Wu Tingyao

Nyob rau hauv nruab nrab-2020, pab pawg tshawb fawb ntawm Delta University rau Science & Technology thiab Ain Shams University hauv Egypt tau koom nrog kev tshaj tawm cov ntaub ntawv hauv "Kev Tsim Tshuaj, Kev Txhim Kho thiab Kev Kho Mob" thiab "Oxidative Medicine thiab Cellular Longevity" ua pov thawj tiasGanodermalucidum(tseem hu ua Lingzhi lossis Reishi nceb) tuaj yeem txo lub siab thiab lub raum raug mob los ntawm cisplatin los ntawm triple los ntawm kev tiv thaiv oxidation, tiv thaiv kab mob thiab tiv thaiv apoptosis.

Ua raws li "Part 1Ganoderma lucidumtiv thaiv daim siab vs. cisplatin hepatotoxicity” ntawm tsab xov xwm dhau los, tus sau yuav qhia ntau npaum li casGanoderma lucidumCov nyhuv tiv thaiv lub raum tuaj yeem tiv thaiv nephrotoxicity tshwm sim los ntawm cisplatin hauv tsab xov xwm no hauv kev cia siab tias cov ntaub ntawv thiab cov pov thawj raws li kev tshawb fawb yuav ua rau muaj kev ntseeg siab ntau dua rau cov phooj ywg uas nrhiav kev txo cov kev mob tshwm sim ntawm kev siv tshuaj khomob.

Ntu 2Ganoderma lucidum tiv thaiv lub raum vs. Cisplatin nephrotoxicity

Zoo li kev sim tsiaj ntawm "Ganoderma lucidumtiv thaiv daim siab vs. Cisplatin hepatotoxicity", cov nas noj qab haus huv tau muab faib ua 6 pawg rau 10-hnub sim ntawm "Ganoderma lucidumtiv thaiv lub raum vs. Cisplatin nephrotoxicity ":

◆Control Group (Cont): pab pawg uas tsis tau txais kev kho mob;
◆Ganoderma lucidumPab pawg (GL): cov pab pawg uas tsis tau txhaj tshuaj cisplatin tab sis nojGanoderma lucidumtxhua hnub;
◆ Cisplatin Group (CP): pab pawg uas tsuas yog txhaj tshuaj cisplatin tab sis tsis nojGanoderma lucidum;
◆ Pab Pawg Txhua Hnub (Txhua Hnub): pab pawg uas tau txhaj tshuaj cisplatin thiab nojGanoderma Lucidumtxhua hnub;
◆ Pab Pawg Txhua Hnub (EOD): pab pawg uas tau txhaj tshuaj cisplatin thiab nojGanoderma Lucidumtxhua hnub;
◆ Intraperitoneal Group (ip): pab pawg uas txhaj tshuaj cisplatin thiab tau txais kev txhaj tshuaj intraperitonealGanoderma lucidum.

Txhua tus neeg uas tau txais cisplatin tau txhaj tshuaj intraperitoneally nrog 12 mg / kg ntawm Cisplatin nyob rau hnub thib peb ntawm kev sim ua rau mob raum raug mob;cov neeg uas tau txais kev txhaj tshuaj intraperitonealGanoderma lucidumtau txhaj ib zaug rau hnub thib ob thiab thib rau ntawm qhov kev sim.Rau cov pab pawg uas tau nojGanoderma lucidum, txawm tias lawv noj nws txhua hnub lossis txhua hnub, nws tau suav txij thawj hnub ntawm kev sim.

Hauv lwm lo lus, hauv qhov kev sim tsim no, txhua pawg tau txais cisplatin thiabGanoderma lucidumtau muabGanoderma lucidumua ntej txhaj tshuaj cisplatin.Qhov no txawv me ntsis ntawm kev sim tsiaj ntawm "Ganoderma lucidumtiv thaiv daim siab vs. Cisplatin hepatotoxicity” nyob rau hauv uas cisplatin tau muab rau thawj hnub ntawm kev sim (Cisplatin thiabGanoderma lucidumtau siv ua ke txij thaum pib, lossis cisplatin tau muab ua ntej thiab tom qab ntawdGanoderma lucidum).

CovGanoderma lucidumcov khoom siv hauv qhov kev sim no yog tib yam li covGanoderma lucidumcov khoom siv hauv kev sim tsiaj rau "Ganoderma lucidumtiv thaiv daim siab vs. Cisplatin hepatotoxicity ".Lawv txhua tus muaj triterpenes, sterols, polysaccharides, polyphenols thiab flavonoids.Qhov koob tshuaj ntawmGanoderma lucidummuab, txawm hais tias qhov ncauj los yog txhaj tshuaj, yog 500 mg / kg ib hnub.

(1) Ganoderma lucidum txo cov mob raum

Tom qab kev sim 10-hnub, ntshav tau kos los kuaj xyuas cov creatinine thiab ntshav urea nitrogen cov ntsiab lus ntawm cov nas hauv txhua pab pawg.Cov txiaj ntsig tau pom tias cisplatin nce ob qhov ntsuas no nrawm, uas txhais tau hais tias lub raum cov ntaub so ntswg raug mob hnyav;yogGanoderma lucidumyog siv tib lub sijhawm, qhov nce ntawm ob qhov ntsuas no yuav raug txo kom tsawg, tshwj xeeb tshaj yog nojGanoderma lucidumtxhua hnub ua rau muaj kev tiv thaiv pom tseeb dua (Fig.

1).

Fig. 1Cov teebmeem ntawm Cisplatin thiabGanodermalucidum ntawm raum Injury Index

Cov txiaj ntsig zoo ib yam kuj tau tshwm sim nyob rau hauv cov stained seem ntawm lub raum cov ntaub so ntswg ntawm cov nas hauv txhua pab pawg (Fig. 2).Thaum cisplatin ua rau lub raum congestion, lub raum tubule dilatation, thiab necrosis, shedding, los yog vacuolar degeneration ntawm lub raum tubular epithelial hlwb nyob rau hauv nas (muaj ntau yam xub qhia txog kev raug mob nyob rau hauv stained seem daim duab), lub raum cov ntaub so ntswg ntawm cov nas ntawm txhua hnub pab pawg neeg ( Txhua hnub) raug mob tsawg kawg nkaus (tsis muaj xub sawv cev rau kev raug mob ntawm daim duab stained).

Txij li thaum cisplatin accumulates nyob rau hauv lub epithelial hlwb ntawm lub raum tubules nyob rau hauv ntau qhov ntau, qhov kev raug mob ntawm lub raum tubules ib txwm dhau los ua lub hom phiaj tseem ceeb ntawm kev soj ntsuam.Nws tuaj yeem pom tseeb los ntawm qhov ntsuas qhov ntsuas ntawm lub raum tubular raug mob uasGanoderma lucidumtuaj yeem txo qhov mob raum tubular raug mob los ntawm cisplatin.Tshwj xeeb, nojGanoderma lucidumtxhua hnub ua rau muaj kev tiv thaiv tseem ceeb tshaj plaws.

T yog hais txog lub raum tubules thaum G hais txog glomeruli ntawm cov duab ntawm cov ntaub so ntswg;Lub xub taw qhia rau lub raum congestion, tubular dilatation, necrosis, shedding, los yog vacuolar degeneration ntawm lub raum tubule epithelial hlwb vim lub raum cov ntaub so ntswg raug mob.

Fig.2 Cov teebmeem ntawm Cisplatin thiabGanoderma lucidumntawm lub cev nqaij daim tawv

(2)Ganoderma lucidumtxhim khu kev tiv thaiv oxidative thiab anti-inflammatory muaj peev xwm ntawm lub raum cov ntaub so ntswg

Kev puas tsuaj ntawm cisplatin rau lub raum cov ntaub so ntswg yog koom nrog oxidative raug mob thiab inflammatory kev raug mob.Los ntawm oxidation index (H₂O₂), antioxidant index (SOD), thiab inflammatory Performance index (HMGB-1) ntsuas nyob rau hauv lub raum cov ntaub so ntswg ntawm nas nyob rau hauv txhua pab pawg neeg, nws yuav paub hais tias cov oxidative raug mob thiab inflammatory kev raug mob los ntawm cisplatin yuav txo tau los ntawm kev siv ua ke ntawmGanoderma lucidum(Fig.

3).

Fig.3 Cov teebmeem ntawm cisplatin thiabGanoderma lucidumntawm oxidation thiab o indexes ntawm lub raum cov ntaub so ntswg

(3)Ganoderma lucidumtxhim kho lub peev xwm tiv thaiv apoptotic ntawm lub raum hlwb

Txawm hais tias cisplatin ua rau lub raum tuag los ntawm kev raug mob oxidative los yog kev raug mob, kev tuag ntawm lub raum hlwb yog "apoptosis."

Qhov tseeb, apoptosis yog lub cev ib txwm ua haujlwm los tshem tawm cov laus lossis cov hlwb txawv txav kom tswj tau lub neej zoo.Yog li ntawd, cov ntaub so ntswg thiab lub cev ib txwm tuaj yeem tshawb pom cov hlwb apoptotic txhua lub sijhawm.Txawm li cas los xij, thaum muaj ntau lub hlwb raug apoptosis vim yog lwm yam, kev ua haujlwm ntawm cov ntaub so ntswg thiab cov kabmob yuav raug cuam tshuam.

Daim duab 4 qhia txog cov xwm txheej apoptosis ntawm nas raum cov ntaub so ntswg hauv txhua pab pawg.Qhov tsaus nti xim, qhov ntau dua ntawm apoptosis.Pom tseeb, cisplatin tuaj yeem ua rau muaj ntau lub raum cell apoptosis, tab sis lub raum hlwb tiv thaiv los ntawm Ganoderma lucidum muaj kev tiv thaiv zoo rau apoptosis los ntawm cisplatin.Thaum tus naj npawb ntawm lub raum tuag txo qis, qib ntawm lub raum raug mob raug txo, thiab lub raum ua haujlwm tsis zoo.

Fig. 4 Cov teebmeem ntawm cisplatin thiabGanoderma lucidumntawm lub raum cell apoptosis

Tsuas yog los ntawm kev tiv thaiv lub siab thiab lub raum tuaj yeem muaj kev cia siab ntawm kev kov yeej mob qog noj ntshav.

Kev siv tshuaj khomob yog qhov tseemceeb tshaj plaws thiab tsim nyog txhais tau tias kho mob qog noj ntshav, tab sis "ob npaug-edged" yam ntxwv ntawm kws khomob uas tua cov kabmob kheesxaws thiab ua rau cov hlwb tsis zoo rau txhua tus neeg mob.

Tej zaum lub zog muaj zog tuaj yeem tiv taus xeev siab, ntuav, raws plab, qhov ncauj qhuav, qhov ncauj qhov ntswg thiab lwm yam tsis xis nyob, tab sis lub siab thiab ob lub raum uas metabolize tshuaj tsis tuaj yeem tiv thaiv los ntawm lub siab nyiam.

Thaum tsis muaj lub siab ua haujlwm zoo thiab lub raum, txawm tias kev tshem tawm cov qog nqaij hlav cancer zoo li cas, nws tsis muaj txiaj ntsig.

Cov ntawv, "Lingzhi tuaj yeem txo cov tshuaj tiv thaiv hepatotoxicity" thiab "Lingzhi tuaj yeem txhim kho cov tshuaj tiv thaiv kab mob nephrotoxicity", los ntawm kev sim tsiaj, rov teb cov laj thawj vim li cas cov neeg mob qog noj ntshav tau txais kev kho mob ntxiv nrog Lingzhi tsis yooj yim kov yeej los ntawm toxicity ntawm cov tshuaj kho mob. .

Nws cia siab tias cov pov thawj kev tshawb fawb no tuaj yeem ua rau cov neeg mob ntau dua tuaj yeem noj tauGanoderma lucidumua ntej, thaum lub sij hawm thiab tom qab kws khomob, thiab lawv yuav tsum noj nws txhua hnub.Yog lawv noj txausGanoderma lucidumtxhua txhua hnub, toxicity ntawm chemotherapy rau lub siab thiab ob lub raum yuav daws tau los ntawmGanoderma lucidumthawj zaug.

[Cov ntaub ntawv Source]

1. Yasmen F Mahran, et al.Ganoderma lucidumTiv thaiv Cisplatin-Induced Nephrotoxicity los ntawm Inhibition ntawm Epidermal Growth Factor Receptor Signaling thiab Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.Xyoo 2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, et al.Kev Tiv Thaiv Cisplatin-Induced Hepatic Injury hauv nas Los ntawm Alarmin High-Mobility Group Box-1 Txoj Kev los ntawmGanoderma lucidum: Theoretical and Experimental Study.Drug Des Devel Ther.2020;14: 2335–2353.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv

txij li xyoo 1999. Nws yog tus sauKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB ★ Cov haujlwm saum toj no tsis tuaj yeem luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb ★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv lub Scope ntawm kev tso cai thiab qhia lub hauv paus: GanoHerb ★ Kev ua txhaum ntawm cov lus saum toj no, GanoHerb yuav caum nws cov luag hauj lwm raws li txoj cai ★ Thawj cov ntawv nyeem ntawm tsab xov xwm no yog sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.

Dhau ntawm Millennia Health Culture

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