Januwari 8, 2016/ Chinese Academy of Medical Sciences kanye ne-Peking Union Medical College/ Frontiers in Microbiology

Umbhalo/Wu Tingyao

Kumelwe ukuba uke wambona umlingisi odabukisayo emdlalweni weshashalazi owakhwehlela isikhathi eside waze wakhwehlela igazi eligcwele emlonyeni kokunye kokukhwehlela kwakhe okubi kakhulu ……Kwatholakala ukuthi unesifo sofuba futhi kwadingeka abekwe yedwa ukuze angasabalalisi lesi sifo. abanye.Ngokungenelela kokuqala kwemithi yesimanje, bambalwa abantu abagula kakhulu, kodwa umlandu,Mycobacterium isifo sofuba, wayesekulungeleqalisa okukhuluukuhlasela lapho amasosha omzimba esengozini.Manje, kwafika izindaba ezinhle ezivela eChinaI-Ganoderma lucidum inhlamvus kanye ne-sporelipids Ingase ivimbele i-prophylacticallyMycobacterium isifo sofuba.

Ucwaningo olwanyatheliswa yi-Chinese Academy of Medical Sciences kanye ne-Peking Union Medical College ku- "Frontiers in Microbiology" ngoJanuwari 2016 lwabonisa ukuthi ukuphathwa kokuvimbelaI-Ganoderma lucidum khipha (inhlamvus kanye ne-sporelipid)ingavimbela ukuphindaphinda nokwanda kweI-Mycobacterium Tuberculosis kumagundane futhi unciphise inaniI-Mycobacterium Tuberculosis emaphashini nasebeni lwamagundane.

Zonke izifo ezibangelwaI-Mycobacterium Tuberculosis zibizwa zizonke ngokuthi “isifo sofuba”.I-Mycobacterium Tuberculosis isakazwa kakhulu ngamaconsi.Itheleleka kakhulu ezindaweni ezivalekile nasemabangeni aseduze.Noma yiziphi izicubu nezitho zomzimba wethu zingase zibe negciwane.Nokho,“Isifo sofuba” esibangelwa ukutheleleka emaphashini yisona esivame kakhulu.Abantu abanesifo sofuba esibi bazofa ngenxa yokulimala kwamaphaphu abo.

Uma sithatha izibalo zaseTaiwan ngo-2012 njengesibonelo, inani labantu abafa ngenxa yesifo sofuba ngalowo nyaka lalingaphezu kuka-600, okwakuphindwe kashumi inani lokufa okubangelwa abakwaSARS ngo-2003. U-SARS uza kanye ngezikhathi ezithile, kodwa isifo sofuba sihlala sikhona. .Kuthiwa isifo sofuba asikaze sinyamalale kusukela kudalaI-Neolithic Ubudala.Noma ngabe ukusungulwa kwe-BCG kwalawula izinga lokutheleleka, kodwa namanje ayikakuvimbi ngokuphelele usongo lwesifo sofuba esintwini.Kufanele siqaphengokumelene nayo.

Ungacabangi ukuthi isifo sofuba asihlangene nawe.Kuyaqondakala ukuthi cishe ingxenye eyodwa kwezintathu yabantu emhlabeni wonke inesifo sofuba.Mina nawe singase sibe ngomunye wabo.Ukuthi nje iningi labantu abanaleli gciwane alinazo izimpawu (ukukhwehlela isikhathi eside isikhathi esingaphezu kwenyanga, ukuncipha kwesisindo, imfiva nokujuluka ebusuku) kanye “nokutheleleka kwesifo sofuba esicashile” esithathelwanayo esincane.

Eqinisweni, inqobo nje uma i-immunity yanele,I-Mycobacterium Tuberculosis ingagcinwa esimweni "sokungasebenzi".Inkinga iwukuthi lapho amasosha omzimba esengozini, ikakhulukazi lapho ethola ukwelashwa nge-radiotherapy, nge-chemotherapy, noma etheleleke nge-HIV,I-Mycobacterium Tuberculosis angase abe nethuba elikhulu lokuhlasela.Ngakho-ke, indlela yokugwema ukutheleleka kanye nendlela yokuyicindezela ngokuphumelelayo ngemva kokutheleleka kugxile ekuvimbeleni nasekwelapheni isifo sofuba.

Ithimba labacwaningi be-Chinese Academy of Medical Sciences kanye ne-Peking Union Medical College baqale basebenzisa amagundane e-C57BL/6 kanye nenani elincaneI-Mycobacterium Tuberculosis ukusungula imodeli yokuhlola yezilwane efana "nokutheleleka kwesifo sofuba esicashile", futhi kwaqhubeka nokuhlola umphumela wokulwa nesifo sofubaI-Ganoderma lucidum.Ithimba lithole ukuthi:

Ngenkathi amagundane angenweI-Mycobacterium Tuberculosis, baphathwa kanyekanyeI-Ganoderma lucidum amalungiselelo (15 mg spores kanye no-15 mg we-sporeamafutha zathathwa ngomlomo usuku ngalunye amasonto angu-16, kwase kuphelile ukuhlola), inani leI-Mycobacterium Tuberculosis emaphashini nasebeni lamagundane kwakungahlukanga kulelo qembu elingalashwanga.Nokho, uma umthamo ofanayoI-Ganoderma lucidum inganikezwa amagundane inyanga eyodwa ngaphambi kokuqala kokuhlolwa (ukutheleleka), inganciphisa ngempumelelo inaniI-Mycobacterium Tuberculosis emaphashini nasebeni lamagundane.Ikakhulukazi emasontweni amathathu kuya kwamahlanu okuqala laphoI-Mycobacterium Tuberculosis ingena emzimbeni wegundane, umphumela wokuvimbela ubaluleke kakhulu.

Kuphinde kwabonwa esivivinyweni ukuthi kwakungekho ukuhlobana phakathi kwenani lamaseli omzimba egazini le-peripheral lamagundane, inani lokusabalala kwamagundane.I-Mycobacterium Tuberculosis, kanye nobukhulu bezilonda zamaphaphu nobende.Nokho, emagundeni ayedlaI-Ganoderma lucidum amalungiselelo ngaphambi kokutheleleka, phakathi namasonto amathathu kuya kwayisihlanu ngemva kokutheleleka ngesifo sofuba iMycobacterium, amangqamuzana e-dendritic egazini le-peripheral ehla kakhulu, futhi amangqamuzana e-dendritic emaphashini anda kakhulu.Lesi simo singase sichaze ngokwengxenye ukuthi kungani udla ngaphambi kwesikhathiI-Ganoderma lucidum ingavimbela iI-Mycobacterium Tuberculosis emaphashini amagundane.

[Umthombo]UZhan L, et al.Ukusetshenziswa kwe-prophylactic ye-Ganoderma lucidum extract kungase kuvimbele ukuphindaphinda kwesifo sofuba se-Mycobacterium kumodeli yegundane entsha yokutheleleka kwesifo sofuba esicashile okuzenzakalelayo.I-Microbiol yangaphambili.2016 Jan 8;6:1490.doi: 10.3389/fmicb.2015.01490.eCollection 2015.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.