Nubwo hari impinduka nyinshi ku isi, ikidahinduka ni uko kanseri y'ibihaha ikiri ikibazo gikomeye ku buzima bw'abantu;nubwo hashyizweho inshuro nyinshi imiti igabanya ubukana, imiti gakondo ya chimiotherapie iracyari ikibi gikenewe muri byinshi.

Ariko, niba selile zisanzwe zitarinzwe neza, nubwo chimiotherapie yaba ikomeye gute, bizagora umurwayi kuyihanganira.

Nigute wakwirinda mugihe cya chimiotherapie?Fata ingaruka za chimiotherapie bishoboka kandi ukureho uburozi bwa chimiotherapie?Gukomatanya hamweGanoderma lucidumpolysaccharide mugihe cya chimiotherapie nuburyo bukwiye kwitabwaho cyane.

Ubushakashatsi bwasohotse mu nomero yo mu Kuboza 2021 y '“Ikinyamakuru mpuzamahanga cya Biologiya Macromolecules” cyanditswe na Porofeseri wungirije Tung-Yi Lin n'abandi.wo mu kigo cy’ubuvuzi gakondo cya kaminuza ya Yang Ming Chiao Tung muri Tayiwani yerekanye binyuze mu bushakashatsi bw’utugari n’inyamaswa koWSG (Amazi meza ya Polysaccharide akomokaGanoderma lucidum)ntishobora gusa kunoza ingaruka zo kubuza imiti ya chimiotherapie imiti ya cisplatine kumihaha adenocarcinoma ariko kandi irinda ingirabuzimafatizo hamwe ningirabuzimafatizo zisanzwe kandi byongera cyane ubuzima bwinyamaswa zigerageza. 

Ubushakashatsi bwakorewe mu kagari bwerekanye ko guhuza WSG na cisplatine byongereye imbaraga za cisplatine kandi bigabanya uburozi bwa cisplatine.

Abashakashatsi bahujije ubuyobozi bwa WSG na cisplatine kugira ngo barebe ingaruka zabyo ku ngirabuzimafatizo ya adenocarcinoma na selile zisanzwe muri vitro.

Byagaragaye ko yaba irwanya ibihaha byabantu adenocarcinoma cyangwa ibihaha byimbeba adenocarcinoma, WSG (Amazi ya Soluble Polysaccharide yakomotse kuriGanoderma lucidum) irashobora "kongera" urupfu rwa cisplatine kuri selile ya kanseri (ni ukuvuga, guteza imbere apoptose ya selile kanseri);Ibinyuranye na byo, byaba binyuranye n'ingirabuzimafatizo zisanzwe z'ibihaha cyangwa macrophage y'imbeba, WSG irashobora “kugabanya” kwangiza cisplatine ku ngirabuzimafatizo zisanzwe.

WSG yonyine ntacyo yangiza ku ngirabuzimafatizo za kanseri no mu ngirabuzimafatizo zisanzwe mu gihe cisplatine yonyine ishobora kwangiza kanseri ya kanseri ndetse na selile zisanzwe.Nyamara, imiyoborere ihuriweho na WSG na cisplatine irashobora kugabanya umuvuduko wokubaho kwingirangingo za kanseri kandi igaharanira umwanya munini wo kubaho kwingirabuzimafatizo zisanzwe, byerekana ko WSG ifite ingaruka zo kongera imbaraga za cisplatine no kugabanya uburozi bwa cisplatine.

Ubuzima bwimikorere ya selile adenocarcinoma selile, WSG na cisplatine bifatanije na 24h

Imikorere ya selile yingirabuzimafatizo zisanzwe zifite WSG cyangwa cisplatine kuri 24h

Imikorere ya selile yingirabuzimafatizo zisanzwe, WSG na cisplatine bifatanije na 24h

Ubushakashatsi bw’inyamaswa bwerekana ko imiyoborere ya WSG na cisplatine itinda gukura kwikibyimba.

Abashakashatsi bongeye gushyira imbeba y'ibihaha adenocarcinoma umurongo w'utugingo ngengabuzima tw’imbeba zigerageza.Mu rwego rwo kwirinda ko ubudahangarwa bw'umubiri bugira uruhare mu kurwanya kanseri, abashakashatsi babonye ingaruka WSG yinjira mu mubiri mu kuvura cisplatine.Nyuma yiminsi 21 yubushakashatsi, abashakashatsi basanze WSG yonyine cyangwa cisplatine yonyine ishobora gutuma ikibyimba gikura gahoro gahoro, kandi ingaruka zo guhagarika ikibyimba cya WSG ntizari munsi ya cisplatine, ariko ingaruka za WSG (Water Soluble) Polysaccharide ikomokaGanoderma lucidum) na cisplatine nibyiza.

Ingaruka zibuza WSG, cisplatine cyangwa byombi kumikurire ya adenocarcinoma y'ibihaha

Ubushakashatsi bw’inyamaswa bwerekana ko "WSG + cisplatine" igabanya indwara yibibyimba kandi igatera imbaraga.

Abashakashatsi bakoze kandi ubundi bushakashatsi bw’inyamaswa, batera umurongo wa selile adenocarcinoma umurongo uva mu murizo w’imbeba, hanyuma bakawuvura hamwe na WSG, cisplatine cyangwa byombi, maze bareba umubare w’ibibyimba cyangwa nodules byakuze mu bihaha no kubaho. y'imbeba nyuma yiminsi 21.Basanze WSG, cisplatine cyangwa ubuyobozi bukomatanyije byombi bishobora kubuza ikibyimba cyangwa nodules, kandi birashobora no kuramba ku mbeba z’ibihaha adenocarcinoma, ariko itsinda ryitwaye neza ni imbeba zitunguranye zitunguranye imbeba adenocarcinoma yimiti ivurwa na WSG yonyine.WSG (Amazi meza ya Polysaccharide akomokaGanoderma lucidum) bigaragara neza uruhare runini mugutezimbere imikorere yumubiri no kurinda selile zisanzwe.

Kubuza gukura kw'ibibyimba cyangwa nodules mu bihaha na WSG, cisplatine cyangwa byombi n'ingaruka zabyo mubuzima

WSG ninziza kimwe mubyaha no kwirwanaho mu kurwanya kanseri.

Ingaruka za WSG kubuza ibibyimba no kurinda ubuzima mubushakashatsi bwinyamanswa ntago ari munsi cyangwa nziza kuruta iya cisplatine yonyine cyangwa ifatanije na cisplatine, ibyo ahanini bikaba biterwa nuko WSG (Amazi ya Soluble Polysaccharide yakomotse kuriGanoderma lucidum) ishoboye guhagarika kanseri ya kanseri ikimara kugaragara.

Imbere ya selile ya kanseri itarakura igahinduka ibibyimba, mugihe cyose dushobora guhita dukora cyane kugirango tunoze imikorere yumubiri no kurinda selile zisanzwe, burigihe byoroshye kugabanya kwangirika kwingirangingo za kanseri.

Kubwibyo, ibisubizo byubushakashatsi byavuzwe haruguru ntibitanga gusa ishingiro ryokwongera imbaraga nuburozi kugabanya imiti ya chimiotherapie ahubwo binagaragaza ko gukoresha WSG mugihe cya chimiotherapie rwose ari inyongera aho kuba minus cyangwa kwivanga, kandi bikatwibutsa akamaro kandi birashoboka gufata ingamba zo gukumira mbere na mbere.

Gusa muri ubu bushakashatsi, WSG yahawe inyamaswa zigeragezwa hakoreshejwe inshinge za intraperitoneal.Imikorere yo kwinjiza peritoneyale mu mara yihuta kuruta iyo gufata umunwa, kandi ikinini cya intraperitoneal nacyo kiri munsi yikigereranyo gisabwa nubuyobozi bwo munwa.Niyo mpamvu, urugero rwa WSG rugomba gufatwa mu kanwa kugira ngo rugire ingaruka zimwe n’inshinge za intraperitoneal zikwiye gusuzumwa n’abashakashatsi.

[Inkomoko] Wei-Lun Qiu, n'abandi.WSG, Glucose-ikungahaye kuri Polysaccharide kuvaGanoderma lucidum, Hamwe na Cisplatin Potentiates Kubuza Kanseri yibihaha Muri Vitro no muri Vivo.Polimeri (Basel).2021; 13 (24): 4353.

IHEREZO

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Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.