Ngakhale kuti dziko lasintha kwambiri, chimene sichinasinthe n’chakuti khansa ya m’mapapo idakali vuto lalikulu kwa thanzi la munthu;ngakhale kubwerezedwa mobwerezabwereza kwa mankhwala oletsa khansa, mankhwala achikhalidwe cha chemotherapy akadali choipa chofunikira nthawi zambiri.

Komabe, ngati maselo abwinobwino sali otetezedwa bwino, mosasamala kanthu kuti mankhwala amphamvu amphamvu amphamvu bwanji, zimakhala zovuta kuti wodwalayo apirire.

Momwe mungadzitetezere panthawi ya chemotherapy?Tengani zotsatira za chemotherapy momwe mungathere ndikuchotsa kawopsedwe ka chemotherapy?Kuphatikiza ndiGanoderma lucidumma polysaccharides panthawi ya chemotherapy ndi njira yomwe iyenera kuganiziridwa mozama.

Kafukufuku wofalitsidwa mu Disembala 2021 ya "International Journal of Biological Macromolecules" ndi Pulofesa Wothandizira Tung-Yi Lin et al.kuchokera ku Institute of Traditional Medicine ya National Yang Ming Chiao Tung University ku Taiwan atsimikizira kudzera mu kuyesa kwa ma cell ndi nyama kutiWSG (Water Soluble Polysaccharide yochokera kuGanoderma lucidum)Sizingangowonjezera kulepheretsa kwa mankhwala a chemotherapy cisplatin pa lung adenocarcinoma komanso kuteteza maselo a chitetezo chamthupi ndi maselo abwinobwino ndikuwonjezera kwambiri kupulumuka kwa nyama zoyesera. 

Kuyesa kwa ma cell kunawonetsa kuti kuphatikiza kwa WSG ndi cisplatin kumawonjezera mphamvu ya cisplatin ndikuchepetsa kawopsedwe ka cisplatin.

Ofufuzawa adaphatikiza kayendetsedwe ka WSG ndi cisplatin kuti awone zomwe zimachitika pama cell amapapu adenocarcinoma ndi ma cell abwinobwino mu vitro.

Zinapezeka kuti ngakhale zinali zotsutsana ndi maselo a mapapu adenocarcinoma aumunthu kapena maselo a mbewa adenocarcinoma, WSG (Water Soluble Polysaccharide yochokera kuGanoderma lucidum) ikhoza "kuwonjezera" kupha kwa cisplatin pama cell a khansa (ndiko kuti, kulimbikitsa apoptosis ya maselo a khansa);M'malo mwake, ngakhale zinali zotsutsana ndi maselo am'mapapo wamba kapena macrophages a mbewa, WSG imatha "kuchepetsa" kuwonongeka kwa cisplatin ku maselo abwinobwino.

WSG yokha ilibe vuto lililonse ku maselo a khansa ndi maselo abwinobwino pomwe cisplatin yokha imatha kuwononga ma cell a khansa komanso maselo abwinobwino.Komabe, kuphatikiza kwa WSG ndi cisplatin kumatha kuchepetsa kupulumuka kwa ma cell a khansa ndikuyesetsa kukhala ndi malo ochulukirapo a maselo abwinobwino, kuwonetsa kuti WSG ili ndi zotsatira zokulitsa mphamvu ya cisplatin ndikuchepetsa kawopsedwe ka cisplatin.

Kutheka kwa ma cell a lung adenocarcinoma cell, WSG ndi cisplatin opangidwa kwa 24h.

Kutheka kwa ma cell a ma cell abwinobwino opangidwa ndi WSG kapena cisplatin kwa 24h

Kutheka kwa ma cell a ma cell abwinobwino, WSG ndi cisplatin omwe amapangidwa kwa 24h

Zoyeserera zanyama zikuwonetsa kuti kuphatikiza kwa WSG ndi cisplatin kumachepetsa kukula kwa chotupa.

Ofufuzawo adayikanso mzere wa cell wa mbewa adenocarcinoma mu minofu ya subcutaneous ya mbewa zoyesera.Pokhala kuti chitetezo chamthupi chimagwiranso ntchito polimbana ndi khansa, ofufuzawo adawona momwe WSG imalowa m'thupi pochiza cisplatin.Pambuyo pakuyesera kwa masiku 21, ofufuzawo adapeza kuti WSG yokha kapena cisplatin yokha imatha kupangitsa chotupacho kuti chikule pang'onopang'ono komanso chocheperako, ndipo chotupa choletsa chotupa cha WSG sichinali chocheperako kuposa cisplatin, koma kuphatikiza kwa WSG (Water Soluble). Polysaccharide yochokera kuGanoderma lucidum) ndipo cisplatin ndiye wabwino kwambiri.

Kuletsa kwa WSG, cisplatin kapena onse pakukula kwa lung adenocarcinoma

Zoyeserera zanyama zikuwonetsa kuti "WSG + cisplatin" imachepetsa kuchuluka kwa chotupa ndikuwongolera magwiridwe antchito.

Ofufuzawo adachitanso kuyesa kwina kwa nyama, kubaya chingwe cha cell yamapapu adenocarcinoma kuchokera ku mchira wa mbewa, kenako ndikuchiza ndi WSG, cisplatin kapena zonse ziwiri, ndikuwona kuchuluka kwa zotupa kapena tinthu tating'onoting'ono tomwe tidakula m'mapapo ndi kupulumuka. za mbewa patatha masiku 21.Iwo adapeza kuti WSG, cisplatin kapena ophatikizana makonzedwe a onse akhoza ziletsa mapangidwe zotupa kapena tinatake tozungulira, komanso akhoza kutalikitsa moyo wa mapapu adenocarcinoma mbewa, koma gulu ndi ntchito bwino anali mosayembekezereka mapapu adenocarcinoma mbewa mankhwala ndi WSG yekha.WSG (Water Soluble Polysaccharide yochokera kuGanoderma lucidum) momveka bwino kumathandiza kwambiri kuti chitetezo cha mthupi chitetezeke komanso kuteteza maselo abwinobwino.

Kuletsa kukula kwa zotupa kapena tinatake m'mapapo ndi WSG, cisplatin kapena zonse ziwiri komanso momwe zimakhudzira moyo wawo.

WSG ndiyabwinonso pakulakwira komanso chitetezo polimbana ndi khansa.

Zotsatira za WSG pakuletsa chotupa komanso kuteteza moyo pakuyesa nyama ndizochepera kapena zabwinoko kuposa za cisplatin yokha kapena kuphatikiza ndi cisplatin, zomwe zimachitika makamaka chifukwa chakuti WSG (Water Soluble Polysaccharide yochokera ku).Ganoderma lucidum) amatha kupondereza maselo a khansa atangowonekera.

Poyang'anizana ndi maselo a khansa omwe sanakule ndi kupanga zotupa, malinga ngati titha kugwira ntchito mwakhama kuti titeteze chitetezo cha mthupi komanso kuteteza maselo abwino, nthawi zonse zimakhala zosavuta kuchepetsa kuwonongeka kwa maselo a khansa.

Chifukwa chake, zotsatira zafukufuku zomwe zili pamwambapa sizimangopereka maziko owonjezera komanso kuchepetsa kawopsedwe kwa mankhwala a chemotherapy komanso zimatsimikizira kuti kugwiritsa ntchito WSG panthawi ya chemotherapy ndikowonjezera osati kungochepetsa kapena kusokoneza, komanso kumatikumbutsa kufunikira ndi kusokoneza. kuthekera kochita zodzitetezera poyambirira.

Pokhapokha mu phunziro ili, WSG inaperekedwa kwa nyama zoyesera ndi jekeseni wa intraperitoneal.Kuchita bwino kwa mayamwidwe a peritoneal mumatumbo am'mimba kumathamanga kwambiri kuposa momwe amamwa m'kamwa, ndipo intraperitoneal mlingo ndi wocheperako poyerekeza ndi mlingo womwe umafunikira pakamwa.Chifukwa chake, kuchuluka kwa mlingo wa WSG wofunika kutengedwa pakamwa kuti mupeze zotsatira zofananira ndi jakisoni wa intraperitoneal ndioyenera kuganiziridwanso ndi ofufuza.

[Source] Wei-Lun Qiu, et al.WSG, Glucose-Rich Polysaccharide yochokeraGanoderma lucidum, Kuphatikiza ndi Cisplatin Potentiates Inhibition of Lung Cancer In Vitro ndi In Vivo.Ma polima (Basel).2021;13(24):4353 .

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