Ingabe i-Lingzhi inomphumela ovimbelayo ku-noveli coronavirus (SARS-CoV-2)?Ingabe ukudla i-Lingzhi ngemva kokuthola inoveli inyumoniya ye-coronary (COVID-19) kuyasiza ukucindezela inoveli coronavirus?

Besilokhu sisebenzisa umsebenzi we-“Ganoderma lucidum’s immune regulation” njengesisekelo sethiyori “se-Ganoderma lucidum’s anti-virus”.Manje, ekugcineni sekunobufakazi obuqondile bokusinika impendulo ecacile.

Umbiko oshicilelwe yithimba labacwaningi baseTaiwan e-PNAS (Proceedings of the National Academy of Sciences) ngoJanuwari 15 kulo nyaka (2021) ukuqinisekisile ukuthi i-Ganoderma lucidum polysaccharides, enye yezithako eziyinhloko ezisebenzayo ku-Ganoderma lucidum, ingavimbela ukutheleleka kwamaseli ngo. i-coronavirus yenoveli, ivimbela ukuphindaphindeka kanye nokwanda kwe-coronavirus yenoveli emangqamuzaneni, futhi yehlise inani le-coronavirus yenoveli emaphashini ngemuva kokuba izilwane zingenwe yi-coronavirus yenoveli.

Vimba ukuphindaphinda kwegciwane ngaphandle kokulimaza amaseli

Ithimba labacwaningi elishiwo ngenhla lenze izivivinyo ze-in vitro okokuqala: okokuqala, amaseli e-Vero E6 kanye ne-Ganoderma lucidum polysaccharide extract (igama lekhodi RF3) ahlanganiswa ndawonye, ​​kwase kwengezwa i-coronavirus yenoveli ukuze kubhekwe inani lokuphindaphinda kwegciwane kanye nokusinda kwamaseli ngemuva kwalokho. Amahora angu-48.

Njengoba sonke sazi, i-coronavirus yenoveli ihlasela umzimba womuntu ngesamukeli se-ACE2 esitokisini.Amaseli e-Vero E6 avela ezicutshini zezinso zezinkawu eziluhlaza zase-Afrika angaveza inani elikhulu lama-receptors e-ACE2, ngakho-ke lapho ehlangana ne-coronavirus yenoveli, i-coronavirus yenoveli ingangena kalula kulawa maseli ukuze iphindaphindeke futhi yande.

Imiphumela ibonisa ukuthi ukukhishwa kwe-Ganoderma lucidum polysaccharide kunganciphisa inani lokuphindaphinda kwegciwane libe uhhafu ekuhlanganiseni okuphansi kuka-2 μg/mL ngaphandle kokubangela ukufa kwamaseli (bona isithombe nombhalo othathwe embikweni wocwaningo ngezansi ukuze uthole imininingwane).

Umthombo/PNAS Febhruwari 2,2021 118(5) e2021579118

Yehlisa inani legciwane emaphashini ama-hamster

Isinyathelo esilandelayo kwaba ukuhlolwa kwezilwane: ama-hamster aqala ukungenwa i-coronavirus yenoveli, kwase kuthi i-Ganoderma lucidum polysaccharide extract yanikezwa lawa ma-hamster ngomlomo ngethamo lansuku zonke lama-200 mg/kg izinsuku ezintathu.

Kutholakale ukuthi inani legciwane emaphashini ama-hamster lalingaba yisigamu kuphela seqembu lokulawula (ngaphandle kwezidakamizwa) (njengoba kuboniswe esithombeni esingezansi), futhi isisindo sama-hamster asizange sehle kakhulu.Lokhu kusho ukuthi ukukhishwa kwe-Ganoderma lucidum polysaccharide akukwazi nje ukuvimbela ngempumelelo ukwanda kwe-coronavirus yenoveli kodwa futhi kuphephe kakhulu ukudliwa.

Umthombo/PNAS Februwari 2, 2021 118(5)e2021579118

Umthombo/PNAS Febhruwari 2,2021 118(5)e2021579118

Ungayithathi kancane imiphumela yokuhlolwa kwe-“hamster”.Izicubu zokuphefumula ze-hamster zifana nezabantu.Lapho amasosha omzimba ekhuthazwa ukutheleleka, izicubu zokuphefumula zama-hamster nazo zinama-cytokines avuthayo afana nabantu.Ngakho-ke, imiphumela ye-Reishi mushroom polysaccharide extract kanye ne-coronavirus yenoveli elwa yodwa kuma-hamster inenani elikhulu lokubhekisela.

Ama-polysaccharides e-Reishi agqama emithini nasezikhishweni ezingaphezu kuka-3,000

Ukuhlola okungenhla kusibonise ukuthi i-Ganoderma lucidum polysaccharides ingavikela amaseli futhi ilwe nokutheleleka kwe-coronavirus yenoveli - okungenani uma ithathwa ngaphambi kokutheleleka noma ngesikhathi sokuqala sokutheleleka, i-Ganoderma lucidum polysaccharides inomphumela omuhle kakhulu we-antiviral.

Akulula ngempela ukuthi i-Ganoderma lucidum polysaccharides ingagqama kulolu cwaningo.

Ithimba labacwaningi liqale laqoqa imithi yabantu noma yezilwane engu-2,855 egunyazwe yi-US Food and Drug Administration (FDA).Okwesibili, ithimba lakhetha izinto zokwelapha ezicishe zibe ngu-200 ezinemiphumela yokwelapha ezifweni ezibangelwa amagciwane kusukela kwezakudala zomuthi wendabuko waseShayina.Okulandelayo, ithimba lahlola izidakamizwa eziyi-15 noma izithako ezinamandla okulwa nokutheleleka ngegciwane ekuhlolweni kwamaseli okwenziwa elabhorethri ye-P3.

Ithimba libe seliwinela imithi eyi-7 ephezulu noma izithako ekuhloleni izilwane ukuze kuhambisane nezinhlobo zegciwane.Ekugcineni, zimbili kuphela izinhlobo zemithi (umuthi olwa nomalaleveva obizwa ngokuthi i-mefloquine kanye nomuthi wokulwa nengculazi okuthiwa i-neflinavir) kanye nezinhlobo ezi-3 zemithi yamakhambi nezithako zamakhambi (Reishi mushroom polysaccharides, Perilla frutescens kanye ne-Mentha haplocalyx) ezingasebenzisa ngempela i-antiviral. imiphumela emzimbeni.

Phakathi kwalezi zithako ezinhlanu, i-Ganoderma lucidum polysaccharides kuphela engasebenza ngempumelelo ngokumelene namagciwane ngaphandle kokubangela ukufa kwamangqamuzana, ukuncipha kwesisindo noma ukuphazamisa imisebenzi yomzimba.

Ngaphezu kwalokho, ama-polysaccharides angenye yezithako ezisebenzayo ku-Ganoderma lucidum.Uma singangeza ama-triterpenes noma sisebenzise yonke i-Ganoderma lucidum ukulwa negciwane, kuzokwenzekani?

Imithi yokugoma ingavikela ingxenye eyodwa kuphela yomzimba wethu, kodwa yini okufanele isetshenziselwe ukuvikela ingxenye leyo imigomo engeke iyivikele?

Masidle amakhowe kaReishi ngaphezulu!

Futhi kufanele kube amakhowe e-Reishi atshalwe ngendlela ejwayelekile, akhishwa, futhi acutshungulwa, anezithako ezisebenzayo eziphelele futhi anemvume yokudla kwezempilo.I-mushroom ye-Reishi kuphela engeke ikuvumele phansi.

【Umthombo Wedatha】

Jia-Tsrong Jan, et al.Ukukhonjwa kwemithi ekhona kanye nemithi ye-herbal njengama-inhibitors okutheleleka kwe-SARS-CoV-2.PNAS Febhruwari 2, 2021 118 (5) e2021579118;

https://doi.org /10.1073/pnas.2021579118.

PHELA

Mayelana nombhali/ Nks. Wu TingyaoWu

U-Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali we-"Ganoderma lucidum: Ingenious Beyond Description" (eshicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

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★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume ye-GanoHerb.

★ Uma imisebenzi igunyaziwe ukuthi isetshenziswe, kufanele isetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ibonise umthombo: GanoHerb

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