4月に 2024, a research team jointly led by Professor Jia Li and Associate Professor Xie Xiaodong from the Biomedical Research Center of the College of Materials and Chemical Engineering, ンジャン大学, in collaboration with the College of Chemistry, 福州大学, the School of Pharmacy, 福建中医薬大学, the Translational Research Centre in Onco-Hematology (CRTOH), Faculty of Medicine, University of Geneva, Switzerland, and Fujian Xianzhilou Biological Science and Technology Co., 株式会社. (福州), published a study in the Journal of the Chinese Medical Association.
The study demonstrated that マンネンタケ 胞子油 (GLSO) can enhance the effect of the chemotherapeutic drug cyclophosphamide (CTX) in inhibiting breast cancer lung metastasis in animals, with the mechanism linked to an enhancement of anti-tumor immunity.
霊芝ルシダム Spore Oil: Rich in Active Ingredients
の マンネンタケ 胞子油 (GanoOil) used in this study was extracted by Fujian Xianzhilou Biological Science and Technology Co., 株式会社. (福州) from a specific source of マンネンタケ spore powder using supercritical CO2 抽出. Analysis by the research team confirmed that this spore oil is rich in ergosterol (約 230 mg per 100 g of spore oil), Reishi total triterpenoids (約 34-35 g per 100 g of spore oil), and various unsaturated fatty acids (下の図に示すように).
霊芝胞子油: High Safety and Immune-Boosting Properties
The research team also evaluated the safety of マンネンタケ spore oil through in vitro and in vivo experiments. They cultured different concentrations of spore oil with various cancer cells or normal cells for 24 hours to observe cell viability. さらに, healthy mice without tumors were orally administered 0.5 g/kg of マンネンタケ spore oil daily for 28 日. The results showed:
➤ The viability of both cancer cells and normal cells is unaffected by マンネンタケ 胞子油 (indicating no toxic damage).
➤ No significant changes in body weight were observed in the mice during the experiment.
➤ At the end of the experiment, important organs like the heart, 肝臓, 脾臓, 肺, and kidneys of the mice were all normal (no toxic reactions or pathological changes occurred).
Histopathological analysis showed no significant differences in organ tissues between the two groups, indicating that long-term daily administration of high doses (0.5g/kg) の マンネンタケ spore oil had no apparent toxicity or side effects in mice.
➤ The activity of natural killer (NK) cells and the overall number of lymphocytes (including T cells, B cells, and NK cells) in the mice’s spleens significantly increased.
➤ There was also a tendency for an increase in CD8+ T cells (細胞傷害性T細胞), which can directly kill cancer cells or pathogens, in the mice’s blood circulation. Although the increase did not reach statistical significance, it still suggests a positive impact of マンネンタケ spore oil on immunity.
These results indicate that daily oral administration of high-dose マンネンタケ spore oil is not only safe for consumption but also beneficial for enhancing immunity.
霊芝ルシダム Spore Oil できる Assist Chemotherapeutic Drugs in Reducing Lung Metastasis
The researchers further investigated the in vivo anti-cancer effect of マンネンタケ spore oil using an experimental model of breast cancer lung metastasis. During the 21-day experimental period, mice were orally administered 0.3 g/kg of マンネンタケ spore oil daily. Three days after starting spore oil administration, metastatic triple-negative breast cancer 4T1 cells were intravenously injected into the mice. The chemotherapeutic drug CTX (cyclophosphamide) was administered via intraperitoneal injection at a dose of 0.05 g/kg, for a total of 3 injections. The results showed:
➤ Tumor-bearing mice receiving both マンネンタケ spore oil and CTX chemotherapy had significantly fewer tumors in their lungs compared to groups receiving no treatment, マンネンタケ spore oil alone, or chemotherapy alone. This indicates that the combined use of マンネンタケ spore oil and CTX has a better inhibitory effect on breast cancer cell metastasis from the bloodstream to the lungs.
➤ In tumor-bearing mice treated concurrently with マンネンタケ spore oil and the chemotherapeutic agent CTX, not only was their body weight not significantly different from that of normal mice, but the ratios of lung weight and spleen weight to body weight were also very similar to those of normal mice. This indicates that the combined use of マンネンタケ spore oil and CTX can prevent weight loss and abnormal enlargement of the lungs and spleen typically caused by cancer itself and by chemotherapeutic drugs.
➤ While combined use of マンネンタケ spore oil and chemotherapy did not increase the proportion of CD4+ T cells among lymphocytes, it did increase the proportion of CD8+ T cells (cytotoxic T cells that can directly kill cancer cells) in the blood, enhanced the activity of natural killer cells in the spleen, and promoted the content of the cytokine IL-6 in the blood. したがって, の能力 マンネンタケ spore oil to assist chemotherapeutic agents in preventing breast cancer cell metastasis to the lungs is likely achieved through the enhancement of anti-tumor immunity.
霊芝ルシダム Spore Oil: Both a Health Food and a Chemotherapy Adjuvant
Based on the above research findings, it can be concluded that daily supplementation with マンネンタケ spore oil can enhance immunity before tumor onset. When tumors are present, daily supplementation with マンネンタケ spore oil can also improve the inhibitory ability of chemotherapeutic drugs on cancer metastasis.
したがって, マンネンタケ spore oil is not only a daily health food but also a beneficial chemotherapy adjuvant. さらに重要なことは, its high dietary safety means it does not cause harm or burden to the heart, 肝臓, 脾臓, 肺, or kidneys.
Everyone has cancer cells, but not everyone develops cancer; even if cancer occurs, metastasis doesn’t always happen. The key lies in anti-tumor immunity. Immunity can be weakened by factors such as age, ストレス, pollution, illness, and medication. したがって, it’s crucial to maintain immunity daily, even when healthy. Long-term maintenance of good immunity is a self-protective measure against cancer and for fighting it.
参照:
Shu Lian, 他。マンネンタケ spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis. J Chin Med Assoc. 2024 3月 1;87(3):305-313.
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★ The original manuscript of this article was authored in Chinese by Wu Tingyao and subsequently translated into English by Alfred Liu. 英語翻訳と元の中国のテキストとの間に矛盾がある場合, 後者は優先されるものとする. 任意のクエリ用, PLSは元の著者に手を差し伸べます, MS. 呉廷耀.
