September 2018 / Fujian Medical University Union Hospital, etc.. / Integrative Cancer Therapies
Texte/ Wu Tingyao
Does eatingGanoderma lucidum help to relieve symptoms of brain tumor patients? This is probably the first report in an international journal to explore the effects ofGanoderma lucidum in inhibiting brain tumors in vivo through animal experiments– it can bring us some thoughts.
Glioma is a common type of brain tumor. It is caused by abnormal proliferation of glial cells that wrap around nerve cells. It may be a slow-growing benign tumor (whether it will cause headaches and other uncomfortable symptoms depends on the location and size of the tumor), or it may be a fast-growing malignant tumor.
Malignant glioma has lost the function of nourishing, supporting and protecting nerve cells. Not only does it grow fast, but it may also spread in a short time. This type of malignant glioma, which grows and spreads quickly, is also called glioblastoma. It is one of the most common and deadly brain tumors in humans. Even if patients receive aggressive treatment immediately after diagnosis, their average remaining life span is only 14 mois. Only 5% of patients survive for more than five years.
Donc, how to effectively strengthen the anti-cancer ability of the patient’s own immune system has become the main field of exploration in the treatment of glioblastoma in the medical field in recent years. It is an accepted fact thatGanoderma lucidum polysaccharides (GL-PS) can regulate immunity, but because the blood-brain barrier between the brain and blood vessels can selectively prevent certain substances in the blood from entering the brain cells, whetherGanoderma lucidum polysaccharides can inhibit glioblastoma in the brain needs to be further confirmed.
A report jointly published by Fujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University in September 2018 in “Integrative Cancer Therapies” confirmed that the polysaccharides isolated from the fruiting body ofGanoderma lucidum (GL-PS) can inhibit the growth of glioblastoma and prolong the survival period of tumor-bearing rats. Its mechanism of action is closely related to the improvement of immunity.
Experimental result 1: the tumor is relatively small
The GL-PS used in the experiment is a macromolecular polysaccharide with a molecular weight of nearly 585,000 and a protein content of 6.49%. The researchers first inoculated glioma cells into the rat brain, and then administered the GL-PS to the rat by intraperitoneal injection at a daily dose of 50, 100 ou 200 mg/kg).
After two weeks of treatment, the brain tumor size of the experimental rats was examined by MRI (Figure 1A). The results showed that compared with the control group rats that were inoculated with cancer cells but not given GL-PS, the tumor size of rats that were given 50 et 100 mg/kg GL-PS was reduced by about one-third on average (Figure 1B).
Chiffre 1 The inhibitory effect of GL-PS on brain tumors (gliomas)
Experimental result 2: prolonging survival
After the MRI was done, all experimental rats continued to be fed until they died. The results found that the longest alive were the rats given 100 mg/kg GL-PS. The average survival time was 32 jours, which was one-third longer than the 24 days of the control group. One of the rats was even alive for 45 jours. As for the other two groups of GL-PS rats, the average survival time is about 27 jours, which is not much different from that of the control group.
Chiffre 2 The effect of GL-PS on the life span of rats with brain tumors (gliomas)
Experimental result 3: Improving the anti-tumor ability of the immune system
The researchers further explored the effects ofGanoderma lucidum polysaccharides on the immune function of rats with brain tumors and found that the cytotoxic T cells (Chiffre 3) in the brain tumors and lymphocytes (including T Cells and B cells) in the spleen of the rats injected withGanoderma lucidum polysaccharides were significantly increased in the blood. The concentration of anti-tumor cytokines, such as IL-2 (interleukin-2), TNF-α (tumour necrosis factor α) and INF-γ (interferon gamma), secreted by immune cells was also higher than that of the control group.
En outre, the researchers have also confirmed through in vitro experiments thatGanoderma lucidum polysaccharides can not only enhance the lethality of natural killer cells against glioma cells but also promote dendritic cells (the cells responsible for identifying foreign enemies and initiating the immune response in the immune system) to speed up the activation of the immune system to combat cancer cells, and also contribute to the generation of cytotoxic T cells (which can kill cancer cells one-to-one).
Chiffre 3 The effect of GL-PS on the number of cytotoxic T-cells in brain tumors (gliomas)
[Description] This is a tissue section of a rat brain tumor, dans lequel la partie brune est constituée de lymphocytes T cytotoxiques. Le contrôle fait référence au groupe témoin, et les trois autres groupes sont des groupes GL-PS. Les données indiquées sont la dose deGanoderma lucidum polysaccharides injectés dans la cavité intrapéritonéale de rats porteurs de tumeurs.
Voyant l'opportunité deGanoderma lucidum des polysaccharides pour lutter contre les tumeurs cérébrales
Les résultats de recherche ci-dessus indiquent que la quantité appropriée deGanoderma lucidum les polysaccharides peuvent aider à combattre les tumeurs cérébrales. Parce que les polysaccharides injectés dans la cavité abdominale sont absorbés par la veine porte du foie et métabolisés par le foie, puis entrent dans la circulation sanguine pour interagir avec les cellules immunitaires du sang.. Donc, la raison pour laquelle la croissance des tumeurs cérébrales du rat peut être contrôlée et même la période de survie peut être prolongée devrait être liée à la stimulation de la réponse immunitaire et à l'amélioration de la fonction immunitaire parGanoderma lucidum polysaccharides.
Évidemment, la barrière hémato-encéphalique dans la structure physiologique ne protégera pas l'effet inhibiteur deGanoderma lucidumpolysaccharides sur les tumeurs cérébrales. Les résultats expérimentaux nous indiquent également que le dosage deGanoderma lucidum les polysaccharides ne sont pas plus, mieux c'est, mais trop peu semble avoir peu d'effet. Quel est le « montant approprié ». Il est possible que différentsGanoderma lucidum les polysaccharides ont leurs propres définitions, et la question de savoir si l'effet de l'administration orale peut être équivalent à celui de l'injection intrapéritonéale doit être confirmée par des recherches plus approfondies..
Cependant, these results have at least revealed the possibility of polysaccharides fromGanodermie lucide inhibiting brain tumor growth and prolonging survival, which may be worth a try in the current situation of limited treatment.
[Source] Wang C, et autres. Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats. Integr Cancer Ther. 2018 Sep;17(3):674-683.
[Références] Tony D’Ambrosio. Glioma vs. Glioblastoma: Understanding Treatment Differences. Neurosurgeons of New Jersey. 2017 Août 4.
FIN
À propos de l'auteur/Mme. Wu Tingyao
Wu Tingyao rapporte des informations de première main sur le Ganoderma depuis 1999. Elle est l'auteur deGuérir avec Ganoderma (publié dans The People's Medical Publishing House en avril 2017).
★ Cet article est publié sous l'autorisation exclusive de l'auteur.
★ Les œuvres ci-dessus ne peuvent pas être reproduites, extrait ou utilisé d’une autre manière sans l’autorisation de l’auteur.
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★ Le texte original de cet article a été rédigé en chinois par Wu Tingyao et traduit en anglais par Alfred Liu.. S'il y a une divergence entre la traduction (Anglais) et l'original (Chinois), le chinois original prévaudra. Si les lecteurs ont des questions, veuillez contacter l'auteur original, MS. Wu Tingyao.
