في أبريل 2024, a research team jointly led by Professor Jia Li and Associate Professor Xie Xiaodong from the Biomedical Research Center of the College of Materials and Chemical Engineering, جامعة مينجيانغ, in collaboration with the College of Chemistry, جامعة فوتشو, the School of Pharmacy, جامعة فوجيان للطب الصيني التقليدي, the Translational Research Centre in Onco-Hematology (CRTOH), Faculty of Medicine, University of Geneva, Switzerland, and Fujian Xianzhilou Biological Science and Technology Co., المحدودة. (فوتشو), published a study in the Journal of the Chinese Medical Association.
The study demonstrated that غانوديرما لوكيدوم زيت البوغ (GLSO) can enhance the effect of the chemotherapeutic drug cyclophosphamide (CTX) in inhibiting breast cancer lung metastasis in animals, with the mechanism linked to an enhancement of anti-tumor immunity.
غانوديرما لوسيدوم Spore Oil: Rich in Active Ingredients
The غانوديرما لوكيدوم زيت البوغ (GanoOil) used in this study was extracted by Fujian Xianzhilou Biological Science and Technology Co., المحدودة. (فوتشو) from a specific source of غانوديرما لوكيدوم spore powder using supercritical CO2 اِستِخلاص. Analysis by the research team confirmed that this spore oil is rich in ergosterol (تقريبًا 230 mg per 100 g of spore oil), Reishi total triterpenoids (تقريبًا 34-35 g per 100 g of spore oil), and various unsaturated fatty acids (كما هو مبين في الشكل أدناه).
زيت بوغ جانوديرما لوسيدوم: High Safety and Immune-Boosting Properties
The research team also evaluated the safety of غانوديرما لوكيدوم spore oil through in vitro and in vivo experiments. They cultured different concentrations of spore oil with various cancer cells or normal cells for 24 hours to observe cell viability. Additionally, healthy mice without tumors were orally administered 0.5 g/kg of غانوديرما لوكيدوم spore oil daily for 28 days. The results showed:
➤ The viability of both cancer cells and normal cells is unaffected by غانوديرما لوكيدوم زيت البوغ (indicating no toxic damage).
➤ No significant changes in body weight were observed in the mice during the experiment.
➤ At the end of the experiment, important organs like the heart, الكبد, الطحال, الرئتين, and kidneys of the mice were all normal (no toxic reactions or pathological changes occurred).
Histopathological analysis showed no significant differences in organ tissues between the two groups, indicating that long-term daily administration of high doses (0.5g/kg) of غانوديرما لوكيدوم spore oil had no apparent toxicity or side effects in mice.
➤ The activity of natural killer (نك) cells and the overall number of lymphocytes (including T cells, B cells, and NK cells) in the mice’s spleens significantly increased.
➤ There was also a tendency for an increase in CD8+ T cells (الخلايا التائية السامة للخلايا), which can directly kill cancer cells or pathogens, in the mice’s blood circulation. Although the increase did not reach statistical significance, it still suggests a positive impact of غانوديرما لوكيدوم spore oil on immunity.
These results indicate that daily oral administration of high-dose غانوديرما لوكيدوم spore oil is not only safe for consumption but also beneficial for enhancing immunity.
غانوديرما لوسيدوم Spore Oil يستطيع Assist جhemotherapeutic دrugs in Reducing Lung Metastasis
The researchers further investigated the in vivo anti-cancer effect of غانوديرما لوكيدوم spore oil using an experimental model of breast cancer lung metastasis. During the 21-day experimental period, mice were orally administered 0.3 g/kg of غانوديرما لوكيدوم spore oil daily. Three days after starting spore oil administration, metastatic triple-negative breast cancer 4T1 cells were intravenously injected into the mice. The chemotherapeutic drug CTX (cyclophosphamide) was administered via intraperitoneal injection at a dose of 0.05 g/kg, for a total of 3 injections. The results showed:
➤ Tumor-bearing mice receiving both غانوديرما لوكيدوم spore oil and CTX chemotherapy had significantly fewer tumors in their lungs compared to groups receiving no treatment, غانوديرما لوكيدوم spore oil alone, or chemotherapy alone. This indicates that the combined use of غانوديرما لوكيدوم spore oil and CTX has a better inhibitory effect on breast cancer cell metastasis from the bloodstream to the lungs.
➤ In tumor-bearing mice treated concurrently with غانوديرما لوكيدوم spore oil and the chemotherapeutic agent CTX, not only was their body weight not significantly different from that of normal mice, but the ratios of lung weight and spleen weight to body weight were also very similar to those of normal mice. This indicates that the combined use of غانوديرما لوكيدوم spore oil and CTX can prevent weight loss and abnormal enlargement of the lungs and spleen typically caused by cancer itself and by chemotherapeutic drugs.
➤ While combined use of غانوديرما لوكيدوم spore oil and chemotherapy did not increase the proportion of CD4+ T cells among lymphocytes, it did increase the proportion of CD8+ T cells (cytotoxic T cells that can directly kill cancer cells) in the blood, enhanced the activity of natural killer cells in the spleen, and promoted the content of the cytokine IL-6 in the blood. لذلك, the ability of غانوديرما لوكيدوم spore oil to assist chemotherapeutic agents in preventing breast cancer cell metastasis to the lungs is likely achieved through the enhancement of anti-tumor immunity.
غانوديرما لوسيدوم Spore Oil: Both a Health Food and a Chemotherapy Adjuvant
Based on the above research findings, it can be concluded that daily supplementation with غانوديرما لوكيدوم spore oil can enhance immunity before tumor onset. When tumors are present, daily supplementation with غانوديرما لوكيدوم spore oil can also improve the inhibitory ability of chemotherapeutic drugs on cancer metastasis.
لذلك, غانوديرما لوكيدوم spore oil is not only a daily health food but also a beneficial chemotherapy adjuvant. والأهم من ذلك, its high dietary safety means it does not cause harm or burden to the heart, الكبد, الطحال, الرئتين, or kidneys.
Everyone has cancer cells, but not everyone develops cancer; even if cancer occurs, metastasis doesn’t always happen. The key lies in anti-tumor immunity. Immunity can be weakened by factors such as age, ضغط, pollution, مرض, and medication. لذلك, it’s crucial to maintain immunity daily, even when healthy. Long-term maintenance of good immunity is a self-protective measure against cancer and for fighting it.
مرجع:
Shu Lian, وآخرون.غانوديرما لوكيدوم spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis. J Chin Med Assoc. 2024 Mar 1;87(3):305-313.
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★ The original manuscript of this article was authored in Chinese by Wu Tingyao and subsequently translated into English by Alfred Liu. في حالة حدوث أي تناقضات بين الترجمة الإنجليزية والنص الصيني الأصلي, يجب أن يأخذ الأخير الأسبقية. لأي استفسارات, الرجاء التواصل مع المؤلف الأصلي, آنسة. وو تينغياو.
