Naphezu kwezinguquko eziningi emhlabeni, okuhlala kungashintshile ukuthi umdlavuza wamaphaphu useyinkinga enkulu empilweni yomuntu;naphezu kokwethulwa ngokuphindaphindiwe kwezidakamizwa ezilwa nomdlavuza, izidakamizwa zendabuko ze-chemotherapy zisengububi obudingekayo ezimweni eziningi.

Nokho, uma amangqamuzana avamile engavikelekile kahle, kungakhathaliseki ukuthi ukwelapha ngamakhemikhali kunamandla kangakanani, kuyoba nzima ngesiguli ukukuthwala.

Ungazivikela kanjani ngesikhathi se-chemotherapy?Thatha umphumela we-chemotherapy ngangokunokwenzeka futhi uqede ubuthi be-chemotherapy?Inhlanganisela neI-Ganoderma lucidumama-polysaccharides ngesikhathi sokwelashwa ngamakhemikhali kuyindlela efanele ukucatshangelwa.

Ucwaningo olushicilelwe kumagazini kaDisemba 2021 we- "International Journal of Biological Macromolecules" nguSolwazi Ohlangene uTung-Yi Lin et al.kusukela ku-Institute of Traditional Medicine ye-National Yang Ming Chiao Tung University e-Taiwan kufakazele ngokuhlolwa kwamaseli nezilwane ukuthiI-WSG (i-Water Soluble Polysaccharide etholakala ku-I-Ganoderma lucidum)ayikwazi nje ukuthuthukisa umphumela ovimbelayo womuthi we-chemotherapy i-cisplatin ku-lung adenocarcinoma kodwa futhi ivikele amaseli omzimba namaseli avamile futhi ikhulise kakhulu izinga lokusinda kwezilwane ezihlolwayo. 

Ukuhlolwa kwamaseli kubonise ukuthi inhlanganisela ye-WSG ne-cisplatin ikhuphule ukusebenza kahle kwe-cisplatin futhi yehlisa ubuthi be-cisplatin.

Abacwaningi bahlanganise ukuphathwa kwe-WSG ne-cisplatin ukuze babone imiphumela yabo kumaseli wamaphaphu e-adenocarcinoma namaseli ajwayelekile e-vitro.

Kutholwe ukuthi noma ngabe imelene namaseli e-adenocarcinoma yamaphaphu omuntu noma amaseli egundane lamaphaphu e-adenocarcinoma, i-WSG (i-Water Soluble Polysaccharide etholakalaI-Ganoderma lucidum) "kungathuthukisa" ukubulawa kwe-cisplatin kumaseli omdlavuza (okungukuthi, ukuthuthukisa i-apoptosis yamaseli omdlavuza);ngokuphambene nalokho, kungakhathaliseki ukuthi yayimelene namaseli ezicubu zamaphaphu ezivamile zomuntu noma ama-macrophage egundane, i-WSG “inganciphisa” umonakalo we-cisplatin kumaseli avamile.

I-WSG iyodwa ayinawo umonakalo kumaseli omdlavuza namaseli avamile kuyilapho i-cisplatin iyodwa ingalimaza womabili amangqamuzana omdlavuza namaseli avamile.Kodwa-ke, ukuphathwa okuhlangene kwe-WSG ne-cisplatin kunganciphisa izinga lokusinda kwamangqamuzana omdlavuza futhi kulwele ukuthola indawo eyengeziwe yokusinda kumaseli avamile, okubonisa ukuthi i-WSG inomphumela wokwandisa ukusebenza kahle kwe-cisplatin nokunciphisa ubuthi be-cisplatin.

Ukusebenza kweseli kwamaseli e-adenocarcinoma yamaphaphu, i-WSG kanye ne-cisplatin kuhlanganiswe amahora angama-24

Ukusebenza kweseli kwamaseli avamile akhuliswe nge-WSG noma i-cisplatin amahora angu-24

Ukusebenza kweseli kwamaseli avamile, i-WSG kanye ne-cisplatin kuhlanganiswe isikhathi esingu-24h

Ukuhlolwa kwezilwane kubonisa ukuthi ukuphathwa okuhlanganisiwe kwe-WSG ne-cisplatin kunciphisa ukukhula kwesimila.

Abacwaningi baphinde bafaka umugqa weseli wegundane we-adenocarcinoma esicutshini esingaphansi kwamagundane okuhlola.Ngaphansi kwesimo sokuthi amasosha omzimba nawo abandakanyeka ekulweni nomdlavuza, abacwaningi babone umphumela we-WSG ongena emzimbeni ekwelapheni i-cisplatin.Ngemuva kwezinsuku ezingama-21 zokuhlolwa, abacwaningi bathola ukuthi i-WSG iyodwa noma i-cisplatin iyodwa ingenza isimila sikhule kancane futhi sibe sincane, futhi umphumela wokuvimbela isimila we-WSG wawungekho ngaphansi kwalowo we-cisplatin, kodwa umphumela ohlangene we-WSG (Water Soluble). I-Polysaccharide etholakala ku-I-Ganoderma lucidum) futhi i-cisplatin ihamba phambili.

Umphumela ovimbelayo we-WSG, i-cisplatin noma kokubili ekukhuleni kwe-lung adenocarcinoma

Ukuhlolwa kwezilwane kubonisa ukuthi i-“WSG + cisplatin” yehlisa ukuvela kwesimila futhi ithuthukisa ukusebenza.

Abacwaningi baphinde benza olunye ucwaningo lwezilwane, bajova umugqa weseli wamaphaphu we-adenocarcinoma emthanjeni womsila wegundane, base beyelapha nge-WSG, i-cisplatin noma kokubili, babona nenani lezimila noma izigaxana ezazikhule emaphashini kanye nokusinda. amagundane ngemva kwezinsuku ezingu-21.Bathole ukuthi i-WSG, i-cisplatin noma ukuphathwa okuhlangene kwakho kokubili kungavimbela ukwakheka kwezimila noma izigaxana, futhi kungandisa impilo yamagundane e-adenocarcinoma yamaphaphu, kodwa iqembu elisebenza kahle kakhulu bekungalindelekile amagundane e-adenocarcinoma ephathwa nge-WSG kuphela.I-WSG (i-Water Soluble Polysaccharide etholakala ku-I-Ganoderma lucidum) idlala ngokucacile indima ebalulekile ekuthuthukiseni ukusebenza komzimba nokuvikela amangqamuzana avamile.

Ukuvinjelwa kokukhula kwezimila noma amaqhuqhuva emaphashini yi-WSG, i-cisplatin noma womabili kanye nomthelela wawo esikhathini sokuphila

I-WSG inhle ngokulinganayo ekuhlaseleni nasekuvikeleni ekulweni nomdlavuza.

Umthelela we-WSG ekuvimbeni isimila kanye nokuvikela impilo ekuhlolweni kwezilwane awukho ngaphansi noma ungcono nakakhulu kunalowo we-cisplatin iyodwa noma uhlanganiswe ne-cisplatin, okubangelwa kakhulu ukuthi i-WSG (Water Soluble Polysaccharide etholakalaI-Ganoderma lucidum) iyakwazi ukucindezela amaseli omdlavuza ngokushesha nje lapho evela.

Lapho sibhekene namangqamuzana omdlavuza angakakhuli futhi akhiwe abe izimila, inqobo nje uma singasebenza kanzima ngokushesha ukuze sithuthukise ukusebenza kwamasosha omzimba futhi sivikele amangqamuzana avamile, kuba lula ngaso sonke isikhathi ukunciphisa umonakalo wamangqamuzana omdlavuza.

Ngakho-ke, imiphumela yocwaningo engenhla ayinikezi nje kuphela isisekelo sereferensi sokuthuthukisa ukusebenza ngempumelelo kanye nokunciphisa ubuthi bemithi yokwelapha ngamakhemikhali kodwa futhi ifakazela ukuthi ukusetshenziswa kwe-WSG ngesikhathi sokwelashwa ngamakhemikhali ngokuqinisekile kuwukuhlanganisa esikhundleni sokususa noma ukuphazamiseka, futhi kusikhumbuza ukubaluleka kanye nokwelashwa ngamakhemikhali. ukuba nokwenzeka kokuthatha izinyathelo zokuvimbela kwasekuqaleni.

Kulolu cwaningo kuphela, i-WSG yanikezwa izilwane zokuhlola ngomjovo we-intraperitoneal.Ukusebenza kahle kokumuncwa kwe-peritoneal emgudwini wamathumbu kuyashesha kunalokhu okuthathwa ngomlomo, futhi umthamo we-intraperitoneal nawo ungaphansi komthamo odingwa ngokuphathwa ngomlomo.Ngakho-ke, ukuthi ungakanani umthamo we-WSG odinga ukuthathwa ngomlomo ukuze uthole umphumela ofanayo nomjovo we-intraperitoneal ufanele ukudingidwa kabanzi ngabacwaningi.

[Umthombo] Wei-Lun Qiu, et al.I-WSG, i-Glucose-Rich Polysaccharide evelaI-Ganoderma lucidum, Kuhlanganiswe ne-Cisplatin Potentiates Inhibition of Lung Cancer In Vitro kanye ne-In Vivo.Ama-Polymers (i-Basel).2021;13(24):4353 .

PHELA

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