Ubhubhani we-coronavirus wenoveli utshabalalise uluntu iminyaka emithathu ukuza kuthi ga ngoku.Ukusukela ngoDisemba ka-2022, uvavanyo oluqhelekileyo lwe-nucleic acid luye lwarhoxiswa kwiindawo ezininzi kulo lonke elase-China, kwaye isatifikethi sokuvavanywa kwe-nucleic acid engalunganga se-COVID-19 asisayi kuphinda sijongwe.I-China ingene kwixesha lokubakho kunye nobhubhane.Ukujongana nencopho enokwenzeka yosulelo, indlela yokuphucula ukungakhuseleki kwaye ube ngumntu wokuqala onoxanduva lwempilo yakho ibe sisihloko esixhalabisa kakhulu kuluntu lonke.

Njengoko izibonelelo zamayeza emveli aseTshayina ekuthinteleni nasekulawuleni ubhubhane ziye zavela ngakumbi, "I-Ganoderma lucidum", enempembelelo yokuphucula ukuzivikela kunye nokugcina ukulingana komsebenzi wonke, uye wasebenza ngokugqwesileyo ekuthinteleni nasekulawuleni ubhubhane.

Ngoko, yenzaI-Ganoderma lucidumNgaba kukho nasiphi na isiphumo sokuthintela kwinoveli coronavirus?Ngaba izigulana ezine-COVID-19 zingatyaI-Ganoderma lucidumukuba nefuthe elihle emzimbeni?Iziphumo zophando ezininzi zamva nje zisinika ubungqina obulungileyo.

Ngo-Epreli 2020, ijenali yezemfundo yamazwe ngamazweIimolekyuliyapapasha “Ii-Natural Bioactive Compounds ezisuka kwi-Fungi njengabaKhona abaKhona kwi-Protease Inhibitors kunye ne-Immunomodulators ukuba bafake isicelo se-Coronaviruses”.

Eli phepha liphonononga ukufunyanwa kunye nenkqubela phambili yophando lweekhompawundi zendalo ezisebenzayo zomngundo ekuthinteleni intsholongwane kaGawulayo (human immunodeficiency virus) (HIV) protease.Iphakamisa ukuba iikhompawundi ezisebenzayo zefungi, ngakumbiI-Ganoderma lucidum(i-triterpenoids, iipolysaccharides kunye neeproteni ezincinci zemolekyuli) zidlala indima ebalulekileyo ekuthinteleni i-human immunodeficiency viral (HIV) protease.

Olu phononongo lubonelela ngomntu onokuba ngamachiza kuthintelo kunye nonyango lwe-coronavirus, enokuthi isetyenziswe kwixa elizayo ukunqanda kunye nokunyanga ii-coronavirus, ngakumbi kuthintelo kunye nonyango losulelo lwe-coronavirus entsha.

Ngo-2021, "Iinkqubo zeNational Academy of Sciences (PNAS) 2021 Vol.118 No.5″ yapapasha inqaku elithi "Ukuchongwa kweeNhibitors zeNoveli ye-Coronavirus yoSulelo oluvela kuMachiza aLudwe kunye namaYeza eHerbal".Uphononongo lufumanise ukubaI-Ganoderma lucidumisicatshulwa samanzi sinokuluthintela kakhulu usulelo lwenoveli coronavirus (SARS-Cov-2) zombini kwi-vivo kunye ne-vitro.

Amayeza aseShayina amayeza e-herbal isicatshulwa samanzi (1.0 g / 20 mL, 5%) kunyeI-Ganoderma lucidumi-polysaccharide RF3 (0.25 mg/mL, 0.025%).IC50=isiqingatha sokuthintela (intsholongwane) ithamo;CC50=isiqingatha sedosi eyityhefu

Iziphumo ziyayingqina loo ntoI-Ganoderma lucidumi-polysaccharide RF3 (2μg/ml) inefuthe elibalulekileyo lokulwa nentsholongwane kwi-SARS-Cov-2 ekhuliswe kwi-vitro, kwaye isenomsebenzi othintelayo xa ihlanjululwe kumaxesha angama-1280.Kodwa ayinayo ityhefu kwintsholongwane ebamba iiseli zeVero E6.

(A) Abaphandi baye baqaphela iziphumo ezichasene ne-sars-cov-2 zamachiza kunye nezicatshulwa kwii-hamsters.Ngomhla we-0, ii-hamsters zosulelwa ngokufakwa kwe-intranasal ye-SARS-CoV-2.Emva koko, i-hamster yayilawulwa ngomlomo iziyobisi (30mg / kg / d) kunye nesicatshulwa semveli saseTshayina (200mg / kg / d), kabini / d, kunye nomthamo wentsholongwane kwimiphunga ye-hamster yalinganiswa emva kweentsuku ze-3 ( n = 5), * P <0.05 ;* * P <0.005 (B) Ukutshintsha kwesisindo somzimba emva kokunyanga kwe-3-d, N = 5 kwiqela lovavanyo, N = 6 kwiqela lolawulo.Iziphumo zangqina ukuba xa kuthelekiswa neqela lolawulo losulelo, ulawulo lomlomo lweI-Ganoderma lucidumi-polysaccharide RF3 inokunciphisa kakhulu umthamo wentsholongwane egazini (umxholo) kwimiphunga yeehamster ezosulelwe yintsholongwane ye-SARS-Cov-2, kwaye izilwanyana azizange zinciphise ubunzima ngexesha lovavanyo.Uvavanyo lwe-in vivo kunye ne-vitro antiviral luye lwangqina okoI-Ganoderma lucidumi-polysaccharide RF3 ithintele kakhulu usulelo lwe-SARS-Cov-2.

NgoFebruwari ka-2020, uNjingalwazi uSun Guifan, usekela-sihlalo we-Precision Nutrition Professional Committee ye-China Nutrition and Health Food Association, kunye ne-Institute of Preventive Medicine yeYunivesithi yezoNyango yase-China, bakhupha esidlangalaleni inqaku elithi "Inqaku lesibini elidumileyo lesayensi malunga noncedo oluchanekileyo. kuthintelo kunye nonyango lwenoveli yosulelo lwe-coronavirus ngokwemiqathango yesondlo-umsebenzi wezongezo zesondlo”, yabhengezwa kuluntu ngeentlobo ezili-12 zezongezo zesondlo ezinokunceda ukuthintela kunye nokunyanga usulelo lwe-coronavirus entsha, kubandakanyaI-Ganoderma lucidum, iyeza lesintu laseTshayina!

Kwinqaku, uNjingalwazi Sun wabonisa ngokucacileyo ukubaI-Ganoderma lucidumine-immune stimulating effect, enokuthi ichaphazele ngokuthe ngqo amandla ayo okulwa nosulelo lwebhaktheriya kunye nentsholongwane.Uphononongo lweeseli zeLebhu lubonise ukuba isicatshulwa seReishi sinokunqanda okanye sicothise ukukhula kwentsholongwane yomkhuhlane, i-HIV, i-hepatitis B kunye nezinye iintsholongwane ezininzi, ukubuyisela ukwehla okunxulumene neminyaka ekusebenzeni kwamajoni omzimba.

UNjingalwazi uZhi-Bin Lin weZiko leSayensi yezeMpilo yeYunivesithi yasePeking, oye wagxila kuphando lwe-pharmacologicalI-Ganoderma lucidumngaphezulu kweminyaka engama-50, yazisa isiphumo se-antiviral kunye nenkqubo yeI-Ganoderma lucidumkwinqaku elithi “Antiviral Effect ofI-Ganoderma lucidum” epapashwe ekupheleni kuka-2020, ebonisa ukubaI-Ganoderma lucidum, ngakumbi i-triterpenes equlethwe kuyoI-Ganoderma lucidum, zineempembelelo ezithintelayo kwiintsholongwane ezahlukeneyo.

Unjingalwazi uZhi-Bin Lin wahlalutya kwangaphambili indlela yempembelelo ye-antiviral yeI-Ganoderma lucidum, okubandakanya ukuthintela i-adsorption okanye ukungena kweentsholongwane kwiiseli, ukuvimbela i-virus ucoating, ukuvimbela umsebenzi we-enzymes (njenge-reverse transcriptase kunye ne-protease) efunekayo kwi-virus synthesis kwiiseli, kunye nokuthintela i-viral DNA okanye i-RNA ukuphindaphinda kodwaI-Ganoderma lucidumayinayo ityhefu ekusingatheni iiseli kwaye inefuthe le-synergistic lidityaniswe neziyobisi ezaziwayo ze-antiviral.

Eli nqaku liphinde labonisa ukuba ukusebenza kweklinikhi yeI-Ganoderma lucidumkwizifo zentsholongwane inokuthi inxulumene ikakhulu nesiphumo solawulo lomzimba weI-Ganoderma lucidum, i-anti-oxidation kunye nesiphumo sasimahla se-radical scavengingI-Ganoderma lucidum, kunye nesiphumo sokukhuselaI-Ganoderma lucidumkumalungu kunye nezicubu.

Uphando lwangoku lubonisa ukubaI-Ganoderma lucidumutyebile kwintlaninge yezithako ezisebenzayo, ezithi "isithunywa" sokuqinisa ukhuselo lomzimba.

Ngokuqhelekileyo, okukhona umxholo wezithako ezisebenzayo, ungcono umphumo wokuphucula ukugonywa.

Kwangoko ngo-2017, i-GanoHerb kunye ne-Fujian yePhondo yeZiko loLawulo lweSifo kunye noThintelo ngokudibeneyo yasungula iprojekthi yophando "Isiphumo seGanoderma LucidumIigranules kuMsebenzi waMazimba”.Iimpuku zahlulwa zangamaqela amahlanu, kwaye zanikwa iidosi ezahlukeneyoI-Ganoderma lucidumiigranules (nguGanoHerb Technology (Fujian) Corporation).

Ngokuthelekisa iqela ngalinye ledosi yesampulu kunye neqela lolawulo, kwafunyaniswa ukuba: ①Iqela lesampulu yedosi ephezulu liphucule kakhulu isakhono sokwanda kwe-lymphocyte ye-mouse spleen eyenziwa yi-ConA kunye ne-hypersensitivity yohlobo lokulibaziseka olubangelwa yi-DNFB;②Amaqela aphakathi kunye ne-high-dose aphucula kakhulu amandla okwenza i-antibody, iqela ledosi ephezulu liye lanyusa kakhulu inqanaba le-serum hemolysin kwiimpuku;③Iqela lesampulu yedosi ephezulu yonyuse kakhulu umsebenzi weeseli ze-NK kwiimpuku.

Isiphelo esithathwe kuvavanyo kukuba iigranules zeGanoderma zenziwe ngeI-Ganoderma lucidumkhupha kunyeGanoderma sinenseIsicatshulwa sinomsebenzi wokuphucula ukhuseleko.Njengenkampani ekhokelayo egxile kumzi mveliso wezempilo weGanoderma, ukusukela oko kwaqhambuka lo bhubhani ngo-2020, iGanoHerb inikezele nge-9.126 yezigidi zeeyuan ngemali kunye nezinto ezibandakanya.I-Ganoderma lucidumioli ye-spore,I-Ganoderma lucidumspore powder kunyeI-Ganoderma lucidumisicatshulwa sokunceda abasebenzi bezonyango abaphambili kunye nabanye abasebenzi baphucule ukhuseleko lwabo kunye nokwakha umgca wokhuseleko osempilweni kunye.Kungenxa yolu xanduva kunye nokuzibophelela ekuzameni ukulwa nobhubhane owathi ngo-2021, iGanoHerb Technology (Fujian) Corporation., icandelo leGanoHerb Group, yanikezelwa "kwiPhondo leFujian Advanced Private Enterprise ekulweni neNovel Coronary Pneumonia. Indyikitya yesifo esisulelayo".

Ixesha lokhuphiswano lokugonyeka lifikile.Ngaba ugcinile kwi-GanoHerb organicI-Ganodermaoko komeleza ukhuseleko kunye nokulawula amandla?