Nangona kukho utshintsho oluninzi ehlabathini, into engatshintshiyo kukuba umhlaza wemiphunga useyingxaki enkulu kwimpilo yabantu;nangona ukuqaliswa ngokuphindaphindiweyo kwamachiza e-anticancer, amachiza e-chemotherapy yendabuko aseyinto embi eyimfuneko kwiimeko ezininzi.

Nangona kunjalo, ukuba iiseli eziqhelekileyo azikhuselwanga kakuhle, kungakhathaliseki ukuba i-chemotherapy inamandla kangakanani, kuya kuba nzima kwisigulana ukuyithwala.

Indlela yokuzikhusela ngexesha le-chemotherapy?Thatha isiphumo se-chemotherapy kangangoko kunokwenzeka kwaye uphelise ubuthi be-chemotherapy?Indibaniselwano neI-Ganoderma lucidumi-polysaccharides ngexesha le-chemotherapy lukhetho olufanele ukuqwalaselwa ngokunzulu.

Uphando olupapashwe kwimiba kaDisemba 2021 ye "Ijenali yeHlabathi yeBiological Macromolecules" nguNjingalwazi onguNjingalwazi uTung-Yi Lin et al.ukusuka kwiziko loNyango lweSintu kwiYunivesithi yeSizwe yaseYang Ming Chiao Tung eTaiwan ibonakalise ngovavanyo lweeseli kunye nezilwanyana ukubaI-WSG (iPolysaccharide eNyibilikayo ngaManzi evela kwiI-Ganoderma lucidum)ayinakuphucula kuphela impembelelo yokuthintela ichiza lechemotherapy cisplatin kwilung adenocarcinoma kodwa ikwakhusela iiseli zokhuselo lomzimba kunye neeseli eziqhelekileyo kwaye yonyuse kakhulu izinga lokusinda kwezilwanyana zovavanyo. 

Uvavanyo lweeseli lubonise ukuba indibaniselwano ye-WSG kunye ne-cisplatin yonyuse ukusebenza kwe-cisplatin kwaye yanciphisa ubutyhefu be-cisplatin.

Abaphandi badibanise ulawulo lwe-WSG kunye ne-cisplatin ukujonga iziphumo zabo kwiiseli ze-lung adenocarcinoma kunye neeseli eziqhelekileyo ze-vitro.

Kwafunyaniswa ukuba ingaba ichasene neeseli zemiphunga ye-adenocarcinoma yabantu okanye iiseli zempuku ze-adenocarcinoma, i-WSG (i-Water Soluble Polysaccharide ephumaI-Ganoderma lucidum) inokuthi "iphucule" ukubulawa kwe-cisplatin kwiiseli zomhlaza (oko kukuthi, ukukhuthaza i-apoptosis yeeseli zomhlaza);ngokuchaseneyo, nokuba ichasene neeseli zezicubu zemiphunga eziqhelekileyo okanye ii-macrophages zempuku, i-WSG ino "ukunciphisa" umonakalo we-cisplatin kwiiseli eziqhelekileyo.

I-WSG iyodwa ayinabungozi kwiiseli zomhlaza kunye neeseli eziqhelekileyo ngelixa i-cisplatin iyodwa inokonakalisa zombini iiseli zomhlaza kunye neeseli eziqhelekileyo.Nangona kunjalo, ulawulo oludibeneyo lwe-WSG kunye ne-cisplatin linokunciphisa izinga lokusinda kweeseli zomhlaza kwaye zizabalazele indawo engaphezulu yokusinda kwiiseli eziqhelekileyo, ebonisa ukuba i-WSG inefuthe lokunyusa ukusebenza kwe-cisplatin kunye nokunciphisa ubuthi be-cisplatin.

Ukusebenza kweeseli zemiphunga ye-adenocarcinoma, i-WSG kunye ne-cisplatin zikhuliswe i-24h.

Ukusebenza kweseli kweeseli eziqhelekileyo ezikhuliswe nge-WSG okanye i-cisplatin ye-24h

Ukusebenza kweseli kweeseli eziqhelekileyo, i-WSG kunye ne-cisplatin co-cultured for 24h

Uvavanyo lwezilwanyana lubonisa ukuba ulawulo oludibeneyo lwe-WSG kunye ne-cisplatin luthoba ukukhula kwethumba.

Abaphandi baphinda bafakela umgca weseli yempuku ye-adenocarcinoma kwizicubu ezingaphantsi kweempuku zovavanyo.Phantsi kwemeko yokuba amajoni omzimba abandakanyeka kumlo ochasene nomhlaza, abaphandi baqaphela isiphumo se-WSG engena emzimbeni kunyango lwe-cisplatin.Emva kweentsuku ezingama-21 zovavanyo, abaphandi bafumanisa ukuba i-WSG iyodwa okanye i-cisplatin iyodwa inokwenza ukuba ithumba likhule kancinci kwaye libe lincinci, kwaye i-tumor inhibitory effect ye-WSG yayingekho ngaphantsi kwe-cisplatin, kodwa isiphumo esidibeneyo se-WSG (Amanzi anyibilikayo Ipolysaccharide evela kuyoI-Ganoderma lucidum) kwaye i-cisplatin yeyona nto ingcono.

Isiphumo esithintelayo se-WSG, i-cisplatin okanye zombini ekukhuleni kwe-lung adenocarcinoma

Uvavanyo lwezilwanyana lubonisa ukuba "i-WSG + cisplatin" iyanciphisa izehlo zethumba kwaye iphucule ukusebenza.

Abaphandi baye benza olunye ulingo lwezilwanyana, betofa umgca weseli ye-adenocarcinoma ukusuka kumthambo womsila wempuku, emva koko bayinyange nge-WSG, cisplatin okanye zombini, kwaye bajonga inani lamathumba okanye amaqhuqhuva akhule emiphungeni kunye nokusinda. yeempuku emva kweentsuku ezingama-21.Baye bafumanisa ukuba i-WSG, i-cisplatin okanye ulawulo oludityanisiweyo lwazo zombini lunokuthintela ukwakheka kwamathumba okanye amaqhuqhuva, kwaye lunokwandisa ubomi beempuku ze-lung adenocarcinoma, kodwa iqela elisebenza kakuhle lalingalindelekanga iimpuku ze-adenocarcinoma zemiphunga ziphathwe nge-WSG yodwa.I-WSG (iPolysaccharide eNyibilikayo ngaManzi evela kwiI-Ganoderma lucidum) idlala ngokucacileyo indima ebalulekileyo ekuphuculeni ukusebenza komzimba kunye nokukhusela iiseli eziqhelekileyo.

Ukuvinjelwa kokukhula kwamathumba okanye amaqhuqhuva emiphungeni yi-WSG, cisplatin okanye zombini kunye nefuthe lazo kubomi bokuphila.

I-WSG ilungile ngokulinganayo ekukhuselweni nasekukhuseleni kwi-anti-cancer.

Isiphumo se-WSG kuthintelo lwe-tumor kunye nokukhuselwa kobomi kuvavanyo lwezilwanyana alukho ngaphantsi okanye lungcono kune-cisplatin yodwa okanye idityaniswe ne-cisplatin, eyona nto ibangelwe kukuba i-WSG (i-Water Soluble Polysaccharide ethathwe kuyo).I-Ganoderma lucidum) iyakwazi ukucinezela iiseli zomhlaza nje ukuba zivele.

Ebusweni iiseli zomhlaza ezingekakhuli kwaye zenze amathumba, ukuba nje sinokusebenza ngokukhawuleza ukuphucula ukusebenza komzimba kunye nokukhusela iiseli eziqhelekileyo, kusoloko kulula ukunciphisa umonakalo weeseli zomhlaza.

Ke ngoko, ezi ziphumo zophando zingasentla aziboneleli kuphela ngesiseko sesalathiso sokuphucula ukusebenza kunye nokunciphisa ubutyhefu bamachiza echemotherapy kodwa zikwangqina ukuba ukusetyenziswa kwe-WSG ngexesha lechemotherapy ngokuqinisekileyo kukudibanisa kunokuba kuthatyathwe okanye kuphazamiseke, kwaye kukwasikhumbuza ngokubaluleka kwaye ukubanakho ukuthatha amanyathelo okukhusela kwindawo yokuqala.

Kuphela kolu phononongo, i-WSG yanikezelwa kwizilwanyana zokulinga ngenaliti ye-intraperitoneal.Ukusebenza kakuhle kwe-peritoneal absorption kwi-intestinal tract ikhawuleza kunokungena ngomlomo, kwaye idosi ye-intraperitoneal nayo ingaphantsi kwedosi efunwa ngulawulo lomlomo.Ke ngoko, ingakanani idosi ye-WSG ekufuneka ithathwe ngomlomo ukufumana isiphumo esifanayo nesitofu se-intraperitoneal ifanele ukuxoxwa ngakumbi ngabaphandi.

[Umthombo] Wei-Lun Qiu, et al.I-WSG, i-Glucose-Rich Polysaccharide esukaI-Ganoderma lucidum, Idityaniswe neCisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.Iipolymers (Basel).2021;13(24):4353.

ISIPHELO

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