October 2017 / Dicle University / Korean Journal ya Neurotrauma

Zolemba / Wu Tingyao

M’mbuyomu, zinkamveka kuti anthu ena anavulala kwambiri muubongo chifukwa cha ngozi.Kuphatikiza pa kulandira chithandizo chanthawi zonse, adatenganso zambiriGanoderma lucidum.Chotsatira chake, liwiro ndi zotsatira za kuchira zinali zosayembekezereka.Nkhani ya 63 (Spring 2014) ya "Healthy Ganoderma" yoperekedwa ndi Microbiology Culture and Education Foundation idawonetsanso milandu isanu ndi umodzi yogwiritsira ntchito.Ganoderma lucidumkuti asinthe zoopsa zomwe zimachitika chifukwa cha ngozi zagalimoto.

Is Ganoderma lucidumkotero "zamatsenga"?Lipoti lofalitsidwa mu "Korean Journal of Neurotrauma" (South Korea Journal of Neurotrauma) lolemba Dicle University ku Turkey mu October 2017 linatsimikizira kupyolera mu kuyesa kwa nyama kuti polysaccharide extract yaGanoderma lucidummatupi a zipatso amatha kufulumizitsa kuchira kwa kuvulala kwaubongo, ndipo kachitidwe kake kamakhala kogwirizana ndi kuchepetsa kupsinjika kwa okosijeni ndikuchepetsa kutupa.

Ofufuzawa adagwiritsa ntchito njira yopangira "kugwa kuchokera kutalika" kuti awononge ubongo mu makoswe.Theka la iwo (16 makoswe) sanalandire chithandizo chilichonse (gulu lachisokonezo chaubongo).Theka lina (kuvulala muubongo +Ganoderma lucidumgroup) adadyetsedwa ndiGanoderma lucidum pa mlingo woperekedwa tsiku ndi tsiku wa 20 ml pa kilogalamu ya kulemera kwa thupi mphindi 30 pambuyo pa zoopsa (mL iliyonse yaGanoderma lucidumchotsitsa chamadzi chimakhala ndi 2 mg ya polysaccharides).Kuvulala kwaubongo kwa makoswe kumawunikidwa patatha masiku asanu ndi awiri.Kuyeserako kwagwiritsanso ntchito makoswe wamba (gulu lolamulira) ndi makoswe wamba omwe amadyetsedwa nawoGanoderma lucidumpolysaccharide(Ganoderma lucidumgroup) kufananiza ndi magulu awiri apitawa.

Kutaya magazi muubongo kungayambitse kutupa, kuonjezera mphamvu ya okosijeni mu ubongo (ma enzymes a antioxidant adzachepa, ndipo chiwerengero cha ma free radicals chidzawonjezeka), komanso chingayambitse edema (yomwe imafinya minofu ya ubongo ndi kuiwononga).Chotchinga choyambirira cha magazi ndi ubongo (chotchinga chachilengedwe pakati pa mitsempha yamagazi ndi ubongo chomwe chingatseke zinthu zakunja kulowa muubongo) chidzawonongedwanso, zomwe zimapangitsa kuti maselo oyera ambiri alowe muubongo kapena kuyambitsa matenda muubongo, zomwe zimapangitsa kutupa kwambiri. .

Izi sizikuthandizira kuchira kwa minofu ya muubongo ku zoopsa.Koma malinga ndi zotsatira za kuyesa kwa nyama mu lipoti ili, makoswe opwetekedwa ndi ubongo atachiritsidwaGanoderma lucidumpolysaccharide kwa masiku asanu ndi awiri, minofu yawo yaubongo imawonongeka pang'ono ndi ma free radicals (MDA imachepetsa), enzyme ya antioxidant GSH yomwe imalepheretsa ma radicals aulere muubongo imawonjezeka, kutupa kwa maselo oyera amagazi kumakhala kochepa kwambiri (kutulutsa kwa peroxidase MPO kumakhala kochepa), ubongo. edema imakhalanso bwino kwambiri, ndipo kutsekemera kwa chotchinga cha magazi-muubongo kumakhalanso pafupi kwambiri ndi chikhalidwe- makhalidwe onse ndi osiyana kwambiri ndi makoswe opwetekedwa ndi ubongo omwe sanalandire chithandizo chilichonse (onani tebulo ili m'munsimu).

Kuphatikiza apo, zitha kuwoneka kuchokera kumagulu amtundu wa cerebral cortex omweGanoderma lucidumma polysaccharides amatha kusintha kufalikira kwa mitsempha yamagazi ndi edema, kukonza ma cell a mitsempha, ndikufulumizitsa kuchira kwa ubongo wovulala (monga momwe tawonetsera pansipa).Ubongo wa cerebral cortex umatanthawuza mawonekedwe olumikizana ngati khungu okhala ndi makwinya ambiri atakulungidwa kunja kwa ubongo.Ndilo udindo wa kumverera kwapamwamba ndi luso la kulingalira.Choncho, kuchira kwa derali n'kofunika kwambiri.

Ofufuzawa adayesanso zizindikiro zina zitatu zofunika mu minofu ya ubongo wa makoswe, kuphatikizapo protein kinase p38 MAPK, yomwe imagwirizana bwino ndi kutupa, vascular endothelial growth factor (VEGF), yomwe ndi yofunikira kukonza dongosolo la mitsempha, ndi microglial cell, yomwe imayambitsa kuchotsa maselo owonongeka a mitsempha ndi tizilombo toyambitsa matenda.

Zinapezeka kuti, poyerekeza ndi ubongo-ovulazidwa makoswe omwe sanadyeGanoderma lucidumma polysaccharides, ngakhale ntchito ya p38 MAPK idapezekabe mu makoswe ovulala muubongo omwe adadya.Ganoderma lucidumma polysaccharides, (zomwe zikuwonetsa kuti zomwe zikuchitikazo zikupitilira koma zidayendetsedwa ndipo sizingaipire), zomwe zimayambitsa kukula kwa mitsempha yamagazi ndi ma cell a microglial zidakula kwambiri, zomwe zikuwonetsa kutiGanoderma lucidumpolysaccharide imathandiza kukonza ndi kumanganso ziwiya zaubongo ndi mitsempha ya cranial.

Zotsatira zoyesera zomwe zili pamwambazi zikuwonetsa zotsatira za kayendetsedwe kosalekeza kwaGanoderma lucidumma polysaccharides kwa masiku asanu ndi awiri ubongo utavulala.Ofufuza amakhulupirira kuti ngati mlingo woyenera waGanoderma lucidumma polysaccharides atha kugwiritsidwa ntchito ngati chithandizo chothandizira pambuyo povulala muubongo, zitha kukhala zothandiza kwambiri pakuchepetsa kutupa ndi edema yaubongo, kapena kuteteza maselo amitsempha ndi ma cell a glial.

[Source] Özevren H, et al.Ganoderma Lucidum imateteza minyewa yaubongo wa makoswe motsutsana ndi kupsinjika kwa okosijeni komwe kumachitika chifukwa cha zoopsa.Korea J Neurotrauma.2017;13(2): 76-84.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba

★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba

★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake walamulo

★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.