dezembro 13, 2019 / Yeungnam University, etc.. / Relatórios científicos
Text / Wu Tingyao
Just as the daily lives of all human beings are upset by the 2019 novel coronavirus, there are still many viruses that are incurable. Dengue fever virus that infects humans through mosquito bites is one of them.
Like all viruses, the dengue virus that infects humans through mosquito bites also uses cells to reproduce the next generation. Portanto, how to interfere with the replication process of the virus in cells has become the main countermeasure for the development of related drugs.
Atualmente, many studies have targeted the dengue virus NS2B-NS3 protease, because it is an indispensable element for the dengue virus to complete the replication process. Without its role, the virus cannot reproduce itself to infect other cells.
According to a study published in “Scientific Reports” in December 2019, the Biotechnology Institute of Yeungnam University in South Korea and teams from India and Turkey screened 22 kinds of triterpenoids from the fruiting body ofGanoderma lucidum and found that four of them showed potential inhibition of NS2B-NS3 protease activity.
By the use of in vitro experiments to simulate the way the virus infects cells in the body, the researchers further evaluated two kinds ofGanoderma lucidum triterpenóides :
The researchers first cultured the dengue virus type 2 (DENV-2, the type most likely to cause severe illness) with human cells for 1 hour, and then treated them with different concentrations (25 ou 50 μM) deGanoderma lucidum triterpenoids for 1 hour. Depois 24 horas, they analyzed the ratio of cells infected by the virus.
The results showed that ganodermanontriol can reduce the cell infection rate by approximately 25% (25μM) ou 45% (50μM) while the relative ganoderic acid C2 does not have much inhibitory effect.
The results of this research provide us with another antiviral possibility ofGanoderma lucidum and also provide a new opportunity for the treatment of dengue fever, for which there is no specific drug available.
The above is a schematic diagram of the steps of screening candidate drugs to inhibit the dengue virus fromGanoderma lucidum triterpenoids with NS2B-NS3 protease as the target. The statistical chart at the bottom right shows the inhibitory rate of ganodermanontriol on cells infected with dengue fever virus type 2.
[Fonte] Bharadwaj S, et al. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Sci Rep. 2019 Dec 13;9(1):19059. doi: 10.1038/s41598-019-55723-5.
FIM
Sobre o autor/ ms. Wu Tingyao
Wu Tingyao está relatando informações sobre informações de Ganoderma Lucidum em primeira mão desde 1999. She is the author of Healing with Ganoderma (Publicado na editora médica do povo em abril 2017).
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★ O texto original deste artigo foi escrito em chinês por Wu Tingyao e traduzido para o inglês por Alfred Liu. Se houver alguma discrepância entre a tradução (Inglês) e o original (chinês), o chinês original prevalecerá. Se os leitores tiverem alguma dúvida, entre em contato com o autor original, EM. Wu Tingyao.
