Wu Tingyao

Raws li lub siab xav ntawm tag nrho noob neej hloov pauv nrog "COVID 19 tshuaj tiv thaiv"thiab"COVID 19kab mob kis thoob qhov txhia chaw”, kab mob ntawm tes-ko taw thiab qhov ncauj, tshwm sim hauv cov menyuam yaus hnub nyoog qis dua 5 xyoos, kuj tau nkag mus rau lub sijhawm muaj kev sib kis loj.Nws cov tsos mob feem ntau muaj xws li kub taub hau, mob qhov ncauj, thiab cov pob khaus ntawm daim tawv nqaij feem ntau pom ntawm tes, qhov ncauj, thiab / lossis ko taw.Tus kab mob no tshwm sim los ntawm tus kab mob enterovirus.

Muaj ntau hom kab mob enteroviruses, feem ntau yog mob me thiab tuaj yeem tshem tawm los ntawm lub cev tiv thaiv kab mob hauv ib lub lis piam. Qee cov kab mob enteroviruses tuaj yeem ua rau mob hnyav heev, ua rau mob hnyav xws li mob meningitis, myelitis, mob hlab ntsha tawg, thiab txawm tuag.

Enterovirus A71, hu ua EV-A71, yog hom kev phem no uas yuav tsum tau ua tib zoo saib xyuas.Ib yam li qhov yuav tsum tau txhaj tshuaj tiv thaiv COVID-19 los tiv thaiv tus kabmob tshiab, kev txhaj tshuaj tiv thaiv yog qhov zoo tshaj plaws los tiv thaiv tus kabmob EV-A71.

Txawm li cas los xij, raws li txhua tus paub, tsis muaj tshuaj tiv thaiv 100% zoo.Yuav ua li cas txhawm rau txhim kho kev siv tshuaj tiv thaiv?

Cov kev tshawb fawb luam tawm nyob rau hauv Frontiers in Immunology, cov ntawv xov xwm tshaj tawm ntawm International Union of Immunological Societies nyob rau lub Cuaj Hli 2020 los ntawm Graduate Institute of Immunology, National Taiwan University College of Medicine, thiab Department of Medical Research, National Taiwan University Hospital tau lees paub tias:

Cov tshuaj tiv thaiv EV-A71 ntxiv nrogGanoderma lucidumpolysaccharides tuaj yeem txhawb kev tsim cov tshuaj tiv thaiv kab mob, txhawb cov kab mob tiv thaiv kab mob tiv thaiv kab mob, tiv thaiv tus kab mob hauv cov tsiaj, tiv thaiv qhov tshwm sim ntawm kev mob hnyav (kev cuam tshuam ntawm lub hauv nruab nrab paj hlwb ua rau mob tuag tes tuag taw) thiab txo txoj kev pheej hmoo ntawm kev tuag. .

Cov tshuaj tiv thaiv EV-A71 uas siv rau hauv qhov kev sim yog ib qho tshuaj tiv thaiv tsis tau ua los ntawm tus kab mob inactivated (tuag).Sib txawv ntawm kev txhaj tshuaj ib txwm muaj, cov tshuaj tiv thaiv no yog tsim los ua qhov ntswg te, uas tau ncaj qha mus rau hauv lub qhov ntswg thiab nqus los ntawm cov mucous daim nyias nyias los ua kom muaj cov tshuaj tiv thaiv kab mob.

Raws li rau lubGanoderma lucidumpolysaccharide ntxiv rau cov tshuaj tiv thaiv ua ib qho ntxiv rau "txhim kho cov tshuaj tiv thaiv kab mob tiv thaiv kab mob", nws yog muab los ntawm cov dej kub ntawm Ganoderma lucidum fruiting lub cev, uas yog hu ua PS-G (polysaccharide purified los ntawmGanoderma lucidum) hauv kev tshawb fawb no.

Hauv kev sim tsiaj, cov nas noj qab haus huv tau txhaj tshuaj tiv thaiv 12 μL los ntawm lawv lub qhov ntswg.Cov nas tau muab faib ua peb pawg raws li qhov sib txawv ntawm kev txhaj tshuaj:

◆ RD lysate Group (No Vaccine Group): cov tshuaj tiv thaiv placebo tau txhaj tshuaj tiv thaiv, uas tuaj yeem suav tau tias yog tus neeg sawv cev tsis muaj tshuaj tiv thaiv;

◆ EV-A71 Pawg (Cov Tshuaj Tiv Thaiv): cov tshuaj tiv thaiv kab mob muaj 2.5 μg ntawm inactivated EV-A71;

◆ EV-A71+PS-G Pawg: cov tshuaj tiv thaiv muaj 2.5 μg ntawm inactivated EV-A71 ntxiv rau 20 μg polysaccharide purified los ntawmGanoderma lucidum(PS-G).

Ob lub lis piam tom qab cov nas ua tiav peb koob tshuaj tiv thaiv, qib ntawm cov tshuaj tiv thaiv ntev ntev tiv thaiv EV71 hauv cov nas tau sim ─- suav nrog IgG uas feem ntau muaj nyob hauv cov ntshav thiab cov kua hauv lub cev, thiab IgA uas yog thib ob hauv cov ntsiab lus hauv cov ntshav. thiab feem ntau nyob hauv cov ntaub so ntswg mucosa (qhov ncauj mucosa, qhov ntswg mucosa, ua pa mucosa, thiab plab hnyuv mucosa).Nws tau pom tias piv nrog cov tshuaj tiv thaiv yooj yim, cov tshuaj tiv thaiv ntxiv nrog PS-G tuaj yeem txhawb kev tsim cov tshuaj tiv thaiv IgG thiab IgA ntau dua (Daim duab 1), thiab cov tshuaj tiv thaiv no muaj kev cuam tshuam zoo rau ntau yam kab mob sib txawv ntawm EV71 subtype, thiab kuj muaj zog inhibitory nyhuv ntawm cov kab mob uas muaj kab mob (Daim duab 2).

Cov tshuaj tiv thaiv zoo yuav tsum muaj peev xwm tsis tsuas yog ua kom muaj cov tshuaj tiv thaiv zoo xwb tab sis kuj tseem ua rau tsim cov "nco B hlwb" kom sai li sai tau thaum tus kab mob nkag mus, nws tuaj yeem pib zais cov tshuaj tiv thaiv los ntxiv cov tub rog tshiab rau pem hauv ntej yam tsis tau siv nyiaj. sij hawm tos T cell cov lus qhia.

Nyob rau tib lub sijhawm, cov tshuaj tiv thaiv zoo yuav tsum pab T hlwb kom nco ntsoov cov tsos mob ntawm tus kab mob kom cov T hlwb tuaj yeem teb tau sai thiab ua rau tag nrho lub cev tiv thaiv kab mob los tua tus kab mob zoo dua.Hais txog qhov no, cov tshuaj tiv thaiv EV71 ntxiv nrog PS-G yog qhov muaj zog dua li cov tshuaj tiv thaiv tsis muaj PS-G.Nws tsis tsuas yog muab ob npaug rau lub cim xeeb B hlwb hauv tus po ntawm cov nas (Daim duab 3) tab sis kuj txhawb cov nqaij mos thiab plab hnyuv lymphatic kom zais ntau cov tshuaj tiv thaiv kab mob T hlwb thiab lwm yam cytokines-interferon (IFN-γ) thiab interleukin 17 (IL- 17) thaum nws sib ntaus sib tua tes nrog tus kab mob.

Yuav kom nkag siab zoo dua qhov kev tiv thaiv ntawm cov tshuaj tiv thaiv, cov kws tshawb fawb tau ua ob qho kev sim tsiaj.Ib qho kev sim yog txhaj cov tshuaj tiv thaiv kab mob rau nas thiab EV71 rau hauv cov nas hluas uas muaj cov kab mob B tsis zoo rau kev soj ntsuam rau 20 hnub.Qhov kev sib tw tsawg dua cov nas me yog los ntawm tus kab mob, qhov ua tau zoo dua cov tshuaj tiv thaiv kab mob tiv thaiv kab mob.

Nws tau pom tias txawm tias txawm tias cov nas me tau txais cov ntshav los ntawm "EV-A71" Pawg lossis "EV-A71 + PS-G" Pawg, cov tsos mob xws li kev tuag tes tuag taw tuaj yeem zam tau.Txawm li cas los xij, cov nas me uas tau txais cov ntshav qab zib los ntawm "EV-A71 + PS-G" Pawg muaj tus kab mob tsawg dua nyob rau hauv nruab nrab lub paj hlwb, thiab cov neeg tuag kuj qis dua, uas txhais tau hais tias cov tshuaj tiv thaiv uas tau txhaj tshuaj tiv thaiv ntxiv. nrog PS-G muaj peev xwm zoo dua los tiv thaiv kab mob rov ua dua thiab muab kev tiv thaiv ntau dua (Daim duab 4, Daim duab 5).

Hauv lwm qhov kev sim tsiaj, cov kws tshawb fawb tau siv cov nas me uas muaj lub cev tiv thaiv kab mob tab sis yooj yim kis EV71.Cov nas me no tau txhaj koob tshuaj tiv thaiv rau hnub 7 thiab 14 tom qab yug me nyuam.Cov kws tshawb fawb tau xa EV71 mus rau hauv lub plab ntawm cov nas hluas no los ntawm cov kab noj hniav ntawm cov nas me no los ua kom muaj kab mob rau hnub 21 txhawm rau soj ntsuam cov txiaj ntsig ntawm cov tshuaj tiv thaiv uas ua rau cov nas hluas lub cev tiv thaiv kab mob.

Tom qab ob lub lis piam, qhov muaj sia nyob ntawm cov nas me uas tau txhaj tshuaj "PS-G + tshuaj tiv thaiv" yog 89%, thiab qhov ciaj sia ntawm cov nas hluas uas tau txhaj tshuaj "tiv thaiv" yog 56%, thiab tag nrho kev noj qab haus huv ntawm yav dhau los tau zoo dua. uas tom kawg (Daim duab 6), PS-G pom tseeb tias muaj qhov tsis tseem ceeb hauv kev txhim kho kev tiv thaiv kev tiv thaiv ntawm cov tshuaj tiv thaiv.

Lub luag haujlwm ntawm cov tshuaj tiv thaiv adjuvants yog los pib lub cev tiv thaiv kab mob, ua rau lub cev tiv thaiv kab mob kom raug txheeb xyuas cov antigens (xws li cov kab mob) hauv cov tshuaj tiv thaiv thiab tsim kom muaj kev tiv thaiv zoo dua thaum kev nyab xeeb yog qhov tseem ceeb tshaj plaws rau kev xaiv ib qho adjuvant.Los ntawm cov txiaj ntsig kev tshawb fawb saum toj no, nws tuaj yeem pom tias PS-G tuaj yeem ua ob npaug ntawm cov tshuaj tiv thaiv kab mob qub, uas muab cov ntaub ntawv muaj txiaj ntsig zoo rau kev txhim kho kev tiv thaiv zoo ntawm cov tshuaj tiv thaiv.

Lub active polysaccharide los ntawm fruiting lub cev ntawmGanoderma lucidumtau raug pov thawj yav dhau los los txhim kho kev txheeb xyuas thiab tshem tawm cov neeg tawm tsam los ntawm kev tiv thaiv kab mob los ntawm macrophages, dendritic cells, T cells, B cells… Qhov no yog vim li cas nws ua haujlwm zoo li tshuaj tiv thaiv adjuvant.Peb tsis zoo li yuav ntsib cov tshuaj tiv thaiv uas muaj PS-G, tab sis ua ntej txhaj tshuaj tiv thaiv, sivGanoderma lucidumtxhawm rau txhawb kev tiv thaiv yog ib yam uas peb tuaj yeem txiav txim siab thiab ua.

[Cov ntaub ntawv Source]

Yu-Li Lin, et al.Lub Polysaccharide Purified Los ntawm Ganoderma lucidum Ua raws li lub peev xwm Mucosal Adjuvant uas txhawb nqa kev tiv thaiv kev tiv thaiv kev sib tw tuag nrog Enterovirus A71.Pem hauv ntej Immunol.Xyoo 2020, 11:561758.doi: 10.3389/fimmu.2020.561758.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv

txij li xyoo 1999. Nws yog tus sauKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB ★ Cov haujlwm saum toj no tsis tuaj yeem luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb ★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv lub Scope ntawm kev tso cai thiab qhia lub hauv paus: GanoHerb ★ Kev ua txhaum ntawm cov lus saum toj no, GanoHerb yuav caum nws cov luag hauj lwm raws li txoj cai ★ Thawj cov ntawv nyeem ntawm tsab xov xwm no yog sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.