Wu Tingyao

Sezvo mafungiro evanhu vose anochinja-chinja ne“COVID 19 vaccine” uye “COVID 19denda”, chirwere chemaoko-tsoka-ne-muromo, chinowanikwa muvana vari pasi pemakore mashanu, chapindawo munguva huru yedenda.Zviratidzo zvaro zvinowanzobatanidza fivha, maronda emukanwa, uye mapundu eganda anowanzo kuwanikwa pamaoko, muromo, uye/kana tsoka.Chirwere ichi chinokonzerwa nehutachiona hwe enterovirus.

Kune marudzi akawanda e enteroviruses, mazhinji acho ari munyoro uye anogona kucheneswa nekudzivirira muviri mukati mevhiki.Mamwe enteroviruses anogona kuva akanyanya kuoma, achikonzera matambudziko makuru eurological akadai semeningitis, myelitis, acute flaccid paralysis, uye kunyange rufu.

Enterovirus A71, inonzi EV-A71, ndiyo rudzi urwu rwehuipi hunoda kuchengetedzwa zvakanyatsonaka.Sezvinongoita CCIDID-19 yekudzivirira ichidikanwa kudzivirira iyo novel coronavirus, kubaya pasina mubvunzo ndiyo nzira yakanakisa yekudzivirira kutapukirwa neEV-A71.

Nekudaro, sekuziva kwemunhu wese, hapana mushonga unoshanda 100%.Nzira yekuvandudza kushanda kwejekiseni?

Tsvagiridzo yakaburitswa muFrontiers muImmunology, iro gwaro repamutemo reInternational Union of Immunological Societies munaGunyana 2020 neGraduate Institute of Immunology, National Taiwan University College of Medicine, uye Dhipatimendi reKutsvaga Kwekurapa, National Taiwan University Hospital yakasimbisa kuti:

Mushonga weEV-A71 wakawedzerwa neGanoderma lucidumma polysaccharides anogona kusimudzira kugadzirwa kwemasoja ekudzivirira utachiona, kuita kuti hutachiona hwehutachiona huve hunoenderana nehutachiona, hudzvanyire huwandu hwehutachiona mumhuka, kudzivirira kuitika kwehurwere hwakakomba (kupindirwa kwepakati tsinga dzinokonzera acute flaccid paralysis) uye kuderedza njodzi yerufu. .

Mushonga weEV-A71 wakashandiswa mukuyedza mujekiseni usingashandiswe wakagadzirwa nehutachiona husina kuvharwa (hwakafa).Yakasiyana nemajekiseni echinyakare, jekiseni iri rakagadzirwa semadonhwe emumhino, ayo anodonhedzwa zvakananga mumhino uye anotorwa nemukati memuchuchuru kuti akonzere kugadzirwa kwemasoja ekudzivirira chirwere.

Kana zviri zveGanoderma lucidumpolysaccharide yakawedzerwa kumushonga semubatsiri we "kunatsiridza maitiro ekudzivirira-induced immune immune", inotorwa kubva mumvura inopisa yeGanoderma lucidum fruiting miviri, iyo inonzi PS-G (polysaccharide yakanatswa kubva.Ganoderma lucidum) mutsvakurudzo iyi.

Mukuedza kwemhuka, mbeva dzine hutano dzakaiswa 12 μL yekudzivirira madonhwe kubva mumhino dzavo.Iro mbeva dzakakamurwa kuita mapoka matatu zvichienderana nemusiyano mumajekiseni:

◆ RD lysate Boka (No Vaccine Group): chirwere che placebo chinovharidzirwa, chinogona kuonekwa semumiririri wekushaya chirwere;

◆ EV-A71 Group (Vaccine Group): chirwere chekudzivirira chine 2.5 μg ye EV-A71 isina kuvharwa;

◆ EV-A71 + PS-G Boka: nhomba yekudzivirira ine 2.5 μg ye EV-A71 isina kushandiswa uye 20 μg polysaccharide yakacheneswa kubvaGanoderma lucidum(PS-G).

Vhiki mbiri mushure mekunge mbeva dzapedza madosi matatu ekudzivirira, mwero wenguva refu unoshanda masoja ekudzivirira chirwere anorwisa EV71 mumakonzo akaedzwa ─- kusanganisira iyo IgG inowanikwa muserum nemvura yemumuviri, uye IgA iri yechipiri muserum content. uye kunyanya inogara mucosal tissues (oral mucosa, nasal mucosa, breathing mucosa, uye intestinal mucosa).Zvakaonekwa kuti kana zvichienzaniswa nejekiseni iri nyore, jekiseni rinowedzerwa nePS-G rinogona kukurudzira kugadzirwa kwemamwe masoja ekudzivirira eIgG neIgA (Mufananidzo 1), uye masoja ekudzivirira chirwere aya ane maitiro akanaka ekusaurura pamhando dzakasiyana dzeEV71 subtype, uye inewo yakasimba inhibitory effect pamasero ane utachiona (Mufananidzo 2).

Mushonga wakanaka haufanire kungokurudzira kugadzirwa kwemasoja ekudzivirira chirwere asiwo kukurudzira kugadzirwa kwe "memory B cells" kuitira kuti kana hutachiona huchingopinda, hunogona kutanga kubudisa masoja ekudzivirira chirwere kuti awedzere mauto matsva epamberi pasina kushandisa mari. nguva yekumirira T cell mirairo.

Panguva imwecheteyo, chirwere chakanaka chinofanirwawo kubatsira masero eT kuti arambe achifunga nezvekuonekwa kwehutachiona kuitira kuti masero eT anogona kupindura nokukurumidza uye kutungamirira muviri wose wekudzivirira zvirwere kurwisana nehutachiona zvakanyanya.Nezve chikamu ichi, EV71 yekudzivirira yakawedzerwa nePS-G ine simba kwazvo kupfuura yekudzivirira isina PS-G.Haisi kungowedzera kaviri masero emundangariro B muberere rembeva (Mufananidzo 3) asi zvakare inosimudzira spleen uye intestinal lymphatic tissue kuti ibudise mamwe anti-viral T masero uye ane hukama cytokines-interferon (IFN-γ) uye interleukin 17 (IL- 17) painorwa ruoko neruoko neutachiona.

Kuti tinzwisise zvirinani kudzivirira kwejekiseni, vaongorori vakaita ongororo mbiri dzemhuka.Imwe yezviedzo yaive yekubaya serum yemakonzo akabaiwa uye EV71 mumakonzo madiki aine B akaremara maseru kuti atariswe kwemazuva makumi maviri.Iko kushomeka kwembeva diki kwaive nehutachiona, ndiko kushanda kwakanyanya kwemasoja ekudzivirira ekudzivirira chirwere.

Zvakaonekwa kuti zvisinei nekuti mbeva dzechidiki dzakagamuchira serum kubva ku "EV-A71" Boka kana "EV-A71 + PS-G" Boka, zviratidzo zvakaita sekuremara kwemakumbo zvinogona kudzivirirwa.Nekudaro, mbeva diki dzakagamuchira serum kubva ku "EV-A71 + PS-G" Boka raive nehutachiona hushoma mukati metsinga dzetsinga, uye huwandu hwevanhu vanofa hwakaderera, zvinoreva kuti masoja ekudzivirira chirwere akawedzerwa. ne PS-G vane unyanzvi huri nani hwekudzivisa kubereka kwehutachiona uye kupa kudzivirirwa kwepamusoro (Mufananidzo 4, Mufananidzo 5).

Mune kumwe kuedza kwemhuka, vaongorori vakashandisa mbeva diki dzine mabasa ekudzivirira ekudzivirira muviri asi nyore kutapukirwa neEV71.Idzi mbeva diki dzakagamuchira chipimo chekudzivirira pa7th uye 14th mazuva mushure mekuzvarwa.Vatsvagiri vakabva vatumira EV71 mumatumbu embeva idzi diki kuburikidza nemuromo wembeva idzi diki kuti dzikonzerese kutapukira pazuva rechimakumi maviri nerimwe kuti vaone mashandiro ejekiseni pakuita kuti mbeva diki dzivirirwe nemuviri.

Mushure memavhiki maviri, huwandu hwekupona kwembeva diki dzakabaiwa ne "PS-G + vaccine" hwaive 89%, uye mwero wekupona kwemakonzo madiki akabaiwa ne "jekiseni" yaive 56%, uye hutano hwese hwekare hwakanga huri nani kupfuura. iyo yekupedzisira (Mufananidzo 6), PS-G zviri pachena kuti ine kukosha kusingakoshi mukusimudzira kushanda kwekudzivirira kwemishonga.

Basa revaccine adjuvants nderekutanga mhinduro yekudzivirira muviri, zvichiita kuti immune system inyatso ziva maantigen (senge mavhairasi) mujekiseni uye kuburitsa zvirinani kudzivirira asi chengetedzo chiricho chikuru chinodiwa pakusarudza adjuvant.Kubva pane zvawanikwa pamusoro petsvagiridzo, zvinogona kuoneka kuti iyo PS-G inogona kupeta kaviri yekutanga immune mhedzisiro yevaccine, iyo inopa yakakosha ratidziro yekuvandudza kushanda kwekudzivirira kwejekiseni.

Iyo inoshanda polysaccharide kubva kune fruiting muviri weGanoderma lucidumzvakaratidzwa munguva yakapfuura kuvandudza kuzivikanwa uye kubviswa kwevapambi nemasoja edziviriro kuburikidza ne macrophages, dendritic masero, T masero, B masero ... Ichi ndicho chikonzero inoshanda zvakanaka seanodzivirira vaccine adjuvant.Hatina mukana wekusangana nejekiseni rine PS-G, asi tisati tajoinwa, tichishandisaGanoderma lucidumkuwedzera kusadzivirirwa kwemuviri chinhu chatinogona kusarudza nekuita.

[Data Kwakabva]

Yu-Li Lin, nevamwe.Polysaccharide Yakacheneswa Kubva kuGanoderma lucidum Inoshanda seIne Simba Mucosal Adjuvant Inosimudzira Dziviriro Dziviriro Kurwisa Kunouraya Dambudziko NeEnterovirus A71.Front Immunol.2020,11:561758.doi: 10.3389/fimmu.2020.561758.

END

Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo

kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB ★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb ★ Kana mabasa acho akatenderwa kushandiswa, iwo inofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb ★ Kutyorwa kwechirevo chiri pamusoro, GanoHerb ichaita mabasa ayo ane chekuita nemutemo ★ Zvinyorwa zvepakutanga zvechinyorwa ichi chakanyorwa muchiChinese naWu Tingyao uye chakashandurirwa muchiChirungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.