Avril 12, 2017 / University of Brawijaya / Heart International
Texte/ Wu Tingyao
Long-term high-cholesterol diet can easily lead to abnormal blood lipids, and long-term abnormal blood lipids can lead to atherosclerosis. Cependant, siGanoderma lucidum polysaccharides is intervened, even if blood lipids are still abnormal, the risk of atherosclerosis is likely to be reduced.
“Heart International” published a report from the University of Brawijaya in Indonesia in 2017, proving thatGanoderma lucidum peptides polysaccharidiques (protein-rich β-D-glucan extracted fromGanoderma lucidum) have this protective effect.
Multiple effects against atherosclerosis
The researchers fed the rats with a high-cholesterol diet for 12 semaines. Three groups of rats were simultaneously fed with low, doses moyennes et élevées (50, 150, 300 mg/kg) deGanoderma lucidum peptides polysaccharidiques (PsP) préparation, which contains 20%Ganoderma lucidum peptides polysaccharidiques, in the last 4 weeks of the experiment.
After the experiment, the health of the rats’ blood vessels was analyzed through four indicators, and the following results were found regarding the rats that ateGanoderma lucidum peptides polysaccharidiques:
1. The concentration of free radicals H2O2 in the serum is significantly lower — the low-density lipoprotein cholesterol (LDL-C) accumulated in the blood vessel wall is oxidized by free radicals, which is the first step in the formation of atherosclerosis. When free radicals decrease, the chance of atherosclerosis naturally decreases.
2. The secretion of IL-10, an anti-inflammatory cytokine, is reduced — it means that the degree of inflammation is mild, so there is no need for so much IL-10 to fight inflammation.
3. Le nombre de « cellules progénitrices endothéliales » qui peuvent être utilisées pour réparer les parois des vaisseaux sanguins endommagées a augmenté : les cellules progénitrices endothéliales qui circulent dans tout le corps avec le sang peuvent réparer les parois des vaisseaux sanguins endommagées par l'oxydation et l'inflammation.. Donc, l'augmentation du nombre de cellules progénitrices endothéliales indique que la possibilité de réparer la paroi endommagée des vaisseaux sanguins est augmentée, et le risque d'évolution vers l'athérosclérose est relativement réduit.
4. L'épaisseur de la paroi interne de l'aorte (Intimité et médias) est proche de la normale — la section transversale du vaisseau artériel peut être divisée en trois couches de l'intérieur vers l'extérieur: la paroi du vaisseau sanguin en contact avec le flux sanguin s'appelle l'intima, which is composed of endothelial cells; the middle layer composed of smooth muscle is called the media. These two layers of vascular tissues are the most important lesion areas of atherosclerosis. Donc, when the thickness of the two layers is closer to normal, it means that the arteries are in a relatively healthy state.
Free radical concentration in rat serum
[Note] H2O2 is a kind of free radical. The lower its concentration, the less likely it is to form atherosclerosis. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)
The concentration of anti-inflammatory cytokine in rat serum
[Note] When the anti-inflammatory IL-10 concentration in the serum is not so high, it implies that the inflammation of the blood vessel wall may not be so severe, and the risk of atherosclerosis is also reduced. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)
The number of endothelial progenitor cells in rat blood
[Note] Endothelial progenitor cells can repair damaged blood vessel walls. When their number increases, it means that the risk of atherosclerosis is reduced or can be delayed. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)
The thickness of the arterial wall of the rat
[Note] The vascular “intima” and “media” are the most important lesion areas of atherosclerosis. The closer their thickness is to that of arteries under normal diet, the healthier the blood vessels will be.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)
La protection deGanoderma lucidum polysaccharide peptides on the cardiovascular system may not be fully reflected in the visible indicators.
The above experiments show that although the cause of atherosclerosis (régime riche en graisses) still exists, and blood lipids are still abnormal, Ganoderma lucidum polysaccharide peptides can keep the artery blood vessels in a relatively healthy state through the triple effects of anti-oxidation, anti-inflammation and improving the chance of repairing damaged blood vessel walls. And the effect ofGanoderma lucidum polysaccharide peptides is proportional to its dosage.
Because the research team has previously confirmed through clinical studies that the use of thisGanoderma lucidum polysaccharide peptides preparation for adjuvant treatment of patients with angina pectoris can greatly improve inflammation, oxidative damage, blood sugar, and blood lipids in the body, thereby reducing the frequency and severity of angina pectoris. Donc, the clinical application potential ofGanoderma lucidum polysaccharide peptides is indeed worthy of our expectations.
Many studies in the past have used “lowering blood lipids to normal” as a specific indicator of the effectiveness ofGanoderma lucidum in protecting the cardiovascular system. Cependant, research from Indonesia tells us that even if blood lipids have not returned to normal, or even if angina pectoris still occurs, we should not get disappointed withGanoderma lucidum because it has been working, but you may not be able to see its effect with your own eyes. As long as it is eaten often and for a long time, la protection deGanoderma lucidum on the cardiovascular system will continue.
[Source de données] Wihastuti TA, et autres. The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia. Heart Int. 2017; 12(1): e1-e7.
FIN
À propos de l'auteur/Mme. Wu Tingyao
Wu Tingyao rapporte des informations de première main sur le Ganoderma depuis 1999. Elle est l'auteur de Guérir avec Ganoderma (publié dans The People's Medical Publishing House en avril 2017).
★ Cet article est publié sous l'autorisation exclusive de l'auteur.
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★ Le texte original de cet article a été rédigé en chinois par Wu Tingyao et traduit en anglais par Alfred Liu.. S'il y a une divergence entre la traduction (Anglais) et l'original (Chinois), le chinois original prévaudra. Si les lecteurs ont des questions, veuillez contacter l'auteur original, MS. Wu Tingyao.
