Ngo-Oktobha 2017 / iYunivesithi yaseDicle / iJenali yaseKorea ye-Neurotrauma

Umbhalo/ Wu Tingyao

Kwixa elidlulileyo, bekuvakala ukuba abanye abantu bonzakele ngenxa yeengozi.Ngaphandle kokufumana unyango rhoqo, nabo bathatha kakhuluI-Ganoderma lucidum.Ngenxa yoko, isantya kunye nesiphumo sokubuyisela sasingaphaya kokulindela.Umcimbi wama-63 (Spring 2014) we "Healthy Ganoderma" ekhutshwe yiMicrobiology Culture and Education Foundation nayo yazisa iimeko ezintandathu zokwenyani zokusetyenziswa.I-Ganoderma lucidumukubuyisela umva umvandedwa obangelwe ziingozi zemoto.

Is I-Ganoderma lucidumngoko "umlingo"?Ingxelo epapashwe kwi "Korean Journal of Neurotrauma" (South Korean Journal of Neurotrauma) yiDyunivesithi yaseDicle eTurkey ngo-Okthobha 2017 iqinisekise ngovavanyo lwezilwanyana ukuba isicatshulwa se-polysaccharideI-Ganoderma lucidumimizimba eneziqhamo inokukhawulezisa ukubuyiswa kokwenzakala kwengqondo, kwaye indlela yokusebenza kwayo inxulumene nokunciphisa uxinzelelo lwe-oxidative kunye nokucothisa ukudumba.

Abaphandi basebenzise indlela eyenziweyo "yokuwa ukusuka phezulu" ukwenza ukulimala kwengqondo kwiimpuku.Isiqingatha sabo (iigundane ze-16) abazange bafumane naluphi na unyango (iqela le-brain trauma).Esinye isiqingatha (ukwenzakala kwengqondo +I-Ganoderma lucidumgroup) wondliwa kunyeI-Ganoderma lucidum kumthamo onikiweyo wemihla ngemihla wama-20 mL ngekhilogram yobunzima bomzimba kwimizuzu engama-30 emva kokwenzakala (mL nganyeI-Ganoderma lucidumisicatshulwa samanzi sine-2 mg ye-polysaccharides).Ukwenzakala kwengqondo kweempuku zivandlakanywa emva kweentsuku ezisixhenxe.Uvavanyo lukwasebenzise iimpuku eziqhelekileyo (iqela lolawulo) kunye neempuku eziqhelekileyo ezityiswa ngazoI-Ganoderma lucidumi-polysaccharide(Ganoderma lucidumgroup) ukuthelekisa namaqela amabini angaphambili.

Ukopha engqondweni kunokubangela ukudumba, kwandise uxinzelelo lwe-oxidative ebuchosheni (i-antioxidant enzymes iya kuncipha, kwaye inani leeradicals zasimahla liya kwanda), kwaye kunokubangela i-edema (ecudisa izicubu zobuchopho kwaye yonakalise).Isithintelo sokuqala segazi-ingqondo (umqobo wendalo phakathi kwemithambo yegazi kunye nengqondo enokuthintela izinto zangaphandle ukuba zingene ebuchotsheni) nazo ziya kutshatyalaliswa, zibangele iiseli zegazi ezimhlophe ezingakumbi ukuba zingene ebuchotsheni okanye zibangele usulelo lobuchopho, lwenza ukudumba kube kubi ngakumbi. .

Ezi meko azikuncedi ukubuyiswa kwezicubu zobuchopho kumothuko.Kodwa ngokweziphumo zovavanyo lwezilwanyana kule ngxelo, emva kokuba iimpuku ezonzakele ebuchotsheni zinyangweI-Ganoderma lucidumi-polysaccharide iintsuku ezisixhenxe, izicubu zabo zengqondo zonakaliswa kancinane ngama-radicals amahhala (i-MDA iyanciphisa), i-enzyme ye-antioxidant ye-GSH eyenza i-neutralize radicals yamahhala kwingqondo iyanda, ukuvuvukala kweeseli ezimhlophe zegazi kuncinci kakhulu (imfihlo ye-peroxidase MPO incinci), i-cerebral I-edema nayo iphuculwe kakhulu, kwaye ukunyanzeliswa kwesithintelo segazi-ingqondo kwakhona kusondele kwisiqhelo- zonke ixabiso zihluke kakhulu kwiigundane eziphazamisekileyo zengqondo ezingakhange zifumane naluphi na unyango (jonga itafile engezantsi).

Ukongeza, kunokubonwa kumacandelo ezicubu ze-cerebral cortex ukubaI-Ganoderma lucidumI-polysaccharides inokuphucula i-blood vessel dilation kunye ne-edema, ukulungisa iiseli ze-nerve, kunye nokukhawulezisa ukubuyiswa kwengqondo eyonzakeleyo (njengoko kuboniswe ngezantsi).I-cerebral cortex ibhekisa kwisakhiwo esidityanisiweyo esifana nesikhumba esinemibimbi emininzi esongelwe kumaleko angaphandle wobuchopho.Inoxanduva lweemvakalelo ezikwinqanaba eliphezulu kunye namandla okucinga.Ngoko ke, ukuchacha kule ndawo kubaluleke kakhulu.

Abaphandi baphinde bavavanya ezinye izibonakaliso ezintathu ezibalulekileyo kwizicubu zobuchopho begundane, kuquka iprotein kinase p38 MAPK, ehambelana ngokufanelekileyo nokuvuvukala, i-vascular endothelial growth factor (VEGF), efunekayo ukulungisa isakhiwo se-vascular, kunye ne-microglial cell, ejongene nokunciphisa ukuvuvukala. ukususa iiseli ze-nerve ezonakeleyo kunye ne-pathogens.

Kwafunyaniswa ukuba, xa kuthelekiswa neempuku eziphazamisekile engqondweni ezingatyiI-Ganoderma lucidumiipolysaccharides, nangona umsebenzi we-p38 MAPK wawusafunyaniswa kwiigundane ezenzakalisa ingqondo ezityileyo.I-Ganoderma lucidumi-polysaccharides, (ebonisa ukuba impendulo yayiqhubeka kodwa yayilawulwa kwaye yayingayi kuba nzima), izinto zabo zokukhula kwe-vascular endothelial kunye neeseli ze-microglial zanda kakhulu, ezibonisa ukubaI-Ganoderma lucidumi-polysaccharide inenzuzo ekulungiseni nasekuvuseleleni iinqanawa ze-cerebral kunye ne-cranial nerves.

Iziphumo zovavanyo ezingentla zibonisa umphumo wolawulo oluqhubekayo lweI-Ganoderma lucidumiipolysaccharides iintsuku ezisixhenxe emva kokulimala kwengqondo.Abaphandi bakholelwa ukuba ukuba idosi efanelekileyoI-Ganoderma lucidumI-polysaccharides inokusetyenziswa njengonyango lwe-adjuvant emva kokwenzakala kwengqondo, iya kuba luncedo kakhulu ekunciphiseni ukudumba kunye ne-cerebral edema, okanye ukukhusela iiseli ze-nerve kunye neeseli ze-glial.

[Umthombo] Özevren H, et al.I-Ganoderma Lucidum ikhusela izicubu zobuchopho zegundane ngokuchasene noxinzelelo olubangelwa yi-oxidative.Korean J Neurotrauma.2017;13(2): 76-84.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi ukususela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali

★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali

★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olunxulumene nomthetho

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.