Wu Tingyao

Pamene maganizo a anthu onse amasinthasintha ndi “COVID 19 katemera” ndi “COVID 19mliri”, matenda a manja ndi phazi, omwe amapezeka mwa ana osakwana zaka 5, alowanso nthawi ya mliri.Zizindikiro zake nthawi zambiri zimaphatikizapo kutentha thupi, zilonda zamkamwa, ndi zotupa pakhungu zomwe zimapezeka m'manja, mkamwa, ndi/kapena mapazi.Matendawa amayamba chifukwa cha matenda a enterovirus.

Pali mitundu yambiri ya ma enteroviruses, ambiri omwe ndi ofatsa ndipo amatha kuchotsedwa ndi chitetezo cha mthupi mkati mwa sabata.Matenda ena a enterovirus amatha kukhala ovuta kwambiri, omwe amachititsa mavuto aakulu a ubongo monga meningitis, myelitis, kufooka kwakukulu kwa flaccid, ngakhale imfa.

Enterovirus A71, yotchedwa EV-A71, ndi mtundu uwu wa zoipa zomwe ziyenera kutetezedwa mosamala.Monga momwe katemera wa COVID-19 amafunikira kuti apewe coronavirus yatsopano, katemera mosakayikira ndiye njira yabwino kwambiri yopewera matenda a EV-A71.

Komabe, monga aliyense akudziwa, palibe katemera yemwe amagwira ntchito 100%.Momwe mungasinthire mphamvu ya katemera?

Kafukufuku wofalitsidwa mu Frontiers in Immunology, magazini yovomerezeka ya International Union of Immunological Societies mu Seputembara 2020 ndi Graduate Institute of Immunology, National Taiwan University College of Medicine, ndi dipatimenti ya Medical Research, National Taiwan University Hospital idatsimikiza kuti:

Katemera wa EV-A71 wowonjezeredwa ndiGanoderma lucidumma polysaccharides amatha kulimbikitsa kupanga ma antibodies, kuyambitsa chitetezo chamthupi chokhudzana ndi kachilomboka, kupondereza kuchuluka kwa ma virus mu nyama, kuteteza kudwala kwambiri (kuukira kwapakati pamanjenje kumayambitsa kufa ziwalo) ndikuchepetsa chiopsezo cha kufa. .

Katemera wa EV-A71 womwe wagwiritsidwa ntchito poyesera ndi katemera wosagwiritsidwa ntchito wopangidwa ndi kachilombo koyambitsa matenda (akufa).Mosiyana ndi jakisoni wanthawi zonse, katemerayu amapangidwa ngati madontho a m'mphuno, omwe amatsitsidwa mwachindunji m'mphuno ndi kulowetsedwa kudzera mu mucous nembanemba kuti apangitse ma antibodies.

Koma zaGanoderma lucidumpolysaccharide yowonjezeredwa ku katemera ngati chothandizira "kuwonjezera chitetezo chamthupi chochokera ku katemera", chimachokera ku madzi otentha a matupi a zipatso a Ganoderma lucidum, omwe amatchedwa PS-G (polysaccharide yoyeretsedwa kuchokera kuGanoderma lucidum) mu kafukufukuyu.

Poyesa nyama, mbewa zathanzi zidathiridwa katemera wa 12 μL kuchokera m'mphuno zawo.Makoswe anagawidwa m'magulu atatu malinga ndi kusiyana kwa katemera:

◆ Gulu la RD lysate (No Vaccine Group): katemera wa placebo ali ndi katemera, yemwe angatengedwe ngati woimira palibe katemera;

◆ EV-A71 Gulu (Katemera Gulu): katemera ali ndi 2.5 μg ya EV-A71 yosagwiritsidwa ntchito;

◆ Gulu la EV-A71+PS-G: Katemera wa katemerayu ali ndi 2.5 μg wa EV-A71 wosatulutsidwa komanso 20 μg polysaccharide woyeretsedwa kuchokera kuGanoderma lucidum(PS-G).

Patatha milungu iwiri mbewa zitamaliza katemerayu, kuchuluka kwa ma antibodies kwa nthawi yayitali motsutsana ndi EV71 mu mbewa kunayesedwa ─- kuphatikiza IgG yomwe imapezeka makamaka mu seramu ndi madzi amthupi, ndi IgA yomwe ili yachiwiri mu seramu. ndipo makamaka amakhala mucosal minofu (oral mucosa, nasal mucosa, kupuma mucosa, ndi matumbo mucosa).Zinapezeka kuti poyerekeza ndi katemera wosavuta, katemera wophatikizidwa ndi PS-G akhoza kulimbikitsa kupanga ma antibodies enieni a IgG ndi IgA (Chithunzi 1), ndipo ma antibodies awa ali ndi zotsatira zabwino za neutralization pamitundu yosiyanasiyana ya chibadwa cha EV71 subtype, ndi amakhalanso ndi mphamvu yoletsa kwambiri ma cell omwe ali ndi kachilomboka (Chithunzi 2).

Katemera wabwino sayenera kungopangitsa kuti azitha kupanga ma antibodies abwino komanso kulimbikitsa kupanga "ma cell a memory B" kuti kachilomboka kakalowa, ayambe kutulutsa ma antibodies kuti awonjezere ankhondo atsopano pamzere wakutsogolo osawononga ndalama. nthawi yodikira malangizo a T cell.

Panthawi imodzimodziyo, katemera wabwino ayeneranso kuthandiza maselo a T kukumbukira maonekedwe a kachilomboka kuti maselo a T amatha kuyankha mofulumira ndikutsogolera magulu onse a chitetezo cha mthupi kuti amenyane ndi kachilomboka bwino.Ponena za gawoli, katemera wa EV71 wowonjezeredwa ndi PS-G ndi wamphamvu kwambiri kuposa katemera wopanda PS-G.Sikuti amangowonjezera ma cell a kukumbukira B mu ndulu ya mbewa (Chithunzi 3) komanso amalimbikitsa ndulu ndi matumbo am'mimba minofu yotulutsa ma cell a anti-viral T ndi ma cytokines-interferon (IFN-γ) ndi interleukin 17 (IL- 17) pamene ikulimbana ndi dzanja ndi kachilomboka.

Pofuna kumvetsetsa bwino chitetezo cha katemera, ofufuzawo adayesa nyama ziwiri.Chimodzi mwazoyeserera chinali kubaya seramu ya mbewa katemera ndi EV71 mu mbewa zazing'ono zomwe zili ndi ma cell a B omwe ali ndi vuto kuti awonedwe kwa masiku 20.Pamene mbewa zazing'ono zimavutitsidwa ndi kachilomboka, m'pamenenso ma antibodies opangidwa ndi katemera amakhala ogwira mtima kwambiri.

Zinapezeka kuti ziribe kanthu kaya mbewa zazing'ono zimalandira seramu kuchokera ku "EV-A71" Gulu kapena "EV-A71 + PS-G" Gulu, zizindikiro monga kufooka kwa miyendo zikhoza kupewedwa.Komabe, mbewa zazing'ono zomwe zidalandira seramu kuchokera ku Gulu la "EV-A71 + PS-G" zinali ndi kachilombo kakang'ono m'kati mwa mitsempha yapakati, ndipo chiwerengero cha imfa ndi chochepa, zomwe zikutanthauza kuti ma antibodies oyambitsidwa ndi katemera anawonjezera. ndi PS-G ali ndi luso loletsa kubereka kwa ma virus ndikupereka chitetezo chapamwamba (Chithunzi 4, Chithunzi 5).

Pakuyesa kwina kwa nyama, ofufuzawo adagwiritsa ntchito mbewa zazing'ono zomwe zimakhala ndi chitetezo chamthupi koma zimatengera EV71 mosavuta.Makoswe aang'onowa adalandira mlingo wa katemera pa masiku 7 ndi 14 atabadwa.Ofufuzawo adatumiza EV71 m'mimba mwa mbewa zazing'onozi kudzera m'kamwa mwa mbewa zazing'onozi kuti zipangitse matenda pa tsiku la 21 kuti muwone momwe katemerayu amakhudzira chitetezo cha mbewa.

Patatha milungu iwiri, kupulumuka kwa mbewa zazing'ono zomwe zidatemera katemera wa "PS-G +" zinali 89%, ndipo kupulumuka kwa mbewa zazing'ono zotemera "katemera" kunali 56%, ndipo thanzi lakale linali labwino kwambiri kuposa chakumapeto (Chithunzi 6), PS-G mwachiwonekere ili ndi tanthauzo losavomerezeka pakulimbikitsa chitetezo champhamvu cha katemera.

Udindo wa othandizira katemera ndikuyambitsa kuyankha kwa chitetezo chamthupi, zomwe zimapangitsa kuti chitetezo cha mthupi chizindikire molondola ma antigen (monga ma virus) omwe ali mu katemera ndikupanga chitetezo chokwanira pomwe chitetezo ndichofunikira kwambiri posankha chothandizira.Kuchokera pazotsatira za kafukufukuyu, zikuwoneka kuti PS-G imatha kuwirikiza kawiri mphamvu ya chitetezo chamthupi ya katemera, zomwe zimapereka chidziwitso chofunikira chamomwe mungapititsire chitetezo cha katemera.

The yogwira polysaccharide ku fruiting thupi laGanoderma lucidumzatsimikiziridwa m'mbuyomu kuti zitheke kuzindikira ndi kuthetsa oukira ndi chitetezo cha mthupi kudzera mu macrophages, maselo a dendritic, T maselo, B maselo ... Ichi ndi chifukwa chake zimagwira ntchito bwino ngati katemera wothandizira.Sitingathe kukumana ndi katemera wokhala ndi PS-G, koma musanatenge katemera, pogwiritsa ntchitoGanoderma lucidumkulimbikitsa chitetezo chamthupi ndichinthu chomwe tingasankhe ndikuchichita.

[Magwero a Data]

Yu-Lin, et al.Polysaccharide Yoyeretsedwa Kuchokera ku Ganoderma lucidum Imagwira Ntchito Ngati Mucosal Adjuvant Yamphamvu Yomwe Imalimbikitsa Chitetezo Cholimbana ndi Vuto Lakupha Ndi Enterovirus A71.Front Immunol.2020, 11:561758.doi: 10.3389/fimmu.2020.561758.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri

kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB ★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb ★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, iwo ziyenera kugwiritsidwa ntchito mkati mwa chilolezo ndikuwonetsa gwero: GanoHerb ★ Kuphwanya mawu omwe ali pamwambawa, GanoHerb idzakwaniritsa udindo wake wokhudzana ndi malamulo ★ Zolemba zoyambirira za nkhaniyi zinalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa ku Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.