Ngaba iLingzhi inefuthe elithintelayo kwinoveli coronavirus (SARS-CoV-2)?Ngaba ukutya i-Lingzhi emva kokufumana inoveli inyumoniya (i-COVID-19) iyanceda ukucinezela inoveli coronavirus?

Besisoloko sisebenzisa umsebenzi we "Ganoderma lucidum's immune regulation" njengesiseko sethiyori ye "Ganoderma lucidum's anti-virus".Ngoku, ekugqibeleni kukho ubungqina obuthe ngqo bokusinika impendulo ecacileyo.

Ingxelo epapashwe liqela lophando laseTaiwan kwi-PNAS (Iinkqubo ze-National Academy of Sciences) ngoJanuwari 15 kulo nyaka (2021) iqinisekisile ukuba i-Ganoderma lucidum polysaccharides, enye yezinto eziphambili ezisebenzayo kwi-Ganoderma lucidum, inokuthintela ukusuleleka kweeseli nge. inoveli coronavirus, inqanda ukuphindaphinda kunye nokwanda kwenoveli coronavirus kwiiseli, kwaye inciphise inani le-coronavirus entsha emiphungeni emva kokuba izilwanyana zosulelwe yinoveli coronavirus.

Nqanda ukuphindaphinda kwentsholongwane ngaphandle kokwenzakalisa iiseli

Iqela lophando elikhankanywe ngasentla laqala ukwenza iimvavanyo ze-in vitro: okokuqala, iiseli zeVero E6 kunye nesicatshulwa seGanoderma lucidum polysaccharide (igama lekhowudi RF3) zakhuliswa kunye, emva koko i-coronavirus yenoveli yongezwa ukujonga inani lokuphindaphinda kwentsholongwane kunye nokusinda kweseli emva. iiyure ezingama-48.

Njengoko sonke sisazi, inoveli coronavirus ihlasela umzimba womntu nge-ACE2 receptor kwiseli.Iiseli zeVero E6 ezisuka kwizintso zeenkawu eziluhlaza zaseAfrika zinokuvakalisa inani elikhulu lee-receptors ze-ACE2, ke xa zidibana ne-coronavirus yenoveli, inoveli coronavirus inokungena lula kwezi seli ukuze iphindaphinde kwaye yande.

Iziphumo zibonisa ukuba i-Ganoderma lucidum polysaccharide extract inokunciphisa inani lokuphindaphinda kwentsholongwane kwisiqingatha kwi-concentration ephantsi ye-2 μg / mL ngaphandle kokubangela ukufa kweseli (jonga umfanekiso kunye nombhalo othathwe kwingxelo yophando engezantsi ukuze ufumane iinkcukacha).

Umthombo/PNAS February 2,2021 118(5) e2021579118

Ukunciphisa inani lentsholongwane kwimiphunga yeehamster

Inyathelo elilandelayo yayiluvavanyo lwezilwanyana: iihamster zaqala zasulelwa yinoveli coronavirus, kwaye emva koko i-Ganoderma lucidum polysaccharide extract yafakwa kwezi hamsters ngomlomo kwidosi yemihla ngemihla ye-200 mg / kg iintsuku ezi-3.

Kwafunyaniswa ukuba isixa sentsholongwane kwimiphunga ye-hamster sasimalunga nesiqingatha kuphela seqela lokulawula (ngaphandle kweziyobisi) (njengoko kuboniswe kumzobo ongezantsi), kwaye ubunzima be-hamsters abuzange buyeke kakhulu.Oku kuthetha ukuba isicatshulwa seGanoderma lucidum polysaccharide ayinakuthintela kuphela ukwanda kwenoveli coronavirus kodwa ikhuselekile kakhulu ukuyitya.

Umthombo/PNAS ngoFebruwari 2, 2021 118(5)e2021579118

Umthombo/PNAS February 2,2021 118(5)e2021579118

Musa ukuzijongela phantsi iziphumo zovavanyo lwe-“hamster”.Izicubu zokuphefumla ze-hamster ziyafana nezo zabantu.Xa i-immune system ikhuthazwa yintsholongwane, izicubu zokuphefumla ze-hamster nazo zinee-cytokines ezivuthayo ezifana nabantu.Ke ngoko, iziphumo zeReishi mushroom polysaccharide extract kunye nenoveli coronavirus elwa enye nenye kwiihamster zinexabiso elikhulu lokubhekisa.

I-polysaccharides ye-Reishi iphuma ngaphezu kwe-3,000 yeziyobisi kunye nezicatshulwa

Olu vavanyo lungentla lusibonisile ukuba iGanoderma lucidum polysaccharides inokukhusela iiseli kwaye ilwe nosulelo lwenoveli ye-coronavirus-ubuncinci xa ithathwa ngaphambi kosulelo okanye ngexesha lokuqala losulelo, iGanoderma lucidum polysaccharides inesiphumo esihle kakhulu sokulwa nentsholongwane.

Akukho lula ukuba i-Ganoderma lucidum polysaccharides inokugqama kolu phando.

Iqela lophando laqala laqokelela amayeza angama-2,855 omntu okanye ezilwanyana avunywe yi-US Food and Drug Administration (FDA).Okwesibini, iqela likhethe phantse izixhobo ezingama-200 zonyango ezineziphumo zonyango kusulelo lwentsholongwane oluvela kwiiklasiki zamayeza esintu aseTshayina.Okulandelayo, iqela livavanye amayeza ali-15 okanye izithako ezinokuthi zichane nosulelo lwentsholongwane kuvavanyo lweeseli olwenziwe kwilabhoratri ye-P3.

Iqela ke liye lawina amayeza asi-7 aphezulu okanye izithako kwimifuniselo yezilwanyana ukuya entloko kunye neentlobo zentsholongwane.Ekugqibeleni, zi-2 kuphela iintlobo zamachiza (ichiza lokulwa nesifo seengcongconi elibizwa ngokuba yi-mefloquine kunye neyeza lokulwa ne-AIDS elibizwa ngokuba yi-neflinavir) kunye neentlobo ezi-3 zamayeza esintu kunye neencindi zezityalo (i-Reishi mushroom polysaccharides, i-Perilla frutescens kunye ne-Mentha haplocalyx) zinokusebenzisa i-antiviral. iziphumo emzimbeni.

Phakathi kwezi zithako zintlanu, kuphela iGanoderma lucidum polysaccharides enokusebenza ngokuchasene neentsholongwane ngaphandle kokubangela ukufa kweeseli, ukwehla kobunzima okanye ukuchaphazela imisebenzi yomzimba.

Ngaphezu koko, i-polysaccharides enye kuphela yezithako ezisebenzayo kwi-Ganoderma lucidum.Ukuba sinokongeza i-triterpenes okanye sisebenzise yonke i-Ganoderma lucidum ukulwa nentsholongwane, kuya kwenzeka ntoni?

Izitofu zokugonya zinokukhusela kuphela ilungu elinye lomzimba wethu, kodwa yintoni ekufuneka isetyenziselwe ukukhusela indawo engenakukhusela izitofu?

Masitye ngakumbi iReishi mushroom!

Kwaye kufuneka ibe yi-Reishi mushroom eye yalinywa ngokusemgangathweni, ukutsalwa, kunye nokucutshungulwa, inezithako ezisebenzayo ezipheleleyo kwaye inemvume yokutya okunempilo.Kuphela i-mushroom ye-Reishi ayiyi kukuyeka.

【Umthombo wedatha】

Jia-Tsrong Jan, et al.Ukuchongwa kwamayeza asele ekhona kunye namayeza esintu njengezithinteli zosulelo lwe-SARS-CoV-2.PNAS ngoFebruwari 2, 2021 118 (5) e2021579118;

https://doi.org /10.1073/pnas.2021579118.

ISIPHELO

Malunga nombhali/ Nksz. Wu TingyaoWu

U-Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela kwi-1999. Ungumbhali we "Ganoderma lucidum: I-Ingenious Beyond Description" (epapashwe kwiNdlu yoPapasho lwezoNyango lwaBantu ngo-Ephreli 2017).

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