NgoJanuwari 8, 2016 / iAcademy yaseTshayina yeSayensi yezoNyango kunye nePeking Union Medical College / Frontiers kwiMicrobiology

Umbhalo/Wu Tingyao

Umele ukuba ukhe wambona omnye umlinganiswa olusizi kumdlalo weqonga owakhohlela ixesha elide kangangokuba wakhohlela igazi elininzi kolunye ukhohlokhohlo lwakhe oluqatha ……Kwafunyaniswa ukuba unesifo sephepha kwaye kwafuneka abekwe yedwa ukuze angasasazeki esi sifo kuye. abanye.Ngokungenelela kwangaphambili kwamayeza anamhlanje, bambalwa abantu abagula kakhulu, kodwa unobangela,Misifo sephepha ycobacterium, wayekulungeleqalisa enkuluukuhlaselwa xa amajoni omzimba esengozini.Ngoku, kwavela iindaba ezilungileyo ezivela eTshayinaI-Ganoderma lucidum i-spores kunye ne-sporelipids inokuthi ithintele iprophylacticallyMisifo sephepha ycobacterium.

Uphononongo olupapashwe yi-Chinese Academy of Medical Sciences kunye ne-Peking Union Medical College kwi-"Frontiers in Microbiology" ngoJanuwari 2016 ibonise ukuba ulawulo lokuthintelaI-Ganoderma lucidum isicatshulwa (i-spores kunye ne-sporelipid)inokuthintela uphindaphindo kunye nokwanda kweIsifo sephepha seMycobacterium kwiimpuku kunye nokunciphisa inaniIsifo sephepha seMycobacterium kwimiphunga kunye nodaka lwempuku.

Zonke izifo ezibangelwaIsifo sephepha seMycobacterium ngokudibeneyo zibizwa ngokuba “sisifo sephepha”.Isifo sephepha seMycobacterium isasazwa ikakhulu ngamathontsi.Isosulela kakhulu kwiindawo ezivaliweyo kunye nemigama ekufutshane.Naziphi na izihlunu kunye namalungu emzimbeni wethu anokosuleleka.Nangona kunjalo,“Isifo sephepha” esibangelwa kukosuleleka kwemiphunga sesona sixhaphakileyo.Abantu abanesifo sephepha esinzima baya kufa ngenxa yomonakalo kwimiphunga yabo.

Xa sithatha iinkcukacha-manani zaseTaiwan ngo-2012 njengomzekelo, inani labantu ababhubhileyo ngenxa yesifo sephepha kuloo nyaka lalingaphezu kwama-600, eliliphinda kalishumi inani lokufa okubangelwa yi-SARS ngo-2003. I-SARS iza kanye ngamaxesha athile, kodwa isifo sephepha sisoloko sikhona. .Kuthiwa isifo sephepha asizange siphele kwakudalaNeolithic Ubudala.Nokuba ukuveliswa kwe-BCG kulawule ubungakanani bosulelo, kodwa ayikasithinteli ngokupheleleyo isoyikiso sesifo sephepha eluntwini.Kufuneka silumkengokuchasene nayo.

Musa ukucinga ukuba isifo sephepha asinanto yakwenza nawe.Kuyaqondwa ukuba isinye kwisithathu sabemi behlabathi bosulelwe sisifo sephepha.Mna nawe sisenokuba ngomnye wabo.Kuphela nje uninzi lwabantu abosulelekileyo abanazo iimpawu (ukhohlokhohlo oluthatha ixesha elingaphezu kwenyanga, ukwehla kobunzima bomzimba, umkhuhlane kunye nokubila ebusuku) kunye “nokosuleleka sisifo sephepha esifihlakeleyo” esosulelayo.

Enyanisweni, nje ukuba i-immunity yanele,Isifo sephepha seMycobacterium inokugcinwa kwimo "engasebenziyo".Ingxaki kukuba xa amajoni omzimba ebuthathaka, ngakumbi xa ufumana iradiotherapy, ichemotherapy, okanye wosulelwe yiHIV,Isifo sephepha seMycobacterium unokuba nethuba elikhulu lokuhlasela.Ngoko ke, indlela yokuphepha usulelo kunye nendlela yokuyicinezela ngokufanelekileyo emva kokusuleleka kugxininiso lokuthintela kunye nokunyangwa kwesifo sofuba.

Iqela lophando le-Chinese Academy ye-Medical Sciences kunye ne-Peking Union Medical College yaqala ukusebenzisa iigundane ze-C57BL / 6 kunye nenani elincinci leIsifo sephepha seMycobacterium ukuseka imodeli yovavanyo lwezilwanyana efana "nosulelo lwesifo sephepha esifihlakeleyo" somntu, kwaye siphonononge ngakumbi isiphumo sokulwa nesifo sephephaI-Ganoderma lucidum.Iqela lifumanise ukuba:

Ngelixa iimpuku zosulelwe yiIsifo sephepha seMycobacterium, baphathwa ngaxeshanyeI-Ganoderma lucidum amalungiselelo (15 mg spores kunye ne-15 mg ye-sporelipid zathathwa ngomlomo ngosuku ngalunye kwiiveki ezili-16, emva koko uvavanyo lwaphela), inani leIsifo sephepha seMycobacterium kwimiphunga kunye ne-spleen yeempuku azizange zahluke kwiqela elingaphathwanga.Nangona kunjalo, ukuba umthamo ofanayo weI-Ganoderma lucidum inganikwa iimpuku inyanga enye phambi kokuqala kovavanyo (usulelo), inokunciphisa ngokufanelekileyo inani leempuku.Isifo sephepha seMycobacterium kwimiphunga kunye nodaka lwempuku.Ingakumbi kwiiveki ezintathu ukuya kwezintlanu xaIsifo sephepha seMycobacterium ingena kumzimba we mouse, isiphumo sokuthintela sibaluleke kakhulu.

Kwaye kwaphawulwa kuvavanyo ukuba akukho nxu lumano phakathi kwenani leeseli zokhuselo lomzimba kwigazi leperipheral yeempuku, inani lokwanda kwentsholongwane.Isifo sephepha seMycobacterium, kunye nobungakanani bezilonda zemiphunga kunye ne-spleen.Noko ke, kwiimpuku ezazisityaI-Ganoderma lucidum amalungiselelo phambi kosulelo, kwiiveki ezintathu ukuya ezintlanu emva kokosulelwa Mycobacterium tuberculosis, iiseli dendritic kwi peripheral igazi zehla kabukhali, kwaye iiseli dendritic emiphungeni zanda kakhulu.Le nto inokuchaza ngokuyinxenye ukuba kutheni ukutya kwangaphambiliI-Ganoderma lucidum inokuthintela iIsifo sephepha seMycobacterium kwimiphunga yeempuku.

[Umthombo]UZhan L, kunye nabanye.Ukusetyenziswa kwe-prophylactic ye-Ganoderma lucidum extract kunokuthintela ukuphindaphinda kwesifo sephepha se-Mycobacterium kwimodeli entsha yempuku yosulelo oluzenzekelayo lwesifo sephepha.I-Microbiol yangaphambili.2016 Jan 8;6:1490.doi: 10.3389/fmicb.2015.01490.I-eCollection ka-2015.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi ukususela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali ★ Le misebenzi ingentla ayinakuphinda kuveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali ★ Ukwaphulwa kwale nkcazo ingasentla, umbhali uya kuqhuba uxanduva lwakhe lomthetho olunxulumeneyo ★ Eyokuqala umbhalo weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.