Amasende ngumbeleko wedlozi, kwaye amadlozi ngamagorha edabi.Ukwenzakala kulo naliphi na icala kunokuchaphazela ukuchuma.Nangona kunjalo, zininzi izinto ebomini ezifana ne-coronavirus entsha eyingozi kwiimvavanyo kunye nesidoda.Angakhuselwa njani amasende kunye nedlozi?

Ngo-2021, iqela lika-Mohammad Nabiuni, uprofesa onxulumene neSebe le-Cellular kunye ne-Molecular Biology, iYunivesithi yaseKharazmi, e-Iran, yapapasha isifundo kwi-Tissue kunye neCell, ebonisa ukuba isicatshulwa se-ethanol esivela kumzimba weziqhamo weGanoderma lucidum unokukhusela iistes amadlozi ezilwanyana.

Ukusebenzisa i-lithium carbonate, iyeza leklinikhi ye-mania, njengento eyingozi, abaphandi bondla iimpuku zabantu abadala abanempilo 30 mg / kg ye-lithium carbonate (iqela le-lithium carbonate) yonke imihla, kwaye bondla ezinye zeempuku zabantu abadala abaphilileyo 75 mg / kg I-Ganoderma lucidum ethanol extract (i-dose ephantsi ye-Reishi + lithium carbonate iqela) yonke imihla okanye i-100 mg / kg ye-Ganoderma lucidum ethanol extract (i-dose ephezulu ye-Reishi + lithium carbonate iqela) yonke imihla.Kwaye bathelekisa izicubu ze-testis zeqela ngalinye leempuku emva kweentsuku ezingama-35.

I-Ganoderma lucidum inceda ukukhusela amandla e-spermatogenesis yamasende.

I-95% yomthamo wamatyhalarha abekwe kwisingxobo samatyhalarha kuhlala “zii-tubules ezivelisa amadlozi”, ezi tyhubhu ezibhityileyo ezigobileyo, ezikwabizwa ngokuba “zii-seminiferous tubules”, kulapho kuveliswa khona amadlozi.

Imeko eqhelekileyo kufuneka ibe njengoko kubonisiwe kulo mfanekiso ungezantsi.I-lumen yee-tubules ze-seminiferous iya kuzaliswa ngamadlozi avuthiweyo, kwaye "i-spermogenic epithelium" eyenza udonga lwetyhubhu ine "iiseli ze-spermogenic" kwizigaba ezahlukeneyo zophuhliso.Phakathi kwee-tubules ze-seminiferous, kukho "i-interstitial tissue of the testis" epheleleyo.I-testosterone efihliweyo ngamaseli ale zicubu (iiseli ze-interstitial) azixhasi nje kuphela umsebenzi wesondo kodwa zenza indawo ekhuthaza ukuphuhliswa kwesidoda.

Ithishu yamatyhalarha yeempuku ezisempilweni kolu phononongo ibonise obu bunzima bukhankanywe ngasentla.Ngokwahlukileyo koko, izicubu zamatyhalarha zeempuku kwiqela le-lithium carbonate zibonise i-atrophy ye-seminiferous epithelium, ukufa kwe-spermatogonia, amadlozi ambalwa aqolileyo kwii-tubules ze-seminiferous, kunye nokushwabana kwe-interstitial tissue of the testis.Nangona kunjalo, imeko enjalo ebuhlungu ayizange yenzeke kwezo mpuku kwiqela le-lithium carbonate elikhuselwe yiGanoderma lucidum.
Izicubu ze-testicular "ye-dose ephezulu ye-Reishi + lithium carbonate iqela" yayiphantse yafana neempuku eziphilileyo.I-epithelium ye-seminiferous yayingaphelelanga nje kuphela, kodwa ii-tubules ze-seminiferous nazo zazizele ngamadlozi aqolileyo.

Nangona i-seminiferous tubules "yedosi ephantsi yeReishi + lithium carbonate group" ibonise i-atrophy ephakathi ukuya kwimodareyitha okanye ukuwohloka, ininzi ye-seminiferous tubules yayisenamandla ukusuka kwi-spermatogonia ukuya kwisidoda esivuthiweyo (i-spermatogonia → i-spermatocyte yokuqala → i-spermatocyte yesibini → i-spermatids) .

Ukongeza, ukubonakaliswa kwe-pro-apoptotic gene BAX, ebonisa i-apoptosis, kwi-testis tissue yeempuku nayo yonyuka kakhulu ngenxa yomonakalo we-oxidative obangelwa yi-lithium carbonate, kodwa oku kunyuka kunokupheliswa ngokusetyenziswa okuqhubekayo kweGanoderma. lucidum.

I-Ganoderma lucidum inceda ukugcina inani lamadlozi kunye nomgangatho.

Abaphandi baphinde bahlalutya ukubala kunye nomgangatho (ukusinda, ukuhamba, isantya sokubhukuda) kwembewu yegundane.Idlozi apha liphuma kwi “epididymis” phakathi kwe testis kunye ne vas deferens.Emva kokuba idlozi lenziwe kumatyhalarha, liza kutyhalelwa apha ukuze liqhubeke likhula libe sisidoda esinentshukumo yokwenyani kunye nobuchule bokuchumisa silindele ukuphuma.Ngoko ke, imeko ye-epididymal embi iya kwenza kube nzima ukuba isidoda sibonise amandla abo.

Lo mzobo ungezantsi ubonisa ukuba i-lithium carbonate ibangela umonakalo ocacileyo we-oxidative kwizicubu ze-epididymal kunye nokunciphisa inani lamadlozi, ukusinda, ukuhamba kunye nesantya sokubhukuda.Kodwa ukuba kukho ukukhuselwa kwi-Ganoderma lucidum ngexesha elifanayo, iqondo lokunciphisa isidoda kunye nobuthathaka liya kuba buthathaka kakhulu okanye lingachaphazeleki ngokupheleleyo.

Imfihlo yeGanoderma lucidum yokukhusela ubudoda bamadoda ilele “kwi-antioxidation”.

Isicatshulwa se-ethanolic semizimba yeziqhamo ye-Ganoderma lucidum esetyenziswe kuvavanyo iqulethe iipolyphenols (20.9 mg/mL), i-triterpenoids (0.0058 mg/mL), i-polysaccharides (0.08 mg/mL), umsebenzi we-antioxidant iyonke okanye ukukwazi ukutshabalalisa i-DPPH i-radicals yamahhala (88.86) %).Lo msebenzi ubalaseleyo we-antioxidant uthathwa ngabaphandi ukuba sesinye sezizathu eziphambili ze-Ganoderma lucidum ethanol extract ukukhusela izicubu ze-testicular kunye ne-epididymal kunye nokugcina i-spermatogenesis kunye ne-sperm motility.

Ubomi bokwenyani, sihlala siva ukuba abafazi bexesha elide abangenanzala bakhulelwe emva kokuthatha i-Ganoderma lucidum ixesha elithile, oku kuthetha ukuba i-Ganoderma lucidum inokwenza into ethile kwi-uterus yabasetyhini, ama-ovari okanye inkqubo ye-endocrine;ngoku olu phononongo lubonisa ukuba iGanoderma lucidum inokunceda inkqubo yokuzala yamadoda.

Ngoncedo lweGanoderma lucidum, ukuba isibini sizama ukuvelisa inzala yabo, ngokuqinisekileyo baya kufumana umphumo ophindwe kabini ngesiqingatha somzamo.Ukuba abathatheli ngqalelo ukuzala kodwa basukela ulonwabo kuphela, intlantsi yothando ngoncedo lweGanoderma lucidum kufuneka ibentle ngakumbi.

[Qaphela] Ixabiso le-P leqela le-lithium carbonate kwiitshathi lisuka ekuthelekisweni neqela eliphilileyo, kwaye ixabiso le-P lamaqela amabini e-Ganoderma lucidum livela ekuthelekisweni neqela le-lithium carbonate, * P <0.05, ** * P <0.001.Ixabiso elincinci, kokukhona umahluko omkhulu ngokubaluleka.

Isalathiso
Ghazal Ghajari, et al.Unxulumano phakathi kobutyhalarha betyhalarha obubangelwa yi-Li2Co3 kunye nefuthe elikhuselayo le-Ganoderma lucidum: Ukuguqulwa kwe-Bax kunye ne-c-Kit genes expression.Iseli yeTishu.2021 Okt;72:101552.doi: 10.1016/j.tice.2021.101552.

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