Umehluko omkhulu phakathiLingzhi(ebizwa nangokuthiI-Ganoderma lucidumnoma i-Reishi mushroom) noma imithi ye-Lingzhi nokunye ukudla okuningi kwezempilo ukuthi njengoba i-Lingzhi iphumelela kokhokho kanye nomphakathi jikelele owayidla kusukela ezikhathini zasendulo kuze kube manje, ososayensi basebenzisa ukuhlolwa kwezilwane namangqamuzana ukuze baqonde ukuthi kungani i-Lingzhi iphumelela esikhundleni sokuthi ukumema umphakathi ukuthi uthenge ucezu lwengqondo ngemva kokuthola amandla okwelapha e-Lingzhi ekuhlolweni kwamaseli nezilwane.

Okufanayo kuyiqiniso nge-Lingzhi ekusetshenzisweni kwe-anti-tumor.Ngakho-ke, ucwaningo lososayensi mayelana nomphumela we-anti-tumor we-Lingzhi lungaqhubeka nokusungula emazweni emhlabeni jikelele iminyaka engaphezu kwengu-50 kusukela ngo-1986 lapho umbiko wokuqala wocwaningo owafakazela umphumela wokulwa nesimila we-Lingzhi ushicilelwe ngokomlando yiNational National. I-Cancer Center Research Institute yaseJapan.

Wonke umuntu kufanele ukuthi ufunde ucwaningo oluningi lokuthi i-Lingzhi ingalwa kanjani nomdlavuza wamaphaphu, umdlavuza wesibindi, umdlavuza wamathumbu kanye nomdlavuza webele emzimbeni, kodwa bewazi yini ukuthi i-Lingzhi ingalwa nomdlavuza wesisu?!

Umbiko oshicilelwe kumaMolekuli nguSolwazi Hyo Jeung Kang, eKyungpook National University's College of Pharmacy ngo-Okthoba 2019, ukuqinisekisile ukuthi i-triterpenoid-richI-Ganoderma lucidumi-fruiting body ethanol extract (okubizwa ngokuthi i-GLE kulolu cwaningo) ingavimbela ukukhula kwezimila zesisu emzimbeni.

Umthelela weI-Ganoderma lucidumumthamo

Abacwaningi baqale bafaka imigqa yamaseli omdlavuza wesisu emhlane wamagundane angenawo amasosha omzimba (amagundane anqunu).Ngemva kwamasonto amabili okukhula kwesimila, amagundane aphathwa ngomlomoI-Ganoderma lucidumI-ethanol ikhipha i-GLE ngethamo lansuku zonke lama-30 mg/kg.

Lapho ukuhlolwa kuqhubekela osukwini lwama-23, izinga lokukhula kwesimila se-I-Ganoderma lucidumiqembu (ijika eliluhlaza ku-Fig. 1) ngokusobala lalihamba kancane kakhulu kuneqembu lokulawula (ijika elimnyama ku-Fig. 1) elingazange lithole ukwelashwa.

Umfanekiso 1 Umthamo omkhuluI-Ganoderma lucidumUkukhishwa kwe-ethanol kungavimbela ukukhula kwezimila zesisu

Nokho, uma i-I-Ganoderma lucidumukukhishwa kwe-ethanolI-GLE enikezwa ngomlomo kumagundane iyancipha ibe ingxenye eyodwa kwezintathu, okungukuthi kuphela i-10 mg/kg ngosuku, izinga lokukhula kwesimilaI-Ganoderma lucidumiqembu (ijika eliluhlaza ku-Figure 2) licishe lifane neleqembu lokulawula elingalashiwe (ijika elimnyama kuMfanekiso 2).

Umfanekiso 2 Umthamo ophansiI-Ganoderma lucidumUkukhishwa kwe-ethanol akukwazi ukuvimbela ukukhula kwezimila zesisu

Ngamanye amazwi, emva kwe-I-Ganoderma lucidum I-ethanol ekhishwayo iyagaywa futhi ingene emgudwini wamathumbu, ingavimbela ngempela izimila zesisu emzimbeni ongenawo amandla omzimba, kodwa lo mphumela usekelwe, okungukuthi, umthamo kufanele wanele;uma umthamo unganele, kungase kube nesiphetho sokuthi "ukudla i-Lingzhi kungasebenzi".

Umphumela wokuhlanganisa okukodwa akusho ukuthi mkhulu kunokubili.

Lolu cwaningo luphinde lwaxoxa ngomphumela we-synergistic we-quercetin (QCT, i-flavonoid etholakala kabanzi ezithelweni ezihlukahlukene, imifino kanye namatiye) kanyeI-Ganoderma lucidumi-ethanol ekhishwe ekuvimbeleni izimila zesisu.

Umsebenzi we-antioxidant we-quercetin unikeza ingxenye yesisekelo sesayensi sokuthi "ukudla okwanele kwezithelo nemifino kunganciphisa ingozi yomdlavuza".Ngakho-ke, inhlanganisela ye-quercetin kanyeI-Ganoderma lucidumkufanele ikwazi ukudlala indima yokukodwa kanye nokukodwa okukhulu kunokubili, akunjalo?

Uma uzimisele ukubheka emuva emiphumeleni yokuhlolwa kwezilwane okwethulwa kuMfanekiso 1 no-2, akunzima ukuthola lowo mphumela wedosi ephezulu (30 mg/kg ngayinye) ye- “I-Ganodermalucidum+ i-quercetin” ayingcono kunokusebenzisa eyodwa yazo iyodwa.Nakuba umphumela womthamo ophansi (10 mg/kg ngalinye) we “I-Ganodermalucidum+ i-quercetin” ingcono kunokusebenzisa umthamo ophansiI-Ganoderma lucidumiyodwa noma leyo yokusebenzisa umthamo ophansi we-quercetin iyodwa, lo mphumela omuhle awuhlukile emphumeleni “wokusebenzisa umthamo omkhulu.I-Ganodermalucidumyedwa”.

Okusho ukuthi, ngokombono wemvelo yomuntu, sifuna njalo "ukwengeza okuthile" ukuthuthukisa umphumela wokulwa nomdlavuzaI-Ganoderma lucidum.Kodwa-ke, kusukela emiphumeleni yesayensi, inhlanganisela efana nalokhu okungenhla ingase ingabi kuhle njengokuthi "ukudla i-Ganoderma lucidum yodwa".Ukudla okuvamile kweI-Ganoderma lucidumkanye nokudla okufanele kwansuku zonke kungasiza imizimba yethu ukuba ibe namandla amahle okuzilapha umdlavuza.

Igciwane le-Epstein-Barr elingahlala ngokuthula noma libangele umdlavuza

Kuyafaneleka ukubalula ukuthi ulayini wamangqamuzana omdlavuza wesisu womuntu i-MKN1-EBV osetshenziswe esivivinyweni sezilwane esishiwo ngenhla iseli lomdlavuza wesisu elinegciwane le-Epstein-Barr (EBV).Cishe u-10% weziguli ezinomdlavuza wesisu zingalolu hlobo lomdlavuza wesisu ohlobene negciwane le-EB “ongahlolwa ukuthi unegciwane le-EB ezicutshini zomdlavuza”.

Eqinisweni, abantu abadala abaningi baye bangenwa igciwane le-Epstein-Barr bengazi, ngenxa yokuthi lapho lihlasela amangqamuzana e-B asezicutshini ze-mucosal ngokusebenzisa i-oral mucosa (amathe), lizocasha kuma-B cell esimweni sokulala futhi lihlala ndawonye. ngokuthula nomuntu onaleli gciwane impilo yakhe yonke.

Bambalwa kuphela abantu abazophathwa umdlavuza wesisu, umdlavuza wenasopharyngeal noma i-lymphoma ngenxa yegciwane le-Epstein-Barr.Ukungasebenzi kahle kwamasosha omzimba kuwukhiye wegciwane le-Epstein-Barr ukuze liphule ibhalansi futhi libangele umdlavuza.

Ngakho-ke, kunamagciwane amaningi abantu okufanele bawafunde ukuhlalisana ngokuthula!Ukuze ube nokuthula nalaba bahlaseli ngasikhathi sinye, indlela elula iwukugcina impilo ngeI-Ganoderma lucidumngobaI-Ganoderma lucidumiqukethe kokubili ama-polysaccharides angalawula ukuzivikela komzimba kanye nama-triterpenes angavimbela ukwanda kwegciwane.

Uma kwenzeka umdlavuza ngeshwa, kungcono ukudlaI-Ganoderma lucidumngoba ngalesi sikhathi umzimba awudingi nje kuphela ama-polysaccharides ukuze uthuthukise amasosha omzimba ukuze ulwe namangqamuzana omdlavuza kodwa futhi udinga ama-triterpenes ukuze alwe namangqamuzana omdlavuza.

Ucwaningo lwaseKorea olubalwe ngenhla lufakazele ukuthi i-triterpene-richI-Ganoderma lucidumUkukhishwa kwe-ethanol kungavimbela ukukhula kwezimila zesisu ezihlobene negciwane le-Epstein-Barr emzimbeni ngokuqondile ngoba kungabhebhethekisa leli gciwane kumaseli omdlavuza ukuthi ligoqe amangqamuzana omdlavuza ngaphandle kokulimaza amaseli avamile.Phakathi kwazo, isithako esiyinhloko esiqondisa "ukulwa nobuthi obunobuthi" yi-ganoderic acid A ku-triterpene.I-Ganoderma lucidum.

NgenkathiI-Ganoderma lucidumama-triterpenes afana ne-ganoderic acid A aya ngaphambili ukuze abulale isitha,I-Ganoderma lucidumama-polysaccharides anakekela ingemuva ngokuqinisa amasosha omzimba.Ingabe akuqinisekile ngokwengeziwe ukuwina ukunqoba okuhle?

Ngakho singakwazi ukufunda futhi sihlole izithako ezahlukeneI-Ganoderma lucidum.Kodwa uma udlaI-Ganoderma lucidum, qiniseka ukuthi uyakhethaI-Ganoderma lucidumngezithako ezisebenzayo eziphelele.Kuphela enjaloI-Ganoderma lucidumingakwazi ukulinganisa umugqa wangaphambili kanye nendawo yangemuva futhi ifinyelele umphumela oyifunayo.

[Umthombo Wedatha]

Sora Huh, et al.I-Quercetin I-Synergistically Inhibit EBV-Associated Gastric Carcinoma ene-Ganoderma lucidum Extracts.Amangqamuzana.2019 Okthoba 24;24(21): 3834. doi: 10.3390/molecules24213834. (https://www.mdpi.com/1420-3049/24/21/3834)

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi bungeka-GANOHERB ★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kokugunyazwa kwe-GanoHerb ★ Uma imisebenzi igunyaziwe ukuthi isetshenziswe, kufanele isetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ibonise umthombo: GanoHerb ★ Ukwephulwa kwesitatimende esingenhla, i-GanoHerb izoqhuba izibopho zayo ezingokomthetho ezihlobene ★ Umbhalo wokuqala wale ndatshana ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.

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