I-International Medicinal Mushroom Conference (IMMC) ingeminye yemicimbi emikhulu enethonya embonini yomhlaba wonke yamakhowe adliwayo nawezokwelapha.Ngezinga layo eliphezulu, ubungcweti kanye nokwamazwe ngamazwe, yaziwa ngokuthi “Ama-Olympics embonini yamakhowe adliwayo neyomuthi”.

Le ngqungquthela iyinkundla yososayensi abavela emazweni ahlukene, ezifundeni nasezizukulwaneni ezihlukene ukuze bafunde mayelana nezinto ezintsha ezizuziwe kanye nezindlela ezintsha zamakhowe adliwayo nawezokwelapha.Kungumcimbi omkhulu emkhakheni wamakhowe adliwayo nawezokwelapha emhlabeni.Kusukela iNgqungquthela Yamakhowe Yokwelapha Yomhlaba Wonke yaba seKyiv, inhloko-dolobha yase-Ukraine ngo-2001, le ngqungquthela ibilokhu iba njalo ngemva kweminyaka emibili.

Kusukela mhla zingama-27 kuMandulo kuya kumhla zingama-30, iNgqungquthela Ye-11 Yemithi Yemithi Yamakhowe yabanjelwa eCrowne Plaza Belgrade, inhloko-dolobha yaseSerbia.Njengebhizinisi elihamba phambili embonini ye-organic Reishi yaseChina futhi okuwukuphela kwabaxhasi basekhaya, i-GanoHerb imenywe ukuba ibambe iqhaza kulo mcimbi.

Isigcawu seNkomfa Ye-11 Yamazwe Ngamazwe Yezokwelapha Amakhowe

Le ngqungquthela ihlelwe yi-International Society for Medicinal Mushrooms kanye neNyuvesi yaseBelgrade futhi ihlelwe ngokubambisana yi-Faculty of Agriculture- Belgrade, i-Institute for Biological Research "Siniša Stanković", i-Mycological Society of Serbia, i-European Hygienic Engineering & I-Design Group, i-Faculty of Biology-Belgrade, i-Faculty of Science-Novi Sad, i-Faculty of Natural Science-Kragujevac kanye ne-Faculty of Pharmacy-Belgrade.Ihehe amakhulu ochwepheshe nososayensi emkhakheni wocwaningo lwamakhowe adliwayo nokwelapha abavela eChina, eNyakatho Melika, eYurophu naseSerbia.

Ingqikithi yale ngqungquthela ithi “Isayensi Yamakhowe Yokwelapha: Ukuqamba Okusha, Izinselele kanye Nemibono”, enemibiko eyisihluthulelo, izingqungquthela ezikhethekile, izethulo zamaphosta, nemibukiso yezimboni zamakhowe ezidliwayo nezokwelapha.Ingqungquthela ithatha izinsuku ezi-4.Abameleli bahlangana ndawonye ukuze babike futhi baxoxe ngezindaba zakamuva nezibalulekile zezemfundo emkhakheni wamakhowe adliwayo nawezokwelapha.

Ngomhla zingama-28 kuSepthemba, uDkt. Ahmed Attia Ahmed Abdelmoaty, owalinywa ngokuhlanganyela yi-GanoHerb Postdoctoral Research Station kanye ne-Fujian Medical University, wabelane “ngomphumela we-Senolytic we-triterpenoids complex NT ekhishweI-Ganoderma lucidumemangqamuzaneni omdlavuza wesibindi” ku-inthanethi.

Umdlavuza wesibindi yisimila esiyingozi esivamile.I-Cellular senescence iwuphawu olusha lweCancer olufakwe ekubuyekezweni kwekhava yephephabhuku eliphezulu I-Cancer Discovery ngoJanuwari kulo nyaka (Cancer Discov. 2022; 12: 31-46).Idlala indima ebalulekile ekuphindaphindeni nasekumelaneni ne-chemotherapy komdlavuza okuhlanganisa nomdlavuza wesibindi.

I-Ganoderma lucidum, eyaziwa ngokuthi "ikhambi lomlingo" e-China, isikhunta somuthi esaziwayo kanye nomuthi wendabuko waseShayina.Ivame ukusetshenziselwa ukuvimbela nokwelapha isifo sokusha kwesibindi, izifo zesimiso somzimba sokuzivikela ezifweni kanye nomdlavuza.Izithako ezisebenzayo ze-Ganoderma lucidum ikakhulukazi ama-triterpenoids nama-polysaccharides, anemisebenzi ye-pharmacological ye-hepatoprotection, i-antioxidation, i-antitumor, i-immune regulation kanye ne-antiangiogenesis.Kodwa-ke, akubanga khona umbiko wezincwadi ngomphumela we-senolytic we-Ganoderma lucidum kumaseli omdlavuza we-senescent.

Ngaphansi kokuqondisa kukaSolwazi Jianhua Xu, umqondisi weFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, abacwaningi baseGanoHerb Postdoctoral Research Station basebenzisa i-chemotherapeutic drug doxorubicin (ADR) ukuze babangele umdlavuza wesibindi. bese belashwa ngeI-Ganoderma lucidumi-triterpenoid complex NT ukuze ihlaziye imiphumela yayo ekuvezweni kwamangqamuzana omaka we-senescence wamaseli omdlavuza wesibindi, ingxenye yamaseli e-senescent, i-apoptosis kanye ne-autophagy yamaseli e-senescent kanye ne-senescence-associated secretory phenotype (SASP).

Ucwaningo luthole ukuthi i-Ganoderma lucidum triterpenoid complex NT inganciphisa ingxenye yamangqamuzana omdlavuza wesibindi futhi yenze i-apoptosis yamaseli omdlavuza wesibindi.Ingakwazi ukuqeda amangqamuzana omdlavuza wesibindi we-senescent futhi ivimbele i-SASP kumangqamuzana omdlavuza wesibindi we-senescent ngokuvimbela i-NF-κB, TFEB, P38, ERK kanye ne-mTOR izindlela zokusayina, ikakhulukazi ukuvinjelwa kwe-IL-6, IL-1β ne-IL-1α.

I-Ganoderma lucidumI-triterpenoid complex NT inganqanda ngempumelelo umthelela okhuthazayo wamangqamuzana omdlavuza wesibindi obulalayo ekwandeni kwamangqamuzana omdlavuza wesibindi azungezile ngokuqeda amangqamuzana omdlavuza wesibindi obulalayo futhi angahlanganisa nomphumela we-anti-hepatocellular carcinoma we-sorafenib.Lokhu okutholakele kunokubaluleka okukhulu kanye namathemba angaba khona ocwaningo lwemithi emisha ye-antitumor esekelwe ekuvukeleni kwamaselula.

Indawo yombukiso wenkomfa

I-GanoHerb inikeza ochwepheshe nezifundiswa emhlabeni jikelele iziphuzo ezifanaReishiikhofi.