Okthoba 2017/Dicle University/Korean Journal of Neurotrauma

Umbhalo/ Wu Tingyao

Phambilini bekuzwakala ukuthi abanye balimale kabi ebuchosheni ngenxa yezingozi.Ngaphezu kokuthola ukwelashwa njalo, babuye bathatha okuningiI-Ganoderma lucidum.Ngenxa yalokho, isivinini kanye nomphumela wokubuyisela kwakungaphezu kwalokho okwakulindelwe.Ushicilelo lwama-63 (Spring 2014) lwe-"Healthy Ganoderma" olukhishwe yi-Microbiology Culture and Education Foundation luphinde lwethula amacala angempela ayisithupha okusetshenziswa.I-Ganoderma lucidumukubuyisela emuva ukuhlukumezeka okubangelwa izingozi zezimoto.

Is I-Ganoderma lucidumngakho "imilingo"?Umbiko oshicilelwe ku "Korean Journal of Neurotrauma" (South Korean Journal of Neurotrauma) yi-Dicle University eTurkey ngo-Okthoba 2017 ukuqinisekisile ngokuhlolwa kwezilwane ukuthi ukukhishwa kwe-polysaccharideI-Ganoderma lucidumimizimba ethela izithelo ingasheshisa ukululama kokulimala kobuchopho, futhi indlela yayo yokusebenza ihlobene nokunciphisa ukucindezeleka okwenziwe nge-oxidative nokunciphisa ukuvuvukala.

Abacwaningi basebenzise indlela yokwenziwa "yokuwa ukusuka phezulu" ukuze kubangele ukulimala kwengqondo kumagundane.Ingxenye yabo (amagundane angu-16) ayizange ithole ukwelashwa (iqembu lokuhlukumezeka kobuchopho).Enye ingxenye (ukuhlukumezeka kobuchopho +I-Ganoderma lucidumgroup) wondliwe ngawoI-Ganoderma lucidum ngethamo elinikeziwe lansuku zonke lama-20 ml ngekhilogremu yesisindo somzimba imizuzu engama-30 ngemuva kokuhlukumezeka (mL ngayinyeI-Ganoderma lucidumukukhishwa kwamanzi kuqukethe i-2 mg ye-polysaccharides).Ukuhlukumezeka kwengqondo kwamagundane kuhlolwa ngemva kwezinsuku eziyisikhombisa.Ukuhlola kuphinde kwasebenzisa amagundane avamile (iqembu lokulawula) kanye namagundane avamile adliswa ngawoI-Ganoderma lucidumi-polysaccharide(Ganoderma lucidumgroup) ukuqhathanisa namaqembu amabili adlule.

Ukopha ebuchosheni kungabangela ukuvuvukala, kwandise umfutho we-oxidative ebuchosheni (ama-enzyme e-antioxidant azokwehla, futhi inani lama-radicals mahhala lizokwanda), futhi kungase kubangele i-edema (ecindezela izicubu zobuchopho futhi zilimaze).Umgoqo woqobo wegazi nobuchopho (umgoqo wemvelo phakathi kwemithambo yegazi nobuchopho ongavimba izinto zangaphandle ukuthi zingangeni ebuchosheni) nazo zizobhujiswa, kubangele amangqamuzana egazi amhlophe engeziwe ukuthi angene ebuchosheni noma abangele izifo zobuchopho, okwenza ukuvuvukala kube kubi kakhulu. .

Lezi zimo azihambisani nokululama kwezicubu zobuchopho ekuhlukumezekeni.Kodwa ngokwemiphumela yokuhlolwa kwezilwane kulo mbiko, ngemva kokuba amagundane ahlukumezekile ebuchosheni eselashweI-Ganoderma lucidumi-polysaccharide izinsuku eziyisikhombisa, izicubu zabo zobuchopho zonakaliswa kancane ama-radicals mahhala (i-MDA iyanciphisa), i-enzyme ye-antioxidant ye-GSH eyenza i-neutralize radicals yamahhala ebuchosheni iyanda, ukuvuvukala kwamangqamuzana egazi amhlophe akubi kakhulu (ukukhishwa kwe-peroxidase MPO kuncane), i-cerebral i-edema nayo ithuthuke kakhulu, futhi ukungeneka komgoqo wegazi nobuchopho nakho kuseduze kokujwayelekile— wonke amanani ahluke kakhulu kulawo amagundane ahlukumezekile ebuchosheni angazange athole ukwelashwa (bona ithebula elingezansi).

Ngaphezu kwalokho, kungabonakala ezingxenyeni zezicubu ze-cerebral cortex ukuthiI-Ganoderma lucidumama-polysaccharides angathuthukisa ukunwetshwa kwemithambo yegazi kanye ne-edema, alungise amangqamuzana ezinzwa, futhi asheshise ukululama kobuchopho obulimele (njengoba kuboniswe ngezansi).I-cerebral cortex ibhekisela esakhiweni esixhumene njengesikhumba esinemibimbi eminingi esongwe ongqimbeni olungaphandle lobuchopho.Inesibopho semizwa esezingeni eliphezulu namakhono okucabanga.Ngakho-ke, ukululama kwale ndawo kubaluleke kakhulu.

Abacwaningi baphinde bahlola ezinye izinkomba ezintathu ezibalulekile ezicutshini zobuchopho begundane, kuhlanganise ne-protein kinase p38 MAPK, ehlobene kahle nokuvuvukala, i-vascular endothelial growth factor (VEGF), edingekayo ukuze kulungiswe isakhiwo se-vascular, kanye ne-microglial cell, ephethe ukususa amangqamuzana ezinzwa ezilimele kanye namagciwane.

Kwatholakala ukuthi, uma kuqhathaniswa namagundane ahlukumezekile ebuchosheni ayengadliI-Ganoderma lucidumama-polysaccharides, nakuba umsebenzi we-p38 MAPK wawusatholwa kumagundane ahlukumezekile ebuchosheni adla.I-Ganoderma lucidumama-polysaccharides, (okubonisa ukuthi ukusabela kwakuqhubeka kodwa kwakulawulekile futhi kwakungeke kube kubi), izici zabo zokukhula kwe-vascular endothelial kanye namangqamuzana e-microglial anda kakhulu, okubonisa ukuthiI-Ganoderma lucidumi-polysaccharide inenzuzo ekulungiseni nasekwakheni kabusha imikhumbi yobuchopho kanye nezinzwa ze-cranial.

Imiphumela yokuhlola engenhla ibonisa umphumela wokuphatha okuqhubekayo kweI-Ganoderma lucidumama-polysaccharides izinsuku eziyisikhombisa ngemva kokulimala kobuchopho.Abacwaningi bakholelwa ukuthi uma umthamo ofanele weI-Ganoderma lucidumama-polysaccharides angasetshenziswa njenge-adjuvant therapy ngemva kokulimala kobuchopho, azosiza kakhulu ekudambiseni ukuvuvukala kanye ne-cerebral edema, noma ukuvikela amangqamuzana ezinzwa namaseli e-glial.

[Umthombo] Özevren H, et al.I-Ganoderma Lucidum ivikela izicubu zobuchopho begundane ekucindezelekeni kwe-oxidative okubangelwa ukuhlukumezeka.I-Korean J Neurotrauma.2017;13(2): 76-84.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali

★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali

★ Ukwephulwa kwesitatimende esingenhla, umbhali uzophishekela izibopho zayo ezingokomthetho ezihlobene

★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.