Wu Tingyao

E like me ke ʻano o ke ʻano o ke kanaka holoʻokoʻa me ka "COVID-19 lāʻau lapaʻau"a"COVID-19maʻi maʻi", maʻi lima-wāwae-a-waha, maʻamau i nā keiki ma lalo o 5 mau makahiki, ua komo pū i kahi wā maʻi maʻi kiʻekiʻe.ʻO kona mau hōʻailona maʻamau ka maʻi kuni, ka ʻeha waha, a me ka ʻili ʻili i loaʻa mau ma nā lima, ka waha, a me nā wāwae.ʻO kēia maʻi ma muli o ka maʻi enterovirus.

Nui nā ʻano enterovirus, ʻo ka hapa nui o ia mau mea maʻalahi a hiki ke hoʻomaʻemaʻe ʻia e ka ʻōnaehana immune i loko o hoʻokahi pule. Hiki i kekahi mau enterovirus ke koʻikoʻi loa, e hoʻopiʻi ai i nā pilikia neurological koʻikoʻi e like me ka maningitis, myelitis, acute flaccid paralysis, a me ka make.

ʻO Enterovirus A71, i kapa ʻia ʻo EV-A71, ʻo ia kēia ʻano ʻino e pono ke kiaʻi pono ʻia.E like me ka mea e pono ai ka maʻi maʻi COVID-19 e pale i ka coronavirus novel, ʻo ka hoʻopaʻa ʻana ʻo ia ke ala maikaʻi loa e pale ai i ka maʻi EV-A71.

Eia naʻe, e like me ka ʻike a nā mea a pau, ʻaʻohe lāʻau lapaʻau i 100% maikaʻi.Pehea e hoʻomaikaʻi ai i ka maikaʻi o ka lāʻau lapaʻau?

ʻO ka noiʻi i paʻi ʻia ma Frontiers in Immunology, ka nūpepa kūhelu o ka International Union of Immunological Societies i Kepakemapa 2020 e ka Graduate Institute of Immunology, National Taiwan University College of Medicine, a me ke Keʻena ʻO ka ʻImi Kauka, National Taiwan University Hospital i hōʻoia ʻia:

Hoʻohui ʻia ke kano EV-A71 meʻO Ganoderma lucidumHiki i nā polysaccharides ke hoʻoikaika i ka hana ʻana i nā antibodies neutralizing, hoʻoulu i nā pane kūlohelohe e pili ana i ka anti-virus, kāohi i ka nui o ka maʻi i loko o nā holoholona, ​​​​pale i ka loaʻa ʻana o ka maʻi koʻikoʻi (ka hoʻouka ʻana i ka ʻōnaehana nūnū waena e hoʻoulu ai i ka maʻi maʻi flaccid maʻi) a hōʻemi i ka hopena o ka make. .

ʻO ka lāʻau lapaʻau EV-A71 i hoʻohana ʻia i ka hoʻokolohua he lāʻau lapaʻau i hana ʻia me ka maʻi maʻi ʻole (make).ʻOkoʻa mai nā injections kahiko, ua hoʻolālā ʻia kēia maʻi e like me nā hāʻule o ka ihu, i hāʻule pololei ʻia i loko o nā puka ihu a komo i loko o ka mucous membrane e hoʻoulu i ka hana ʻana o nā antibodies.

No kaʻO Ganoderma lucidumʻO ka polysaccharide i hoʻohui ʻia i ka lāʻau lapaʻau ma ke ʻano he adjuvant e "hoʻonui i ka pane ʻana o ka maʻi maʻi", ua loaʻa ia mai ka wai wela o nā kino hua hua Ganoderma lucidum, i kapa ʻia ʻo PS-G (polysaccharide i hoʻomaʻemaʻe ʻia mai.ʻO Ganoderma lucidum) ma kēia noiʻi.

I loko o nā hoʻokolohua holoholona, ​​ua hoʻomaʻamaʻa ʻia nā ʻiole olakino me 12 μL hāʻule kano mai ko lākou mau puka ihu.Ua māhele ʻia nā ʻiole i ʻekolu pūʻulu e like me ka ʻokoʻa o ka hoʻopaʻa ʻana:

◆ Pūʻulu lysate RD (ʻAʻohe Pūʻulu Vaccine): ua hoʻopaʻa ʻia ka lāʻau lapaʻau placebo, hiki ke manaʻo ʻia ʻo ia ka ʻelele no ka loaʻa ʻole;

◆ Pūʻulu EV-A71 (Puʻupuʻu Vaccine): aia ka 2.5 μg o ka EV-A71 i hoʻopaʻa ʻia;

◆ Pūʻulu EV-A71+PS-G: ʻo ka lāʻau lapaʻau i hoʻopaʻa ʻia he 2.5 μg o EV-A71 i hoʻohana ʻole ʻia me 20 μg polysaccharide i hoʻomaʻemaʻe ʻia maiʻO Ganoderma lucidum(PS-G).

ʻElua pule ma hope o ka pau ʻana o nā ʻiole ʻekolu o ka lāʻau lapaʻau, ua hoʻāʻo ʻia ke kiʻekiʻe o nā antibodies lōʻihi e kūʻē iā EV71 i loko o nā ʻiole ─- me ka IgG ka mea nui i loko o ka serum a me ka wai kino, a me ka IgA ka lua o ka maʻiʻo serum. a noho nui i loko o nā ʻiʻo mucosal (mucosa waha, mucosa nasal, mucosa hanu, a me ka mucosa intestinal).Ua ʻike ʻia i ka hoʻohālikelike ʻia me kahi kano maʻalahi, hiki i kahi kano i hoʻohui ʻia me PS-G ke hoʻoikaika i ka hana ʻana o nā antibodies IgG a me IgA kikoʻī (Figure 1), a he hopena neutralization maikaʻi kēia mau antibodies i nā ʻano ʻano genetic like ʻole o ka subtype EV71, a ʻoi aku ka ikaika o ka pale ʻana i nā maʻi maʻi (Figure 2).

ʻAʻole hiki i ka lāʻau lapaʻau maikaʻi ke hoʻoulu wale i ka hana ʻana o nā antibodies maikaʻi akā hoʻoulu pū i ka hana ʻana o nā "mea hoʻomanaʻo B cell" i ka wā e komo mai ai ka maʻi, hiki iā ia ke hoʻomaka e huna i nā antibodies e hoʻohui i nā pūʻali koa hou no ka laina mua me ka ʻole o ka hoʻolimalima. ka manawa e kali ana i nā ʻōlelo kuhikuhi T cell.

I ka manawa like, pono nō hoʻi e kōkua pū kekahi lāʻau lapaʻau maikaʻi i nā pūnaewele T e hoʻomanaʻo i ke ʻano o ka maʻi i hiki ke pane koke ʻo T cell a alakaʻi i ke kino holoʻokoʻa e hakakā i ka maʻi maʻi.E pili ana i kēia ʻāpana, ʻoi aku ka ikaika o ka kano EV71 i hoʻohui ʻia me PS-G ma mua o ke kano me ka ʻole o PS-G.ʻAʻole wale ia e pāpālua i nā pūnaewele B hoʻomanaʻo i loko o ka spleen o nā ʻiole (Figure 3) akā hoʻoikaika pū nō hoʻi i ka spleen a me ka ʻiʻo lymphatic intestinal e hūnā i nā mea anti-viral T a me nā cytokines-interferon (IFN-γ) pili a me interleukin 17 (IL- 17) ke hakakā lima me ka maʻi maʻi.

I mea e hoʻomaopopo maikaʻi ai i ka hopena pale o ke kano, ua hana nā mea noiʻi i ʻelua mau hoʻokolohua holoholona.ʻO kekahi o nā hoʻokolohua, ʻo ia ka hoʻokomo ʻana i ka serum o nā ʻiole i hoʻopaʻa ʻia a me ka EV71 i loko o nā ʻiole ʻōpio me nā ʻiole B hemahema no ka nānā ʻana no nā lā 20.ʻO ka liʻiliʻi o ka paʻakikī o nā ʻiole ʻōpio e ka maʻi, ʻoi aku ka maikaʻi o nā antibodies i hoʻokomo ʻia i ke kano.

Ua ʻike ʻia ʻaʻole i loaʻa i nā ʻiole ʻōpio ka serum mai ka hui "EV-A71" a i ʻole ka hui "EV-A71 + PS-G", hiki ke pale ʻia nā hōʻailona e like me ka maʻi lolo.Eia nō naʻe, ʻo nā ʻiole ʻōpio i loaʻa i ka serum mai ka hui "EV-A71 + PS-G" he liʻiliʻi ka nui o ka maʻi i loko o ka ʻōnaehana nūnū waena, a ʻoi aku ka haʻahaʻa o ka make, ʻo ia hoʻi ua hoʻohui ʻia nā antibodies i hoʻokomo ʻia e ke kano. me ka PS-G i oi aku ka hiki ke keakea i ka hana hou a me ka hoomalu ana i ke kiekie (Kii 4, Kii 5).

Ma kahi hoʻokolohua holoholona ʻē aʻe, ua hoʻohana nā mea noiʻi i nā ʻiole ʻōpio me nā hana kūlohelohe maʻamau akā maʻalahi ka maʻi me EV71.Ua loaʻa i kēia mau ʻiole ʻōpio kahi maʻi o ka lāʻau lapaʻau ma ka lā 7 a me 14 ma hope o ka hānau ʻana.A laila hoʻouna ka poʻe noiʻi i ka EV71 i loko o ka ʻōpū o kēia mau ʻiole ʻōpio ma o ka waha waha o kēia mau ʻiole ʻōpio e hoʻoulu i ka maʻi ma ka lā 21 e nānā i ka hopena o ka lāʻau lapaʻau i ka hoʻoulu ʻana i ka pane kūlohelohe o nā ʻiole ʻōpio.

Ma hope o ʻelua pule, ʻo ka nui o ke ola o nā ʻiole ʻōpio i hoʻopaʻa ʻia me ka "PS-G + vaccine" he 89%, a ʻo ka nui o ke ola o nā ʻiole ʻōpio i hoʻopaʻa ʻia me ka "vaccine" he 56%, a ʻoi aku ka maikaʻi o ke olakino holoʻokoʻa o ka mua ma mua o ʻelua pule. ʻo ia o ka hope (Figure 6), maopopo ʻole he koʻikoʻi ko PS-G i ka hoʻonui ʻana i ka pono pale o nā lāʻau lapaʻau.

ʻO ke kuleana o nā adjuvants kano ka hoʻomaka ʻana i kahi pane kūlohelohe, e koi ana i ka ʻōnaehana pale e hoʻomaopopo pololei i nā antigens (e like me nā maʻi) i loko o ke kano a hoʻopuka i ka pono palekana ʻoi aku ka maikaʻi ʻoiai ʻo ka palekana ka mea nui loa no ke koho ʻana i kahi adjuvant.Mai nā hualoaʻa noiʻi ma luna, hiki ke ʻike ʻia hiki i ka PS-G ke pālua i ka hopena kūlohelohe mua o ka maʻi maʻi, e hāʻawi ana i kahi kuhikuhi waiwai no ka hoʻomaikaʻi ʻana i ka pono pale o ka maʻi.

ʻO ka polysaccharide ikaika mai ke kino hua oʻO Ganoderma lucidumua hōʻoia ʻia i ka wā ma mua e hoʻomaikaʻi i ka ʻike a me ka hoʻopau ʻana i nā mea hoʻouka kaua e ka ʻōnaehana immune ma o macrophages, dendritic cell, T cell, B cell… ʻO ia ke kumu e hana maikaʻi ai ia ma ke ʻano he adjuvant kano.ʻAʻole paha mākou e hālāwai me kahi kano i loaʻa ka PS-G, akā ma mua o ka hoʻohana ʻanaʻO Ganoderma lucidumʻo ka hoʻoikaika ʻana i ka palekana he mea hiki iā mākou ke hoʻoholo a hana.

[Kumu ʻikepili]

Yu-Li Lin, et al.ʻO kahi Polysaccharide i hoʻomaʻemaʻe ʻia mai ka Ganoderma lucidum e hana ma ke ʻano he Adjuvant Mucosal Potent e hoʻolalelale ai i ka pale palekana e kūʻē i ka hoʻokūkū make me Enterovirus A71.Imunol mua.2020,11:561758.doi: 10.3389/fimmu.2020.561758.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike

mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka GanoHerb ★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, Pono e hoʻohana ʻia i loko o ke ʻano o ka ʻae ʻia a hōʻike i ke kumu: GanoHerb ★ ʻAi ʻole i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i kāna mau kuleana pili kānāwai ★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Kina e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.