Umdlavuza yisifo esesabekayo esingalapheki esidla amandla emzimbeni, sibangele ukuncipha komzimba, ukukhathala okuvamile, i-anemia kanye nokungaphatheki kahle okuhlukahlukene.

Iziguli ezinomdlavuza ziyaqhubeka nokuhlukaniswa.Abanye abantu bangaphila nomdlavuza isikhathi eside, ngisho neminyaka eminingi.Abanye abantu bafa ngokushesha.Siyini isizathu somehluko onjalo?

Kuyini “ukuphila nomdlavuza”?

I-etiology kanye ne-pathogenesis yomdlavuza kuyinkimbinkimbi.Akunangqondo ukunqoba ngokuphelele yonke imidlavuza.Ukushaya umdlavuza akudingi ukubulala amangqamuzana omdlavuza ngokuphelele.Ukuvimbela ukukhula nokusabalala kwamangqamuzana omdlavuza kuvumela iziguli ukuthi ziphile namaseli omdlavuza isikhathi eside, okuyindlela futhi yokunqoba amangqamuzana omdlavuza.Ukuphila nomdlavuza kungafinyelelwa ngokuhlanganisa imithi yendabuko yamaShayina kanye nemithi yaseNtshonalanga.

Ngemva kokuthola ukwelashwa okuhlosiwe, i-radiotherapy noma i-chemotherapy, iziguli eziningi azigcini nje ngokulimala ngokomzimba kodwa futhi ziba buthakathaka ngenxa yezimpawu ezinjengobunzima bokudla, ukungasebenzi kahle kwamasosha omzimba, nokuhlanza njalo.Emithini yendabuko yamaShayina, ukungatheleleki komzimba kulingana ne-qi enempilo yomzimba womuntu.Ukuzivikela okubuthakathaka kusho ukunganele kwe-qi enempilo emzimbeni, okuzodala izifo.

Njengoba isisho sisho, umuthi wendabuko waseShayina uqinisa i-qi enempilo.Ukusetshenziswa komuthi wendabuko waseShayina kunganciphisa imiphumela emibi yezinye izidakamizwa, kuthuthukise i-tumor microenvironment, futhi kunqande ukukhula kwezimila.

I-Ganoderma lucidum, eyaziwa ngokuthi "imifino yomlingo", iyigugu endlini yengcebo yemithi yendabuko yaseShayina, futhi umsebenzi wayo oyinhloko ukuqinisa i-qi enempilo.

Izazi zaseMelika zeGanoderma: Isamba se-Triterpeneskusuka I-Ganoderma lucidumbabe nezindawo zokulwa ne-tumor.

Ngo-2008,Ijenali Yamazwe Ngamazwe Yesayensi Yamangqamuzanauveze ukuthi ucwaningo lwakamuva lukasosayensi waseMelika uDkt Daniel Sliva luthole lokhoI-Ganoderma lucidumi-triterpenoids ephelele (eyaziwa ngokuthiI-Ganoderma lucidumuwoyela we-spore) anezindawo zokulwa ne-tumor kanye ne-anti-inflammatory.

Ngokusekelwe esiphethweni socwaningo lweI-Ganoderma lucidumi-triterpenoids eyenziwe nguDkt Daniel Sliva, lesi sihloko siphinde siveze ukuthi ingqikithi ye-triterpenoidsI-Ganoderma lucidumequkethe i-ganoderic acid F ingakhawulela i-tumor angiogenesis in vitro kuyilapho i-ganoderic acid X ingakwazi ukusebenzisa ama-kinases alawulwa yisignali angaphandle kwamangqamuzana kanye nama-dual-specificity kinases, ngaleyo ndlela ibangele i-tumor cell apoptosis futhi ikhuthaze ukufa kwamaseli wesimila sesibindi somuntu.Ijenali Yamazwe Ngamazwe Yesayensi Yamangqamuzana ekugcineni uveza isiphetho socwaningo lukaDkt. Daniel Sliva:I-Ganoderma lucidum, okwemvelo "I-Ganoderma lucidumtriterpenes”, ingathuthukiswa ibe into entsha ngokusetshenziswa kwe-anti-tumor.(Fujian Agriculture, INqabayokulinda 2, 2012, amakhasi 33-33)

Isikhungo Sokucwaninga Ngomdlavuza WaseNdiya: I-Ganoderma lucidumama-triterpenes angavimbela ngempumelelo ukusinda kwamangqamuzana omdlavuza.

I-Amala Cancer Research Center yashicilela umbiko kuUcwaningo Lokuguqulwa KwezinguqukongoJanuwari 2017, eveza lokhoI-Ganoderma lucidumama-triterpenes angavimbela ngokuphumelelayo ukusinda kwamangqamuzana omdlavuza futhi anciphise ukuvela nokuqina kwamathumba kungakhathaliseki ukuthi asetshenziswa ngaphandle noma ngaphakathi.

Izinto zokuhlola ezisetshenziswe kulolu cwaningo yisamba esikhishwe yi-triterpene yomzimba othelayo weI-Ganoderma lucidum.Umphumela wokukhuliswa kwengqikithi ye-triterpene ekhishwe ngeseli yomdlavuza webele womuntu i-MCF-7 (encike ku-estrogen) ukuthi ukugcwala okuphezulu kwe-extract, isikhathi eside kusebenza kumaseli omdlavuza, futhi kunganciphisa izinga lokusinda. yamangqamuzana omdlavuza.Kwezinye izimo, kungenza ngisho namaseli omdlavuza anyamalale (okufanekiselwe ngezansi).

Ucwaningo luphinde lwathola ukuthi isizathu sokuthi kunganiI-Ganoderma lucidumingavimbela ukukhula kwamangqamuzana omdlavuza akukhona “ngodlame”, kodwa “ngokungeniswa” ukulawula izakhi zofuzo nama-molecule wamaprotheni kumaseli omdlavuza, kucishwe ukushintshwa kokwanda kwamangqamuzana omdlavuza, futhi kuqalise i-apoptosis yamangqamuzana omdlavuza.

(Wu Tingyao,I-Ganoderma, i-Indian Cancer Research Centre ikuqinisekisile lokhoI-Ganoderma lucidumi-triterpenoids inganciphisa ingozi yomdlavuza)

Zhibin I-Lin:I-Ganoderma lucidumisetshenziswa kakhulu ku-adjuvant chemotherapy kanye ne-radiotherapyumdlavuza.

USolwazi Zhibin Lin wasePeking University Health Science Centre, oke wafundaI-Ganodermaiminyaka engaphezu kwengu-50, okukhulunywe ngayo encwadini ethi “Khuluma mayelanaI-Ganoderma” ukuthi inani elikhulu lezifundo zemitholampilo kanye nemikhuba yezidakamizwa likufakazele lokhoI-Ganoderma lucidumingathuthukisa ukuzivikela komzimba okulwa nesimila, ithuthukise umphumela wokwelapha wemithi yokwelapha ngamakhemikhali, yehlise ubuthi nemiphumela engemihle efana ne-leukopenia, ukuqothuka kwezinwele, ukulahlekelwa ukudla, isicanucanu, ukuhlanza, isifo sohudo, ukwehla kwesisindo somzimba, ukulimala kwesibindi nezinso okubangelwa iradiotherapy kanye ukwelashwa ngamakhemikhali, nokwenza ngcono ukubekezelelana kweziguli ezinomdlavuza ekwelapheni ngamakhemikhali, kuthuthukise izinga lempilo yeziguli ezinomdlavuza futhi andise ukuphila kwazo.Nakuba inani elincane leziguli ezilahlekelwe ithuba le-radiotherapy kanye ne-chemotherapy ziye zathola imiphumela ethile yokwelapha ngeI-Ganoderma lucidumuwedwa,I-Ganoderma lucidumisetshenziswa kaningi ekwengezeni i-chemotherapy kanye ne-radiotherapy.

Ngokombono wezimiso zokwelapha ze-TCM "zokuqinisa i-qi enempilo nokuqeda izici ze-pathogenic", i-chemotherapy kanye ne-radiotherapy inaka kuphela "ukuqeda izici ze-pathogenic" nokunganaki "ukuqinisa i-qi enempilo", ngisho nokulimaza i-qi enempilo.Indima yeI-Ganoderma lucidumku-chemotherapy yomdlavuza kanye ne-radiotherapy yenza nje ukushiyeka kwalezi zindlela ezimbili zokwelapha, okungukuthi, "iqinisa ngempela i-qi enempilo futhi iqede izici ze-pathogenic".Umphumela we-multi-component kanye ne-multi-target anti-tumor effect ofI-Ganoderma lucidum, kanye nendima yayo ekuvikeleni ukulimala okubangelwa i-radiotherapy kanye ne-chemotherapy, incazelo yesimanje yomphumela "wokuqinisa i-qi enempilo nokuqeda izici ze-pathogenic".

(Ekuqaleni yashicilelwa ku-“Ganoderma”, 2011, Issue 51, amakhasi 2–3)

Ukuphila nomdlavuza akukona ukwelashwa okwenziwayo, ingasaphathwa eyokuyeka ukwelashwa.Igcizelela isimo “sokuphilisana ngokuthula” nomdlavuza.Ukugcina "ithemba + ukwelashwa" kungase kukwazi ukuzuza ukuphila isikhathi eside nomdlavuza.