pamene pangakhale chiyembekezo chogonjetsa khansa.

Chemotherapy ndiyo njira yodziwika bwino komanso yofunikira pochiza khansa, koma "m'mbali ziwiri" za mankhwala amphamvu omwe amapha maselo a khansa ndikuwononga maselo abwinobwino ndizovuta kwa odwala onse.

Mwinamwake chifuniro champhamvu chingathe kupirira nseru, kusanza, kutsekula m'mimba, m'kamwa mouma, zilonda zam'kamwa ndi zovuta zina, koma chiwindi ndi impso zomwe zimagwiritsira ntchito mankhwala osokoneza bongo sizingatetezedwe ndi chifuniro champhamvu.

Kamodzi palibe chiwindi ndi impso zomwe zimagwira ntchito bwino, ziribe kanthu momwe maselo a khansa athetsedwera bwino, ndizopanda pake.

Nkhanizo, "Lingzhi atha kuchiritsa hepatotoxicity yopangidwa ndi mankhwala" komanso "Lingzhi atha kusintha nephrotoxicity yopangidwa ndi mankhwala", kudzera muzoyeserera zanyama, idayankhanso zifukwa zomwe odwala khansa omwe amalandila chithandizo chamankhwala adjuvant chemotherapy ndi Lingzhi sagonjetsedwa mosavuta ndi kawopsedwe ka mankhwala a chemotherapy. .

Tikukhulupirira kuti umboni wa sayansi umenewu ukhoza kutsimikizira odwala ambiri kuti akhoza kudyaGanoderma lucidumasanayambe, panthawi komanso pambuyo pa mankhwala a chemotherapy, ndipo ayenera kudya tsiku lililonse.Ngati adya mokwaniraGanoderma lucidumtsiku lililonse, kawopsedwe wa mankhwala amphamvu kwa chiwindi ndi impso akhoza makamaka kuthetsedwaGanoderma lucidumnthawi yoyamba.

[Magwero a Data]

1. Yasmen F Mahran, et al.Ganoderma lucidumImateteza Nephrotoxicity Yopangidwa ndi Cisplatin Kupyolera mu Kuletsa Epidermal Growth Factor Receptor Signaling ndi Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, ndi al.Kuponderezedwa kwa Cisplatin-Induced Hepatic Kuvulala mu Makoswe Kupyolera mu Alarmin High-Mobility Group Box-1 Pathway ndiGanoderma lucidum: Maphunziro a Theoretical and Experimental.Mankhwala Devel Ther.2020;14: 2335–2353 .

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri

kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB ★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb ★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, iwo ziyenera kugwiritsidwa ntchito mkati mwa chilolezo ndikuwonetsa gwero: GanoHerb ★ Kuphwanya mawu omwe ali pamwambawa, GanoHerb idzakwaniritsa udindo wake wokhudzana ndi malamulo ★ Zolemba zoyambirira za nkhaniyi zinalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa ku Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.

Pitani pa Millennia Health Culture

Thandizani ku Ubwino kwa Onse