Wu Tingyao

I ka waena o 2020, ua hui pū nā hui noiʻi o Delta University for Science & Technology a me Ain Shams University ma ʻAigupita i ka paʻi ʻana i nā hōʻike ma "Drug Design, Development and Therapy" a me "Oxidative Medicine and Cellular Longevity" e hōʻike ana i kēlā.Ganodermalucidum(i kapa ʻia ʻo Lingzhi a i ʻole Reishi mushroom) hiki ke hōʻemi nui i ka ʻeha a me ka hōʻeha puʻupaʻa i hana ʻia e cisplatin ma o nā hopena triple o ka anti-oxidation, anti-inflammation a me anti-apoptosis.

Ma hope o ka "Mahele 1ʻO Ganoderma lucidumpale i ka ate vs. cisplatin hepatotoxicity” o ka ʻatikala mua, e hoʻolauna ka mea kākau i ka nuiʻO Ganoderma lucidum'O ka hopena pale-ki'i hiki ke pale aku i ka nephrotoxicity i ho'okumu 'ia e cisplatin i loko o kēia 'atikala me ka mana'olana 'o ka 'ikepili a me nā hō'ike e pili ana i ka 'epekema e lawe mai i ka hilina'i hou a'e i nā hoa e 'imi nei e ho'emi i ka hopena o ka chemotherapy.

Mahele 2ʻO Ganoderma lucidum pale i ke kīpē vs. Cisplatin nephrotoxicity

E like me ka hoʻokolohua holoholona ma "ʻO Ganoderma lucidumpale i ke akepaʻa vs. Cisplatin hepatotoxicity", ua māhele ʻia nā ʻiole olakino i 6 mau pūʻulu no kahi hoʻokolohua 10 lā ma "ʻO Ganoderma lucidumpale i ke kīpē vs. Cisplatin nephrotoxicity”:

◆ Pūʻulu Mana (Cont): ka hui i loaʻa ʻole kahi lapaʻau;
◆ʻO Ganoderma lucidumPūʻulu (GL): ka hui i hoʻopaʻa ʻole ʻia me cisplatin akā ʻaiʻO Ganoderma lucidumnā lā āpau;
◆Cisplatin Group (CP): ka hui i hoʻopaʻa ʻia me ka cisplatin akā ʻaʻole ʻai.ʻO Ganoderma lucidum;
◆ Pūʻulu i kēlā me kēia lā (i kēlā me kēia lā): ka hui i hoʻopaʻa ʻia me ka cisplatin a ʻai.Ganoderma Lucidumnā lā āpau;
◆Every Other Day Group (EOD): ka hui i hoʻopaʻa ʻia me ka cisplatin a ʻai.Ganoderma Lucidumi kēlā me kēia lā;
◆ Pūʻulu Intraperitoneal (ip): ka hui i hoʻopaʻa ʻia i ka cisplatin a loaʻa i ka hoʻokele intraperitoneal oʻO Ganoderma lucidum.

ʻO ka poʻe a pau i loaʻa i ka cisplatin ua hoʻokomo ʻia i loko o ka intraperitoneally me 12 mg / kg o Cisplatin i ke kolu o ka lā o ka hoʻokolohua e hoʻoulu ai i ka ʻeha ʻeha ʻeha;ka poe i loaa i ka intraperitoneal injection oʻO Ganoderma lucidumua hoʻokomo ʻia i hoʻokahi manawa ma ka lua a me ke ono o nā lā o ka hoʻokolohua.No na hui i aiʻO Ganoderma lucidum, inā paha lākou i ʻai ia i kēlā me kēia lā a i kēlā me kēia lā, ua helu ʻia mai ka lā mua o ka hoʻokolohua.

I nā huaʻōlelo ʻē aʻe, ma kēia hoʻolālā hoʻokolohua, loaʻa nā hui āpau i cisplatin aʻO Ganoderma lucidumua haawiiaʻO Ganoderma lucidumma mua o ka hoʻokomo ʻana i ka cisplatin.He ʻokoʻa iki kēia mai ka hoʻokolohua holoholona ma “ʻO Ganoderma lucidumpale i ka ate vs.ʻO Ganoderma lucidumhoʻohana pū ʻia mai ka hoʻomaka ʻana, a i ʻole cisplatin i hāʻawi mua ʻia a lailaʻO Ganoderma lucidum).

ʻO kaʻO Ganoderma lucidumʻo ka mea i hoʻohana ʻia i kēia hoʻokolohua like me kaʻO Ganoderma lucidummea i hoʻohana ʻia i ka hoʻokolohua holoholona ma “ʻO Ganoderma lucidumpale i ka ate vs. Cisplatin hepatotoxicity”.Loaʻa iā lākou nā triterpenes, sterols, polysaccharides, polyphenols a me nā flavonoids.ʻO ka nui oʻO Ganoderma lucidumi hāʻawi ʻia, inā ma ka waha a i ʻole ma ke ʻano he 500 mg/kg i kēlā me kēia lā.

(1) Hoʻemi ʻo Ganoderma lucidum i ka hōʻeha ʻana i ka ʻiʻo ʻāʻī

Ma hope o ka hoʻokolohua 10-lā, huki ʻia ke koko e ʻike i ka ʻiole creatinine a me ke koko urea nitrogen o nā ʻiole i kēlā me kēia hui.Ua ʻike ʻia nā hopena ua hoʻonui nui ʻia ka cisplatin i kēia mau ʻōlelo kuhikuhi ʻelua, ʻo ia hoʻi, ua ʻeha nui ka ʻiʻo kīkī;inaʻO Ganoderma lucidumhoʻohana ʻia i ka manawa like, e hoʻemi nui ʻia ka piʻi ʻana o kēia mau hōʻailona ʻelua, ʻoi aku ka ʻaiʻO Ganoderma lucidumi kēlā me kēia lā e hoʻopuka i kahi hopena pale ʻoi aku ka maopopo (Fig.

1).

Fig. 1Nā hopena o Cisplatin a meGanodermalucidum ma ka Papa Kuhikuhi Poino

Ua hōʻike pū ʻia nā hopena like ma nā ʻāpana ʻeleʻele o nā ʻiʻo o nā ʻiole i kēlā me kēia hui (Fig. 2).I ka wā e hoʻoulu ai ka cisplatin i ka renal congestion, renal tubule dilatation, a me necrosis, shedding, or vacuolar degeneration of renal tubular epithelial cell in its (he mau pua like ʻole e hōʻike ana i ka hōʻeha ʻana i ke kiʻi o ka ʻāpana i hoʻopaʻa ʻia), nā ʻiʻo o nā ʻiole o kēlā me kēia lā. ʻO kēlā me kēia lā) loaʻa ka ʻeha liʻiliʻi loa (ʻaʻohe pua e hōʻike ana i nā ʻeha ma ke kiʻi o ka ʻāpana ʻeleʻele).

Ma muli o ka hōʻiliʻili ʻana o cisplatin i loko o nā epithelial cell o ka renal tubules i ka nui, ʻo ka ʻeha o nā tubules renal e lilo maoli i mea ʻike nui.Hiki ke ʻike maopopo ʻia mai ka helu helu o ka ʻeha tubular renal i kēlāʻO Ganoderma lucidumhiki ke hōʻemi nui i ka ʻeha tubular renal i hana ʻia e cisplatin.ʻO ka mea nui, ʻaiʻO Ganoderma lucidumi kēlā me kēia lā e hoʻopuka i ka hopena pale koʻikoʻi.

ʻO T pili i nā tubules renal aʻo G e pili ana i ka glomeruli ma nā kiʻi o nā ʻāpana kiko;kuhikuhi ka pua i ka ʻāʻī o ka renal, ka hoʻomāhuahua ʻana o ka tubular, ka necrosis, ka hoʻoheheʻe ʻana, a i ʻole ka degeneration vacuolar o nā pūnaewele epithelial tubule renal ma muli o ka ʻeha o ka ʻiʻo renal.

Fig.2 Nā hopena o Cisplatin a meʻO Ganoderma lucidumma ka ʻiʻo kīkī

(2)ʻO Ganoderma lucidumhoʻonui i ka mana anti-oxidative a me ka anti-inflammatory o ka ʻiʻo ʻiʻo

ʻO ka pōʻino o ka cisplatin i ka ʻiʻo ʻāʻī e pili ana i ka hōʻeha oxidative a me ka ʻeha ʻeha.Mai ka helu oxidation (H₂O₂), antioxidant index (SOD), and inflammation index (HMGB-1) i ana i loko o nā ʻiʻo o nā ʻiole i loko o kēlā me kēia hui, hiki ke ʻike ʻia e hiki ke hoʻemi ʻia ka ʻeha oxidative a me ka ʻeha ʻeha i hana ʻia e cisplatin e ka hoʻohana pū ʻana oʻO Ganoderma lucidum(Fig.

3).

Fig.3 Nā hopena o cisplatin a meʻO Ganoderma lucidume pili ana i ka oxidation a me ka mumū o ka ʻiʻo ʻiʻo

(3)ʻO Ganoderma lucidumhoʻonui i ka mana anti-apoptotic o nā pūnaewele

ʻO ka manaʻo ʻole o ka cisplatin ke kumu o ka make ʻana o ka cell kidney ma o ka hōʻeha oxidative a i ʻole ka hōʻeha ʻeha, ʻo ke ʻano o ka make ʻana o nā cell kidney he "apoptosis."

ʻO ka ʻoiaʻiʻo, ʻo ka apoptosis ke ʻano hana maʻamau o ke kino e hoʻopau i ka ʻelemakule a i ʻole nā ​​​​pūnaewele maʻamau i mea e mālama ai i ka maikaʻi o ke ola.No laila, hiki i nā ʻiʻo maʻamau a me nā kino ke ʻike i nā cell apoptotic i kēlā me kēia manawa.Eia nō naʻe, i ka wā e loaʻa ai ka nui o nā cell apoptosis ma muli o nā kumu o waho, e hoʻopilikia ʻia ka hana maʻamau o nā ʻiʻo a me nā kino.

Hōʻike ka Fig. 4 i ke kūlana apoptosis o nā ʻiʻo ʻiole i loko o kēlā me kēia hui.ʻOi aku ka ʻeleʻele o ka waihoʻoluʻu, ʻoi aku ka nui o ka apoptosis.ʻIke loa, hiki i ka cisplatin ke hoʻoulu i ka nui o ka apoptosis cell renal, akā ʻo nā cell renal i pale ʻia e Ganoderma lucidum he kūʻē maikaʻi i ka apoptosis i hoʻokumu ʻia e cisplatin.Ke emi ka helu o nā pūkini make, hoʻemi ʻia ke kiʻekiʻe o ka hōʻeha puʻupaʻa, a emi iki ka hana ʻana.

Fig. 4 Nā hopena o cisplatin a meʻO Ganoderma lucidume pili ana i ka apoptosis cell renal

Ma ka pale ʻana i ke ake a me nā puʻupaʻa wale nō e loaʻa ai ka manaʻolana o ka lanakila ʻana i ka maʻi kanesa.

ʻO Chemotherapy ka mea maʻamau a pono e mālama i ka maʻi kanesa, akā ʻo ke ʻano "ʻelua-ʻaoʻao" o ka chemotherapy e pepehi ai i nā maʻi maʻi a hōʻino i nā cell maʻamau ʻaʻole hiki ke hoʻomanawanui i nā maʻi āpau.

Hiki paha i ka makemake ikaika ke pale i ka nausea, ka lua'i, ka ma'i ma'i, ka waha malo'o, ka ma'i ma'i waha a me nā pilikia 'ē a'e, akā, 'a'ole hiki ke pale 'ia ke ake a me nā pu'upa'a e ho'ololi i nā lā'au e ka mana'o ikaika.

I ka wā ʻaʻohe hana maikaʻi o ke ake a me nā puʻupaʻa, ʻaʻohe mea e pili ana i ka pau ʻana o ka hoʻopau ʻana i nā maʻi maʻi maʻi, he mea ʻole ia.

ʻO nā ʻatikala, "Hiki i ka Lingzhi ke hoʻomaikaʻi i ka hepatotoxicity i hoʻohana ʻia i ka lāʻau" a me "Lingzhi hiki ke hoʻomaikaʻi i ka nephrotoxicity i hoʻohana ʻia i ka lāʻau", ma o nā hoʻokolohua holoholona, ​​ua pane hou i nā kumu i hiki ʻole ai i nā poʻe maʻi maʻi ke loaʻa i ka chemotherapy adjuvant me Lingzhi i ka maʻalahi o ka make o nā lāʻau lapaʻau chemotherapy .

Manaʻo ʻia e hiki i kēia mau hōʻike ʻepekema ke hōʻoiaʻiʻo i nā poʻe maʻi e hiki iā lākou ke ʻaiʻO Ganoderma lucidumma mua, i ka wā a ma hope o ka chemotherapy, a pono lākou e ʻai i kēlā me kēia lā.Inā lawa lākou e ʻaiʻO Ganoderma lucidumi kēlā me kēia lā, hiki ke hoʻoholo ʻia ka ʻona o ka chemotherapy i ke ake a me nā puʻupaʻa eʻO Ganoderma lucidumi ka manawa mua.

[Kumu ʻikepili]

1. Yasmen F Mahran, et al.ʻO Ganoderma lucidumKāohi ʻo Cisplatin-Induced Nephrotoxicity ma o ke kāohi ʻana i ka Epidermal Growth Factor Receptor Signaling a me Autophagy-Mediated Apoptosis.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanana M Hassan, et al.Hoʻopau ʻia ʻo Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway eʻO Ganoderma lucidum: Haʻawina Manaʻo a hoʻokolohua.Drug Des Devel Ther.2020;14: 2335–2353.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike

mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka GanoHerb ★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, Pono e hoʻohana ʻia i loko o ke ʻano o ka ʻae ʻia a hōʻike i ke kumu: GanoHerb ★ ʻAi ʻole i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i kāna mau kuleana pili kānāwai ★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Kina e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.

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