NgoJulayi 2, 2016 / iSibhedlele saseXiangya kwiYunivesithi yaseCentral South, njl. / Ijenali yeHlabathi yeBiological Macromolecules
Umbhalo / Wu Tingyao

Abanye oogqirha babekhe basebenzisa “iphedi yokukhuhla” ukuchaza inkangeleko yemiphunga yefibrotic.Ngeli xesha, i-alveoli ilahlekelwe ngumsebenzi wokutshintsha umoya, ochaphazela kakhulu ukuphefumla.Ambalwa amayeza athile okunyanga.Umyinge weminyaka emihlanu wokuphila kwezigulana ezine-pulmonary fibrosis ungaphantsi kunalowo wezigulane ezinomhlaza wemiphunga.Ngoko ke, ngaphandle kokuba i-pulmonary fibrosis ifunyenwe kwinqanaba lokuqala, oko kukuthi, xa udonga lwe-alveolar luvutha, kukho ithuba elingcono lokuthintela okanye ukulibazisa ukuwohloka kwesifo.Xa sele ifikelele kwinqanaba le-tissue fibrosis, unyango lunzima kakhulu.Ukuphazamiseka kokuphefumla kwangoko, ukuphefumla kancinci kunye nokukhohlela okomileyo kuhlala kungahoywa zizigulana okanye kujongwe kakubi ngoogqirha.Ke ngoko, xa uninzi lwezigulana zifunyaniswa zine-pulmonary fibrosis, ziye zangena kumanqanaba aphakathi kunye nasekupheleni kwesi sifo.

Ukutshaya, i-reflux ye-gastroesophageal, iimpembelelo zokusingqongileyo, i-genetics, ukuguqulwa kofuzo, iziyobisi kunye nezinye izinto ezinokubangela umonakalo wemiphunga kunye nokuvuvukala okugqithisileyo ixesha elide, okukhokelela ekuveleni kwe-pulmonary fibrosis.Nangona kunjalo, ukuba imiphunga inokukhuselwa ngeI-Ganoderma lucidumngelo xesha, ingxaki ye-pulmonary fibrosis ingasombululwa.

Uphando olwenziwe liSebe lezoNyango lokuphefumla, iSibhedlele sase-Xiangya kwiYunivesithi yaseCentral South, ngokubambisana kunye neeyunithi ezininzi, ziqinisekisile ukuba i-polysaccharides evela.I-Ganoderma lucidum(PGL) inokuthintela kwaye inyange i-pulmonary fibrosis ebangelwa lichiza elichasene nomhlaza ibleomycin.Esi siphumo sipapashwe kwi-International Journal ye-Biological Macromolecules ngoJulayi 2016.