Ubhubhane olusha lwe-coronavirus selucekele phansi isintu iminyaka emithathu kuze kube manje.Kusukela ngoDisemba 2022, ukuhlolwa okujwayelekile kwe-nucleic acid kukhanseliwe ezindaweni eziningi kulo lonke elase-China, futhi isitifiketi sokuhlolwa kwe-nucleic acid esinegethivu se-COVID-19 ngeke sisabhekwa.I-China ingene enkathini yokuba khona ngokubambisana nalolu bhubhane.Ukubhekana nenani eliphakeme lezifo, indlela yokuthuthukisa ukungatheleleki futhi ube umuntu wokuqala onesibopho sempilo yakho sekube yisihloko esikhathaza kakhulu umphakathi wonke.

Njengoba izinzuzo zemithi yendabuko yamaShayina ekuvimbeleni nasekulawuleni lolu bhubhane sezivele zigqama kakhulu, "I-Ganoderma lucidum", enomphumela wokuthuthukisa ukungatheleleki kanye nokugcina ibhalansi yomsebenzi wonke, yenze kahle kakhulu ekuvimbeleni nasekulawuleni ubhubhane.

Ngakho, kwenzaI-Ganoderma lucidumingabe kukhona umthelela ovimbelayo ku-coronavirus yenoveli?Ingabe iziguli ezine-COVID-19 zingadlaI-Ganoderma lucidumukuze ube nomphumela omuhle emzimbeni?Imiphumela eminingi yocwaningo yakamuva isinikeza ubufakazi obuhle.

Ngo-Ephreli 2020, iphephabhuku lezemfundo lamazwe ngamazweAma-moleculeishicilele "Izinhlanganisela Zemvelo Zemvelo ezivela kuFungi Njengabangase Bangakwazi Ama-Protease Inhibitors kanye nama-Immunomodulators ukuze Bafake Isicelo SeCoronavirus".

Leli phepha libuyekeza ukutholakala kanye nenqubekelaphambili yocwaningo lwezinhlanganisela zemvelo ezisebenzayo zesikhunta ekuvimbeleni i-human immunodeficiency virus (HIV) protease.Iphakamisa ukuthi izinhlanganisela ezisebenzayo zesikhunta, ikakhulukaziI-Ganoderma lucidum(ama-triterpenoids, ama-polysaccharides kanye namaphrotheni amangqamuzana amancane) adlala indima ebalulekile ekuvimbeleni igciwane lesandulela ngculazi (HIV) protease.

Lolu cwaningo luhlinzeka ngomuntu ongase abe yisidakamizwa sokuvikela nokwelashwa kwe-coronavirus, engasetshenziswa esikhathini esizayo ukuvimbela nokwelapha ama-coronavirus, ikakhulukazi ukuvimbela nokwelashwa kwezifo ze-coronavirus.

Ngo-2021, "Izinqubo zeNational Academy of Sciences (PNAS) 2021 Vol.118 No.5″ ishicilele isihloko esithi “Ukuhlonzwa Kwama-Inhibitors of Novel Coronavirus Infection from Listed Drugs and Herbal Medicines”.Ucwaningo luthole ukuthiI-Ganoderma lucidumukukhishwa kwamanzi kunganqanda kakhulu ukutheleleka kwenoveli coronavirus (SARS-Cov-2) kokubili ku-vivo kanye ne-in vitro.

Umuthi we-herbal waseShayina ukhiphe amanzi (1.0 g/20 mL, 5%) kanyeI-Ganoderma lucidumi-polysaccharide RF3 (0.25 mg/mL, 0.025%).IC50=isilinganiso sokuvimbela (igciwane);CC50=isigamu sethamo elinobuthi

Imiphumela iyakufakazela lokhoI-Ganoderma lucidumi-polysaccharide RF3 (2μg/ml) inomthelela omkhulu wokunqanda amagciwane ku-SARS-Cov-2 ekhuliswe ku-vitro, futhi isenomsebenzi ovimbelayo lapho ihlanjululwa izikhathi eziyi-1280.Kepha ayinabo ubuthi kumaseli we-Vero E6 abamba igciwane.

(A) Abacwaningi babone imiphumela ye-anti-sars-cov-2 yezidakamizwa nokukhishiwe kuma-hamster.Ngosuku lwe-0, ama-hamster angenwa yi-intranasal instillation ye-SARS-CoV-2.Kamuva, ama-hamster aphathwa ngomlomo umuthi (30mg/kg/d) kanye nokukhishwa kwemithi yendabuko yamaShayina (200mg/kg/d), kabili/d, kanti umthamo wegciwane egazini emaphashini ama-hamster ukalwa ngemva kwezinsuku ezi-3. n=5), *P <0.05 ;* * P <0.005(B) Ukushintsha kwesisindo somzimba ngemva kokwelashwa kwe-3-d, N=5 eqenjini lokuhlola, N=6 eqenjini lokulawula.Imiphumela yafakazela ukuthi uma kuqhathaniswa neqembu lokulawula ukutheleleka, ukuphathwa ngomlomo kweI-Ganoderma lucidumi-polysaccharide RF3 inganciphisa kakhulu umthamo wegciwane egazini (okuqukethwe) emaphashini ama-hamster angenwe igciwane le-SARS-Cov-2, futhi izilwane azizange zehle isisindo ngesikhathi sokuhlolwa.Ukuhlolwa kwe-in vivo kanye ne-in vitro antiviral kufakazele lokhoI-Ganoderma lucidumi-polysaccharide RF3 ivimbele kakhulu ukutheleleka kwe-SARS-Cov-2.

NgoFebhuwari 2020, uSolwazi Sun Guifan, iphini likasihlalo wePrecision Nutrition Professional Committee ye-China Nutrition and Health Food Association, kanye ne-Institute of Preventive Medicine yase-China Medical University, bakhipha esidlangalaleni isihloko esithi “Isihloko sesibili esidumile sochungechunge lwesayensi mayelana nosizo olunembile. ekuvimbeleni nasekwelapheni ukutheleleka kwe-coronavirus yenoveli mayelana nokudla okunomsoco - umsebenzi wezithako zokudla okunomsoco", kumenyezelwe umphakathi izinhlobo eziyi-12 zezithako zokudla okunomsoco ezingasiza ekuvimbeleni nasekwelapheni ukutheleleka kwe-coronavirus, okuhlanganisaI-Ganoderma lucidum, umuthi wesintu waseShayina!

Esihlokweni, uProfesa Sun wakuveza ngokucacile lokhoI-Ganoderma luciduminomphumela wokuvuselela umzimba, ongathinta ngokuqondile ikhono layo lokulwa nezifo ezibangelwa amagciwane kanye namagciwane.Ucwaningo lwamaseli elabhorethri luye lwabonisa ukuthi ukukhishwa kwe-Reishi kungamisa noma kubambezele ukukhula kwegciwane lomkhuhlane, i-HIV, i-hepatitis B namanye amagciwane amaningi, okubuyisela ukwehla okuhlobene neminyaka ekusebenzeni kwamasosha omzimba.

USolwazi uZhi-Bin Lin wasePeking University Health Science Centre, ogxile ocwaningweni lwemithiI-Ganoderma lucidumiminyaka engaphezu kwengu-50, wethula umphumela we-antiviral kanye nomshini weI-Ganoderma lucidumesihlokweni esithi “Antiviral Effect ofI-Ganoderma lucidum” eshicilelwe ekupheleni kuka-2020, ikhomba lokhoI-Ganoderma lucidum, ikakhulukazi ama-triterpenes aqukethwe kuwoI-Ganoderma lucidum, ibe nemiphumela evimbelayo ezinhlobonhlobo zamagciwane.

USolwazi Zhi-Bin Lin uhlaziye kuqala indlela yomphumela we-antiviral weI-Ganoderma lucidum, okubandakanya ukuvimbela ukukhangiswa noma ukungena kwamagciwane kumaseli, ukuvimbela ukuqaqa igciwane, ukuvimbela umsebenzi wama-enzyme (njenge-reverse transcriptase ne-protease) adingekayo ekuhlanganiseni kwegciwane kumaseli, nokuvimbela i-viral DNA noma i-RNA ukuphindaphinda kodwaI-Ganoderma lucidumayinabo ubuthi bokusingatha amaseli futhi inomphumela we-synergistic uhlanganiswe nemithi eyaziwayo elwa namagciwane.

Lesi sihloko siphinde saveza ukuthi ukusebenza kahle komtholampilo kweI-Ganoderma lucidumezifweni ezibangelwa amagciwane zingase zihlobane ngokuyinhloko nomphumela wokulawulwa kwamasosha omzimba weI-Ganoderma lucidum, i-anti-oxidation kanye nomphumela wamahhala wokulahla we-radicalI-Ganoderma lucidum, kanye nomphumela wokuvikela weI-Ganoderma lucidumezithweni nasezicutshini.

Ucwaningo lwanamuhla lubonisa lokhoI-Ganoderma luciduminothe ngezithako eziningi ezisebenzayo, “okuyisithunywa” sokuthuthukisa amasosha omzimba.

Ngokuvamile, ukuphakama kwezithako ezisebenzayo, kuba ngcono umphumela wokuthuthukisa ukungatheleleki.

Kusukela ngo-2017, i-GanoHerb kanye ne-Fujian Provincial Center for Disease Control and Prevention ngokuhlanganyela yethula iphrojekthi yocwaningo ethi “UmphumelaI-Ganoderma LucidumAma-Granules Kumsebenzi Wamasosha omzimba”.Amagundane ahlukaniswa amaqoqo amahlanu, futhi anikezwa imithamo ehlukeneI-Ganoderma lucidumama-granules (nge-GanoHerb Technology (Fujian) Corporation).

Ngokuqhathanisa iqembu ngalinye lomthamo wesampula neqembu elilawulayo, kutholwe ukuthi: ①Iqembu lesampula lomthamo omkhulu lithuthukise kakhulu ikhono lokwanda kwama-lymphocyte wobende begundane abangelwe yi-ConA kanye nokuzwela kohlobo olubambezelekile lwamagundane oludalwe i-DNFB;②Amaqembu anethamo eliphakathi nendawo neliphezulu alithuthukisa kakhulu ikhono lokukhiqiza i-antibody, iqembu ledosi ephezulu lenyuse kakhulu izinga le-serum hemolysin kumagundane;③Iqembu lesampula ledosi ephezulu lithuthukise kakhulu umsebenzi wamaseli e-NK kumagundane.

Isiphetho esithathwe ekuhlolweni ukuthi ama-Ganoderma granules akhiwe ngeI-Ganoderma lucidumkhipha futhiI-Ganoderma sinensei-extract inomsebenzi wokuthuthukisa ukungatheleleki.Njengenkampani ehamba phambili egxile embonini yezempilo yakwaGanoderma, selokhu kwaqubuka lolu bhubhane ngo-2020, iGanoHerb inikele ngesamba semali eyizigidi eziyi-9.126 zamayuan nezinto zokwakha ezihlanganisa.I-Ganoderma lucidumi-spore oil,I-Ganoderma lucidumspore powder kanyeI-Ganoderma lucidumikhiphe ukusiza abasebenzi bezokwelapha abaphambili kanye nabanye abasebenzi ukuthi bathuthukise ukungatheleleki kwabo komzimba futhi bakhe umugqa wokuzivikela onempilo ndawonye.Kungenxa yalo mthwalo kanye nokuzibophezela kwawo ukulwela ukulwa nalolu bhubhane okwathi ngo-2021, i-GanoHerb Technology (Fujian) Corporation., inkampani engaphansi kwe-GanoHerb Group, yaklonyeliswa nge-“Fujian Province Advanced Private Enterprise in Fighting against the Novel Coronary Pneumonia. Umqedazwe".

Sesifikile inkathi yokuncintisana yokugoma.Usugcinile ku-GanoHerb organicI-Ganodermalokho kuqinisa ukungatheleleki futhi kulawule ubungqabavu?