Amasende ayimbeleko yesidoda, kanti isidoda singamaqhawe enkundleni yempi.Ukulimala kunoma yiluphi uhlangothi kungathinta inzalo.Kodwa-ke, kunezici eziningi empilweni njenge-coronavirus yenoveli eyingozi kuma-testi nesidoda.Amasende nesidoda kungavikelwa kanjani?

Ngo-2021, ithimba lika-Mohammad Nabiuni, uprofesa ohlanganyele woMnyango Wezesayensi Yeselula kanye Nezimo Zemvelo, iNyuvesi yaseKharazmi, e-Iran, lashicilela ucwaningo ku-Tissue and Cell, libonisa ukuthi i-ethanol ekhishwe emzimbeni othela izithelo we-Ganoderma lucidum ingavikela amasende futhi isidoda sezilwane.

Besebenzisa i-lithium carbonate, isidakamizwa somtholampilo se-mania, njengento eyingozi, abacwaningi bondle amagundane amadala anempilo ama-30 mg/kg we-lithium carbonate (iqembu le-lithium carbonate) nsuku zonke, futhi baphakela namanye amagundane amadala anempilo engu-75 mg/kg I-Ganoderma lucidum ethanol extract (umthamo ophansi weqembu le-Reishi + lithium carbonate) nsuku zonke noma u-100 mg/kg we-Ganoderma lucidum ethanol extract (umthamo ophezulu weqembu le-Reishi + lithium carbonate) nsuku zonke.Futhi baqhathanisa izicubu zomhlola zeqembu ngalinye lamagundane ngemva kwezinsuku ezingama-35.

I-Ganoderma lucidum isiza ukuvikela ikhono le-spermatogenesis lamasende.

U-95% wevolumu yamasende atholakala ku-scrotum uhlala "amashubhu akhiqiza isidoda", lezi zigaxa zamashubhu azacile agobile, aziwa nangokuthi "ama-seminiferous tubules", yilapho kukhiqizwa khona isidoda.

Isimo esijwayelekile kufanele sibe njengoba sikhonjisiwe esithombeni esingezansi.I-lumen yamashubhu e-seminiferous izogcwala isidoda esivuthiwe, futhi "i-spermogenic epithelium" eyenza udonga lwamashubhu "inamaseli e-spermogenic" ezigabeni ezihlukahlukene zokuthuthuka.Phakathi kwamashubhu e-seminiferous, kukhona "i-interstitial tissue of the testis" ephelele.I-testosterone ekhiqizwe amangqamuzana alesi zicubu (ama-interstitial cell) ayisekeli nje kuphela ukusebenza kocansi kodwa futhi idala indawo evumela ukukhula kwesidoda.

Izicubu zamasende zamagundane anempilo kulolu cwaningo zibonise amandla amakhulu ashiwo ngenhla.Ngokuphambene, izicubu zesende zamagundane eqenjini le-lithium carbonate zibonise i-atrophy ye-seminiferous epithelium, ukufa kwe-spermatogonia, isidoda esincane esivuthiwe kumashubhu e-seminiferous, kanye nokushwabana kwezicubu ze-interstitial testis.Kodwa-ke, isimo esinjalo esibuhlungu asenzekanga kulawo magundane eqenjini le-lithium carbonate elivikelwe yi-Ganoderma lucidum.
Izicubu zamasende "zezinga eliphezulu leqembu le-Reishi + lithium carbonate" lalicishe lifane nelamagundane anempilo.Akukhona nje ukuthi i-seminiferous epithelium yayingaguquki, kodwa amashubhu e-seminiferous nawo ayegcwele isidoda esivuthiwe.

Nakuba amashubhu e-seminiferous "we-dose ephansi yeqembu le-Reishi + lithium carbonate" abonisa ukuwohloka noma ukuwohloka okuncane kuya kokulinganisela, amashubhu amaningi e-seminiferous ayesenamandla ukusuka ku-spermatogonia kuya esidodeni esivuthiwe (i-spermatogonia → ama-spermatocyte ayinhloko → ama-spermatocyte esibili → ama-spermatid) .

Ngaphezu kwalokho, ukuvezwa kwe-pro-apoptotic gene BAX, ekhombisa i-apoptosis, kuzicubu ze-testis zamagundane kuphinde kwanda kakhulu ngenxa yomonakalo we-oxidative obangelwa i-lithium carbonate, kodwa lokhu kwanda kungase futhi kususwe ukusetshenziswa okuqhubekayo kwe-Ganoderma. lucidum.

I-Ganoderma lucidum isiza ukugcina inani lesidoda kanye nekhwalithi.

Abacwaningi baphinde bahlaziya inani kanye nekhwalithi (ukusinda, ukuhamba, isivinini sokubhukuda) kwesidoda segundane.Isidoda lapha siphuma “ku-epididymis” phakathi kwe-testis ne-vas deferens.Ngemva kokuba isidoda kwakheka kumasende, sizophushwa lapha ukuze siqhubeke sikhule sibe isidoda esikwazi ukuhamba kwangempela kanye nekhono lokuvundisa silinde ukuqhanyelwa.Ngakho-ke, indawo empofu ye-epididymal izokwenza kube nzima ukuthi isidoda sibonise amandla abo.

Isibalo esingezansi sibonisa ukuthi i-lithium carbonate ibangela ukulimala okusobala kwe-oxidative kuzicubu ze-epididymal futhi inciphisa ukubalwa kwesidoda, ukusinda, ukuhambahamba kanye nesivinini sokubhukuda.Kodwa uma kukhona ukuvikeleka ku-Ganoderma lucidum ngesikhathi esifanayo, izinga lokunciphisa isidoda kanye nokuba buthakathaka liyobe lilinganiselwe kakhulu noma lingathinteki ngokuphelele.

Imfihlo ye-Ganoderma lucidum yokuvikela ubudoda bamadoda ilele “ku-antioxidation”.

I-ethanolic ekhishwe imizimba ye-Ganoderma lucidum fruiting esetshenziswe ocwaningweni iqukethe ama-polyphenols (20.9 mg/mL), ama-triterpenoids (0.0058 mg/mL), ama-polysaccharides (0.08 mg/mL), umsebenzi ophelele we-antioxidant noma ikhono lokuqothula ama-radicals mahhala e-DPPH (88.86) %).Lo msebenzi omuhle kakhulu we-antioxidant ubhekwa abacwaningi njengesinye sezizathu eziyinhloko ze-Ganoderma lucidum ethanol ekhishwe ukuvikela izicubu ze-testicular kanye ne-epididymal nokugcina i-spermatogenesis kanye ne-sperm motility.

Empilweni yangempela, sivame ukuzwa ukuthi abesifazane abangenayo inzalo isikhathi eside bakhulelwa ngemva kokuthatha i-Ganoderma lucidum isikhathi esithile, okusho ukuthi i-Ganoderma lucidum ingenza okuthile ngesibeletho sabesifazane, ama-ovari noma uhlelo lwe-endocrine;manje lolu cwaningo lubonisa ukuthi i-Ganoderma lucidum ingazuza futhi isimiso sokuzala samadoda.

Ngosizo lwe-Ganoderma lucidum, uma umbhangqwana uzama ukukhiqiza kabusha inzalo yabo, nakanjani uzothola umphumela ophindwe kabili ngesigamu somzamo.Uma bengacabangi ukuzala kodwa baphishekela injabulo yokuvumelana, inhlansi yothando ngosizo lwe-Ganoderma lucidum kufanele ibe yinhle kakhulu.

[Qaphela] Inani le-P leqembu le-lithium carbonate emashadini lisuka ekuqhathanisweni neqembu elinempilo, futhi inani elingu-P lamaqembu amabili e-Ganoderma lucidum lisuka ekuqhathanisweni neqembu le-lithium carbonate, * P <0.05, ** *P <0.001.Inani elincane, umehluko ngokubaluleka mkhulu.

Ireferensi
Ghazal Ghajari, et al.Ukuhlangana phakathi kobuthi be-testicular obubangelwa i-Li2Co3 kanye nomthelela ovikelayo we-Ganoderma lucidum: Ukuguqulwa kokubonakaliswa kwezakhi zofuzo ze-Bax & c-Kit.Iseli Yezicubu.2021 Okthoba;72:101552.doi: 10.1016/j.tice.2021.101552.

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